Nomenclature and diagnosis of amyloidosis from a historical perspective

Mostrar todas las versiones(2)

Introduction: Amyloidosis is a rare chronic disease, characterized by extracellular deposition of fibrillar proteins in various organs and tissues. The clinical manifestations are based on the site of the deposits and the precursor protein involved. The main diagnostic tool is clinical suspicion. Th...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Aguirre, María Adela, Carretero, Marcelina, Nucifora, Elsa, Posadas, María Lourdes
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021
Materias:
amiloidose
historia
amilóide
amyloidosis
hystory
amyloid
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/25202
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10-article-25202
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
topic amiloidose
historia
amilóide
amiloidose
historia
amilóide
amyloidosis
hystory
amyloid
spellingShingle amiloidose
historia
amilóide
amiloidose
historia
amilóide
amyloidosis
hystory
amyloid
Aguirre, María Adela
Carretero, Marcelina
Nucifora, Elsa
Posadas, María Lourdes
Nomenclature and diagnosis of amyloidosis from a historical perspective
topic_facet amiloidose
historia
amilóide
amiloidose
historia
amilóide
amyloidosis
hystory
amyloid
author Aguirre, María Adela
Carretero, Marcelina
Nucifora, Elsa
Posadas, María Lourdes
author_facet Aguirre, María Adela
Carretero, Marcelina
Nucifora, Elsa
Posadas, María Lourdes
author_sort Aguirre, María Adela
title Nomenclature and diagnosis of amyloidosis from a historical perspective
title_short Nomenclature and diagnosis of amyloidosis from a historical perspective
title_full Nomenclature and diagnosis of amyloidosis from a historical perspective
title_fullStr Nomenclature and diagnosis of amyloidosis from a historical perspective
title_full_unstemmed Nomenclature and diagnosis of amyloidosis from a historical perspective
title_sort nomenclature and diagnosis of amyloidosis from a historical perspective
description Introduction: Amyloidosis is a rare chronic disease, characterized by extracellular deposition of fibrillar proteins in various organs and tissues. The clinical manifestations are based on the site of the deposits and the precursor protein involved. The main diagnostic tool is clinical suspicion. The prognosis is usually bleak. The objective of this study is to describe the events that happened over time to reach what we know today as amyloidosis.Materials and methods: an exploratory, narrative, historical study was carried out. Primary sources and affected documentary sources were reviewed. Development: The first descriptions of patients with amyloidosis date from the mid 1600 AD. These were anatomical descriptions, reported from autopsies of patients. The first approximations to the diagnosis were through stains with iodine and anilines, finally reaching X-ray diffraction, and microscopy with polarized light under staining with Congo red. Conclusions: Despite being a nosological entity known for four centuries, the difficulties to characterize the origin and understand the pathophysiology of amyloidosis still remain. For decades there were controversies about the nomenclature and the nature of amyloid material. The diagnosis and management of this disease follow the control of advances in technology, currently being a challenge in the management of patients suffering from amyloidosis.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2021
url https://revistas.unc.edu.ar/index.php/med/article/view/25202
work_keys_str_mv AT aguirremariaadela nomenclatureanddiagnosisofamyloidosisfromahistoricalperspective
AT carreteromarcelina nomenclatureanddiagnosisofamyloidosisfromahistoricalperspective
AT nuciforaelsa nomenclatureanddiagnosisofamyloidosisfromahistoricalperspective
AT posadasmarialourdes nomenclatureanddiagnosisofamyloidosisfromahistoricalperspective
AT aguirremariaadela nomenclaturaydiagnosticodelaamiloidosisdesdeunaperspectivahistorica
AT carreteromarcelina nomenclaturaydiagnosticodelaamiloidosisdesdeunaperspectivahistorica
AT nuciforaelsa nomenclaturaydiagnosticodelaamiloidosisdesdeunaperspectivahistorica
AT posadasmarialourdes nomenclaturaydiagnosticodelaamiloidosisdesdeunaperspectivahistorica
AT aguirremariaadela nomenclaturaediagnosticodeamiloidosedeumaperspectivahistorica
AT carreteromarcelina nomenclaturaediagnosticodeamiloidosedeumaperspectivahistorica
AT nuciforaelsa nomenclaturaediagnosticodeamiloidosedeumaperspectivahistorica
AT posadasmarialourdes nomenclaturaediagnosticodeamiloidosedeumaperspectivahistorica
first_indexed 2022-08-20T01:26:28Z
last_indexed 2022-08-20T01:26:28Z
_version_ 1770718996763508736
