Utility of mycophenolate mycophenolate mofetil in lupus nephritis

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Mofetil mycophenolate (MM) is an immunosuppressive agent that was initially used to prevent rejection in solid organ transplantation, and was later used to treat systemic autoimmune diseases. In Systemic Lupus Erythematosus (SLE) it was initially used for the treatment of Lupus Nephropathy (LN) and...

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Autores principales: Savio, Veronica, Alba, Paula, Babini, Alejandra M.
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2012
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/20885
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Revistas de la UNC de Universidad Nacional de Córdoba
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spelling I10-R10-article-208852019-05-10T12:48:13Z Utility of mycophenolate mycophenolate mofetil in lupus nephritis Utilidad del micofenolato de mofetilo en la nefritis lupica Savio, Veronica Alba, Paula Babini, Alejandra M. Mofetil mycophenolate (MM) is an immunosuppressive agent that was initially used to prevent rejection in solid organ transplantation, and was later used to treat systemic autoimmune diseases. In Systemic Lupus Erythematosus (SLE) it was initially used for the treatment of Lupus Nephropathy (LN) and is now considered an important alternative agent for LN refractory to other drugs as well as in induction therapy with promising results and lower toxicity1-3. The first studies were limited to describing series with small numbers of patients where MM was used to treat patients with Cyclophosphamide (CF) and Azathioprine (AZA) resistant disease with favorable results. Subsequently several randomised studies have shown satisfactory results in the treatment of LN in both induction of remission and maintenance compared to the use of CF and AZA6-9.The good results obtained in the treatment of NL led to the MM being used for the treatment of other manifestations of the disease, such as vasculitis, neurological, skin, haematological and signs or symptoms of disease activity in general. Micofenolato de Mofetilo (MM) es un agente inmunosupresor que fue inicialmente usado para prevenir el rechazo en trasplante de órganos sólidos, y que luego se utilizó para tratar enfermedades autoinmunes sistémicas. En el Lupus Eritematoso Sistémico (LES) se utilizó inicialmente para el tratamiento de la Nefropatía Lúpica (NL) y es considerado hoy un importante agente alternativo para la NL refractaria a otros fármacos así como en el tratamiento de inducción con resultados prometedores y menor toxicidad1-3. Los primeros estudios se limitaron a describir series con escaso número de pacientes donde MM se utilizó para tratar pacientes con enfermedad resistente al uso de Ciclofosfamida (CF) y Azatioprina (AZA) con resultados favorables. Posteriormente varios estudios randomizados demostraron resultados satisfactorios en el tratamiento de la NL tanto en la inducción de la remisión como en el mantenimiento, comparados con el uso de CF y AZA6-9.Los buenos resultados obtenidos en el tratamiento de la NL llevaron a que el MM comenzara a usarse para el tratamiento de otras manifestaciones de la enfermedad, tales como vasculitis, neurológicas, cutáneas, hematológicas y signos o síntomas de actividad de la enfermedad en general. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2012-12-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/20885 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 69 No. 4 (2012); 219-223 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 69 Núm. 4 (2012); 219-223 Revista da Faculdade de Ciências Médicas de Córdoba; v. 69 n. 4 (2012); 219-223 1853-0605 0014-6722 10.31053/1853.0605.v69.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/20885/20491 Derechos de autor 2018 Universidad Nacional de Córdoba
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
author Savio, Veronica
Alba, Paula
Babini, Alejandra M.
spellingShingle Savio, Veronica
Alba, Paula
Babini, Alejandra M.
Utility of mycophenolate mycophenolate mofetil in lupus nephritis
author_facet Savio, Veronica
Alba, Paula
Babini, Alejandra M.
author_sort Savio, Veronica
title Utility of mycophenolate mycophenolate mofetil in lupus nephritis
title_short Utility of mycophenolate mycophenolate mofetil in lupus nephritis
title_full Utility of mycophenolate mycophenolate mofetil in lupus nephritis
title_fullStr Utility of mycophenolate mycophenolate mofetil in lupus nephritis
title_full_unstemmed Utility of mycophenolate mycophenolate mofetil in lupus nephritis
title_sort utility of mycophenolate mycophenolate mofetil in lupus nephritis
description Mofetil mycophenolate (MM) is an immunosuppressive agent that was initially used to prevent rejection in solid organ transplantation, and was later used to treat systemic autoimmune diseases. In Systemic Lupus Erythematosus (SLE) it was initially used for the treatment of Lupus Nephropathy (LN) and is now considered an important alternative agent for LN refractory to other drugs as well as in induction therapy with promising results and lower toxicity1-3. The first studies were limited to describing series with small numbers of patients where MM was used to treat patients with Cyclophosphamide (CF) and Azathioprine (AZA) resistant disease with favorable results. Subsequently several randomised studies have shown satisfactory results in the treatment of LN in both induction of remission and maintenance compared to the use of CF and AZA6-9.The good results obtained in the treatment of NL led to the MM being used for the treatment of other manifestations of the disease, such as vasculitis, neurological, skin, haematological and signs or symptoms of disease activity in general.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2012
url https://revistas.unc.edu.ar/index.php/med/article/view/20885
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first_indexed 2022-08-20T01:25:34Z
last_indexed 2022-08-20T01:25:34Z
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