Lupus nephritis
Systemic Lupus erythematosus (SLE) is an autoimmune, multisystemic disease characterized by numerous patterns of clinical and immunological manifestations. One of the distinctive markers is the production of autoantibodies, especially to nuclear antigens that include double chain DNA (ds-DNA), histo...
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2009
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I10-R10-article-235652019-05-20T10:45:02Z Lupus nephritis Nefritis Lupica Alba, Paula B. Albiero, Eduardo H. Yorio, Marcelo A. Nefritis Lupica lupus eritematoso sistémico LES Systemic lupus erythematosus lupus nephritis Systemic Lupus erythematosus (SLE) is an autoimmune, multisystemic disease characterized by numerous patterns of clinical and immunological manifestations. One of the distinctive markers is the production of autoantibodies, especially to nuclear antigens that include double chain DNA (ds-DNA), histones and soluble ribonucleoproteins (RNP) and Sm antigen. Numerous factors contribute to the formation of these and these include: the loss of tolerance of B and T cells, an increase in concentration and an abnormal presentation of autoantibodies (e.g. nucleosomes), and defects in the clereance of apoptotic cells among others. The variability in these events influences the nature and organic commitment in SLE. El Lupus eritematoso sistémico (LES) es una enfermedad autoinmune, multisistémica que se caracteriza por numerosos patrones de manifestaciones clínicas e inmunológicas. Uno de los marcadores distintivos es la producción de autoanticuerpos, especialmente a antígenos nucleares que incluyen DNA doble cadena ( ds-DNA), histonas y ribonucleoproteínas solubles (RNP) y antígeno Sm. Numerosos factores contribuyen a la formación de los mismos y éstos incluyen: la pérdida de la tolerancia de las células B y T, un aumento de la concentración y una presentación anormal de autoantígenos (e.g. nucleosomas), y defectos en el clereance de células apoptóticas entre otros. La variabilidad en estos eventos influencian la naturaleza y el compromiso orgánico en el LES. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2009-10-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/23565 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 65 No. 3 (2008); 82-89 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 65 Núm. 3 (2008); 82-89 Revista da Faculdade de Ciências Médicas de Córdoba; v. 65 n. 3 (2008); 82-89 1853-0605 0014-6722 10.31053/1853.0605.v65.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/23565/23250 Derechos de autor 2019 Universidad Nacional de Córdoba |
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Universidad Nacional de Córdoba |
institution_str |
I-10 |
repository_str |
R-10 |
container_title_str |
Revistas de la UNC |
language |
Español |
format |
Artículo revista |
topic |
Nefritis Lupica lupus eritematoso sistémico LES Systemic lupus erythematosus lupus nephritis |
spellingShingle |
Nefritis Lupica lupus eritematoso sistémico LES Systemic lupus erythematosus lupus nephritis Alba, Paula B. Albiero, Eduardo H. Yorio, Marcelo A. Lupus nephritis |
topic_facet |
Nefritis Lupica lupus eritematoso sistémico LES Systemic lupus erythematosus lupus nephritis |
author |
Alba, Paula B. Albiero, Eduardo H. Yorio, Marcelo A. |
author_facet |
Alba, Paula B. Albiero, Eduardo H. Yorio, Marcelo A. |
author_sort |
Alba, Paula B. |
title |
Lupus nephritis |
title_short |
Lupus nephritis |
title_full |
Lupus nephritis |
title_fullStr |
Lupus nephritis |
title_full_unstemmed |
Lupus nephritis |
title_sort |
lupus nephritis |
description |
Systemic Lupus erythematosus (SLE) is an autoimmune, multisystemic disease characterized by numerous patterns of clinical and immunological manifestations. One of the distinctive markers is the production of autoantibodies, especially to nuclear antigens that include double chain DNA (ds-DNA), histones and soluble ribonucleoproteins (RNP) and Sm antigen. Numerous factors contribute to the formation of these and these include: the loss of tolerance of B and T cells, an increase in concentration and an abnormal presentation of autoantibodies (e.g. nucleosomes), and defects in the clereance of apoptotic cells among others. The variability in these events influences the nature and organic commitment in SLE. |
publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
publishDate |
2009 |
url |
https://revistas.unc.edu.ar/index.php/med/article/view/23565 |
work_keys_str_mv |
AT albapaulab lupusnephritis AT albieroeduardoh lupusnephritis AT yoriomarceloa lupusnephritis AT albapaulab nefritislupica AT albieroeduardoh nefritislupica AT yoriomarceloa nefritislupica |
first_indexed |
2022-08-20T01:26:21Z |
last_indexed |
2022-08-20T01:26:21Z |
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1770718989300793344 |