Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report

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Background: Gout is a metabolic disease by deposition of uric acid crystals, which undertakes joint and soft tissue in both acute and chronic stages. Is a rare event the onset of a tumor in the site of the lesion.Objective: To present a rare case of association between sarcoma and tophi.Methods: 83...

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Autores principales: Szlabi, Susana, Flores, Jorge O., L. de Diller, Ana, Cabrera, Marta B.
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2012
Materias:
gouty tophus
malignant fibrous histiocytoma
undifferentiated high grade pleomorphic sarcoma
tofo gotoso
fibrohistiocitoma maligno
arcoma pleomórfico indiferenciado
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/20886
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
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institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
topic gouty tophus
malignant fibrous histiocytoma
undifferentiated high grade pleomorphic sarcoma
tofo gotoso
fibrohistiocitoma maligno
arcoma pleomórfico indiferenciado
spellingShingle gouty tophus
malignant fibrous histiocytoma
undifferentiated high grade pleomorphic sarcoma
tofo gotoso
fibrohistiocitoma maligno
arcoma pleomórfico indiferenciado
Szlabi, Susana
Flores, Jorge O.
L. de Diller, Ana
Cabrera, Marta B.
Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
topic_facet gouty tophus
malignant fibrous histiocytoma
undifferentiated high grade pleomorphic sarcoma
tofo gotoso
fibrohistiocitoma maligno
arcoma pleomórfico indiferenciado
author Szlabi, Susana
Flores, Jorge O.
L. de Diller, Ana
Cabrera, Marta B.
author_facet Szlabi, Susana
Flores, Jorge O.
L. de Diller, Ana
Cabrera, Marta B.
author_sort Szlabi, Susana
title Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
title_short Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
title_full Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
title_fullStr Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
title_full_unstemmed Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
title_sort undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
description Background: Gout is a metabolic disease by deposition of uric acid crystals, which undertakes joint and soft tissue in both acute and chronic stages. Is a rare event the onset of a tumor in the site of the lesion.Objective: To present a rare case of association between sarcoma and tophi.Methods: 83 year old man who consulted for tumor in his left elbow about 40 years of evolution, which spontaneously started to hurt. With the presumptive diagnosis of tophi treated surgically. The lesion recurred after 60 days, reintervention and radiotherapy was performed for diagnosis of malignant mesenchymal tumor associated with tophi. At 10 months developed ipsilateral nodal metastases, died within 2 years of the initial consultation.Results: The diagnosis of the first material resected was tophi. In the reintervention material was diagnosed mesenchymal spindle cell high grade neoplasm associated with tophi; immunohistochemistry revealed: vimentin + / +, MYO D1 - / - ASMA - / -, FVIII - / -, A1ATT - / -, CD68-/ -, S100-/ - with final diagnosis the undifferentiated high grade pleomorphic sarcoma.Conclusions: It is uncommon for gouty tophi are associated with other diseases and even fewer do so to tumors. In the literature have reported three previous cases concurrent with neoplasms, which were angiosarcoma, giant cell tumor and malignant fibrous histiocytoma. The latter have a high tendency to recur locally and have ability to distant metastases, especially lung and regional lymph nodes.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2012
url https://revistas.unc.edu.ar/index.php/med/article/view/20886
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AT floresjorgeo undifferentiatedhighgradepleomorphicsarcomamalignantfibroushistiocytomaassociatedagoutytophusacasereport
AT ldedillerana undifferentiatedhighgradepleomorphicsarcomamalignantfibroushistiocytomaassociatedagoutytophusacasereport
AT cabreramartab undifferentiatedhighgradepleomorphicsarcomamalignantfibroushistiocytomaassociatedagoutytophusacasereport
AT szlabisusana sarcomapleomorficoindiferenciadodealtogradofibrohistiocitomamalignoasociadoatofogotosopresentaciondeuncaso
AT floresjorgeo sarcomapleomorficoindiferenciadodealtogradofibrohistiocitomamalignoasociadoatofogotosopresentaciondeuncaso