spelling I10-R10-article-252022021-07-07T13:29:31Z Nomenclature and diagnosis of amyloidosis from a historical perspective Nomenclatura y diagnóstico de la amiloidosis desde una perspectiva histórica Nomenclatura e diagnóstico de amiloidose de uma perspectiva histórica Aguirre, María Adela Carretero, Marcelina Nucifora, Elsa Posadas, María Lourdes amiloidose historia amilóide amiloidose historia amilóide amyloidosis hystory amyloid Introduction: Amyloidosis is a rare chronic disease, characterized by extracellular deposition of fibrillar proteins in various organs and tissues. The clinical manifestations are based on the site of the deposits and the precursor protein involved. The main diagnostic tool is clinical suspicion. The prognosis is usually bleak. The objective of this study is to describe the events that happened over time to reach what we know today as amyloidosis.Materials and methods: an exploratory, narrative, historical study was carried out. Primary sources and affected documentary sources were reviewed. Development: The first descriptions of patients with amyloidosis date from the mid 1600 AD. These were anatomical descriptions, reported from autopsies of patients. The first approximations to the diagnosis were through stains with iodine and anilines, finally reaching X-ray diffraction, and microscopy with polarized light under staining with Congo red. Conclusions: Despite being a nosological entity known for four centuries, the difficulties to characterize the origin and understand the pathophysiology of amyloidosis still remain. For decades there were controversies about the nomenclature and the nature of amyloid material. The diagnosis and management of this disease follow the control of advances in technology, currently being a challenge in the management of patients suffering from amyloidosis. Introducción: La amiloidosis es una enfermedad crónica infrecuente, que se caracteriza por el depósito extracelular de proteínas fibrilares en diversos órganos y tejidos. Las manifestaciones clínicas se basan según el sitio de los depósitos y de la proteína precursora involucrada. La principal herramienta de diagnóstico es la sospecha clínica.  El pronóstico suele ser sombrío. El objetivo de este estudio es describir los acontecimientos que fueron sucediendo en el tiempo para llegar a lo que conocemos en la actualidad como amiloidosis. Materiales y métodos: se realizó un estudio exploratorio, narrativo, de carácter histórico. Se revisaron fuentes primarias y fuentes documentales existentes. Desarrollo: Las primeras descripciones de pacientes con amiloidosis datan de mediados de 1600 d.c. Éstas eran descripciones anatómicas, reportadas a partir de autopsias de pacientes. Las primeras aproximaciones al diagnóstico  fueron a través de tinciones con iodo y anilinas, llegando por último a la difracción por rayos x, y la microscopía con luz polarizada bajo tinción con rojo Congo. Conclusiones: A pesar de ser una entidad nosológica conocida desde hace cuatro siglos, las dificultades para caracterizar el origen y comprender la fisiopatología de la amiloidosis aún permanecen. Durante décadas hubo controversias acerca de la nomenclatura y la naturaleza del material amiloideo. El diagnóstico y el manejo de esta enfermedad siguen dependiendo de los avances en la tecnología, siendo actualmente un desafío en el manejo de los pacientes que padecen amiloidosis. Introdução: A amiloidose é uma doença crônica rara, caracterizada pela deposição extracelular de proteínas fibrilares em vários órgãos e tecidos. As manifestações clínicas são baseadas no local dos depósitos e da proteína precursora envolvida. A principal ferramenta diagnóstica é a suspeita clínica. O prognóstico geralmente é sombrio [1]. O objetivo deste estudo é descrever os eventos que ocorreram ao longo do tempo para alcançar o que hoje conhecemos como amiloidose.Materiais e métodos: foi realizado um estudo exploratório, narrativo, histórico. Fontes primárias e fontes documentais afetadas foram revisadas.Desenvolvimento: As primeiras descrições de pacientes com amiloidose datam de meados de 1600 AD. Essas foram descrições anatômicas, relatadas em autópsias de pacientes. As primeiras aproximações para o diagnóstico foram através de colorações com iodo e anilinas, atingindo finalmente a difração de raios X, e microscopia com luz polarizada sob coloração com vermelho do Congo.Conclusões: Apesar de ser uma entidade nosológica conhecida há quatro séculos, ainda persistem as dificuldades em caracterizar a origem e compreender a fisiopatologia da amiloidose. Durante décadas houve controvérsias sobre a nomenclatura e a natureza do material amilóide. O diagnóstico e o manejo dessa doença seguem o controle dos avanços tecnológicos, sendo atualmente um desafio no manejo dos pacientes portadores de amiloidose. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-03-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion estudio exploratorio, narrativo, de carácter histórico Estudio exploratorio, narrativo, de carácter histórico estudio exploratorio, narrativo, de carácter histórico application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/25202 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. 1 (2021); 83-87 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. 1 (2021); 83-87 Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. 1 (2021); 83-87 1853-0605 0014-6722 10.31053/1853.0605.v78.n1 spa https://revistas.unc.edu.ar/index.php/med/article/view/25202/33319 https://revistas.unc.edu.ar/index.php/med/article/view/25202/32982 Derechos de autor 2021 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0

Ejemplares similares