Loxosceles cutaneous-visceral hemolytic renal failure acute
The Loxoscelism is caused by the bite of spider Loxosceles laeta gender, of worldwide distribution. The poisoning can cause lesions dermonecrotic and less frequently a systemic illness that can be fatal.The mechanism of venom action is multifactorial. The characteristic dermonecrotic lesion results...
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2019
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/23570 |
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I10-R10-article-235702019-05-20T10:45:36Z Loxosceles cutaneous-visceral hemolytic renal failure acute Loxoscelismo cutáneo-viscero-hemolítico con fallo renal agudo Alfaro, Flavia V. Dotto, Beatriz H. Sesin, Ana M. Prettini, Viviana Sesin, Jorge Aliciardi, Enrique Vergottini, Juan C. Gonzalez, Mauricio insuficiencia renal veneno picadura de araña lesiones dermonecróticas hemólisis loxosceles laeta dermonecrotic lesions cutáneo-visceral lesions acute renal injury The Loxoscelism is caused by the bite of spider Loxosceles laeta gender, of worldwide distribution. The poisoning can cause lesions dermonecrotic and less frequently a systemic illness that can be fatal.The mechanism of venom action is multifactorial. The characteristic dermonecrotic lesion results from the direct effects of the venom on the celular and basal membrane components , as well as the extracelular matrix.The initial interaction between the poison and tissues, causes complement activation , migration of polymorphic neutrophils, liberation of proteolytic enzymes, cytoquines, aggregation platelet, and blood flow alterations that result in edema and ischemia, with development of necrosis. There is no a definitive treatment for loxoscelism. However, the value of specific antivenom, to decrease lesion size and limit systemic illness even when such administration is delayed. We present a case of cutaneous-visceral loxoscelismo with unfavorable evolution. El Loxoscelismo es producido por la picadura accidental de la araña del género Loxosceles, de distribución mundial. El envenenamiento puede ocasionar lesiones dermonecróticas y menos frecuentemente una enfermedad sistémica, que puede ser fatal El mecanismo de acción del veneno es multifactorial. Las características dermonecróticas resultan de efectos directos del veneno sobre las células y componentes de la membrana basal, como también sobre la matriz extracelular. La interacción inicial entre el veneno y los tejidos, causa activación del complemento, migración de polimorfonucleares neutrófilos, liberación de enzimas proteolíticas, citoquinas, agregación plaquetaria, y alteraciones del flujo sanguíneo que resultan en edema e isquemia, con desarrollo de necrosis.No hay un tratamiento definitivo para el loxoscelismo, sin embargo el uso precoz del antiveneno específico, disminuye el tamaño de la lesión y limita la enfermedad sistémica Presentamos un caso de loxoscelismo cutáneo-visceral con insuficiencia renal, y evolución desfavorable. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019-02-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/23570 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 65 No. 4 (2008); 127-137 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 65 Núm. 4 (2008); 127-137 Revista da Faculdade de Ciências Médicas de Córdoba; v. 65 n. 4 (2008); 127-137 1853-0605 0014-6722 10.31053/1853.0605.v65.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/23570/23255 Derechos de autor 2019 Universidad Nacional de Córdoba |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
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R-10 |
| container_title_str |
Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
insuficiencia renal veneno picadura de araña lesiones dermonecróticas hemólisis loxosceles laeta dermonecrotic lesions cutáneo-visceral lesions acute renal injury |
| spellingShingle |
insuficiencia renal veneno picadura de araña lesiones dermonecróticas hemólisis loxosceles laeta dermonecrotic lesions cutáneo-visceral lesions acute renal injury Alfaro, Flavia V. Dotto, Beatriz H. Sesin, Ana M. Prettini, Viviana Sesin, Jorge Aliciardi, Enrique Vergottini, Juan C. Gonzalez, Mauricio Loxosceles cutaneous-visceral hemolytic renal failure acute |
| topic_facet |
insuficiencia renal veneno picadura de araña lesiones dermonecróticas hemólisis loxosceles laeta dermonecrotic lesions cutáneo-visceral lesions acute renal injury |
| author |
Alfaro, Flavia V. Dotto, Beatriz H. Sesin, Ana M. Prettini, Viviana Sesin, Jorge Aliciardi, Enrique Vergottini, Juan C. Gonzalez, Mauricio |
| author_facet |
Alfaro, Flavia V. Dotto, Beatriz H. Sesin, Ana M. Prettini, Viviana Sesin, Jorge Aliciardi, Enrique Vergottini, Juan C. Gonzalez, Mauricio |
| author_sort |
Alfaro, Flavia V. |
| title |
Loxosceles cutaneous-visceral hemolytic renal failure acute |
| title_short |
Loxosceles cutaneous-visceral hemolytic renal failure acute |
| title_full |
Loxosceles cutaneous-visceral hemolytic renal failure acute |
| title_fullStr |
Loxosceles cutaneous-visceral hemolytic renal failure acute |
| title_full_unstemmed |
Loxosceles cutaneous-visceral hemolytic renal failure acute |
| title_sort |
loxosceles cutaneous-visceral hemolytic renal failure acute |
| description |
The Loxoscelism is caused by the bite of spider Loxosceles laeta gender, of worldwide distribution. The poisoning can cause lesions dermonecrotic and less frequently a systemic illness that can be fatal.The mechanism of venom action is multifactorial. The characteristic dermonecrotic lesion results from the direct effects of the venom on the celular and basal membrane components , as well as the extracelular matrix.The initial interaction between the poison and tissues, causes complement activation , migration of polymorphic neutrophils, liberation of proteolytic enzymes, cytoquines, aggregation platelet, and blood flow alterations that result in edema and ischemia, with development of necrosis. There is no a definitive treatment for loxoscelism. However, the value of specific antivenom, to decrease lesion size and limit systemic illness even when such administration is delayed. We present a case of cutaneous-visceral loxoscelismo with unfavorable evolution. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2019 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/23570 |
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