AT ldedillerana sarcomapleomorficoindiferenciadodealtogradofibrohistiocitomamalignoasociadoatofogotosopresentaciondeuncaso
AT cabreramartab sarcomapleomorficoindiferenciadodealtogradofibrohistiocitomamalignoasociadoatofogotosopresentaciondeuncaso
first_indexed 2022-08-20T01:25:34Z
last_indexed 2022-08-20T01:25:34Z
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spelling I10-R10-article-208862019-05-10T12:48:13Z Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report Sarcoma pleomórfico indiferenciado de alto grado/ fibrohistiocitoma maligno asociado a tofo gotoso. presentación de un caso Szlabi, Susana Flores, Jorge O. L. de Diller, Ana Cabrera, Marta B. gouty tophus malignant fibrous histiocytoma undifferentiated high grade pleomorphic sarcoma tofo gotoso fibrohistiocitoma maligno arcoma pleomórfico indiferenciado Background: Gout is a metabolic disease by deposition of uric acid crystals, which undertakes joint and soft tissue in both acute and chronic stages. Is a rare event the onset of a tumor in the site of the lesion.Objective: To present a rare case of association between sarcoma and tophi.Methods: 83 year old man who consulted for tumor in his left elbow about 40 years of evolution, which spontaneously started to hurt. With the presumptive diagnosis of tophi treated surgically. The lesion recurred after 60 days, reintervention and radiotherapy was performed for diagnosis of malignant mesenchymal tumor associated with tophi. At 10 months developed ipsilateral nodal metastases, died within 2 years of the initial consultation.Results: The diagnosis of the first material resected was tophi. In the reintervention material was diagnosed mesenchymal spindle cell high grade neoplasm associated with tophi; immunohistochemistry revealed: vimentin + / +, MYO D1 - / - ASMA - / -, FVIII - / -, A1ATT - / -, CD68-/ -, S100-/ - with final diagnosis the undifferentiated high grade pleomorphic sarcoma.Conclusions: It is uncommon for gouty tophi are associated with other diseases and even fewer do so to tumors. In the literature have reported three previous cases concurrent with neoplasms, which were angiosarcoma, giant cell tumor and malignant fibrous histiocytoma. The latter have a high tendency to recur locally and have ability to distant metastases, especially lung and regional lymph nodes. Antecedentes: La gota es una enfermedad metabólica por depósito de cristales de ácido úrico, que compromete articulaciones y tejidos blandos tanto en sus etapas agudas como crónicas. Constituye un suceso poco común la aparición de un tumor en el sitio propio de la lesión.Objetivo: presentar un caso de asociación infrecuente entre tofo gotoso y sarcoma. Material y métodos: hombre de 83 años que consultó por tumoración en codo izquierdo de aproximadamente 40 años de evolución, que comenzó a doler espontáneamente. Con la presunción diagnóstica de tofo gotoso se trató quirúrgicamente. La lesión recidivó a los 60 días, se realizó reintervención y radioterapia por diagnóstico de tumor mesenquimal maligno asociado a tofo gotoso. A los 10 meses desarrolló metástasis ganglionar homolateral, falleció antes de los 2 años de la consulta inicial.Resultados: El diagnóstico de la primer biopsia fue tofo gotoso. En el material de reintervención se diagnosticó tofo gotoso asociado a neoplasia mesenquimal fusocelular de alto grado; la inmunohistoquímica reveló: vimentina +/+, MYO D1 -/-, ASMA -/-, FVIII -/-, A1ATT -/-, CD68-/-, S100-/- con resultado diagnóstico final de sarcoma pleomórfico indiferenciado de alto grado.Conclusión: Es infrecuente que los tofos gotosos se asocien a otras enfermedades y menos que lo hagan a tumores. En la bibliografía se han reportado tres casos previos concurrentes con neoplasias, las cuales fueron angiosarcoma, tumor de células gigantes y fibrohistiocitoma maligno. Estos últimos tienen una alta tendencia a recidivar y poseen capacidad de dar metástasis, especialmente a pulmones y ganglios regionales. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2012-12-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/20886 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 69 No. 4 (2012); 224-227 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 69 Núm. 4 (2012); 224-227 Revista da Faculdade de Ciências Médicas de Córdoba; v. 69 n. 4 (2012); 224-227 1853-0605 0014-6722 10.31053/1853.0605.v69.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/20886/20492 Derechos de autor 2018 Universidad Nacional de Córdoba

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