Lipid profile in early arthritis and its relation with inflammatory activity

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Cardiovascular risk is increased in Rheumatoid Arthritis and it is associated with higher morbility and mortality. Few studies have evaluated the lipid profile in early arthritis (EA). Aims: To study the lipid profile in patients with EA and its association with disease activity (DA). Methods: We st...

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Autores principales: Gobbi, Carla Andrea, Asbert, Paatricia, Alba, Paula Beatriz, Alessio, Daniela, Subils, Gisela, Dotto, Gladys, Demarchi, Marcela, Albiero, Eduardo Horacio, Salica, Daniel Antonio, Martínez, Felipe
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017
Materias:
arthritis
dyslipidemias
artritis
dislipidemias
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/16623
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
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institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
topic arthritis
dyslipidemias
artritis
dislipidemias
spellingShingle arthritis
dyslipidemias
artritis
dislipidemias
Gobbi, Carla Andrea
Asbert, Paatricia
Alba, Paula Beatriz
Alessio, Daniela
Subils, Gisela
Dotto, Gladys
Demarchi, Marcela
Albiero, Eduardo Horacio
Salica, Daniel Antonio
Martínez, Felipe
Lipid profile in early arthritis and its relation with inflammatory activity
topic_facet arthritis
dyslipidemias
artritis
dislipidemias
author Gobbi, Carla Andrea
Asbert, Paatricia
Alba, Paula Beatriz
Alessio, Daniela
Subils, Gisela
Dotto, Gladys
Demarchi, Marcela
Albiero, Eduardo Horacio
Salica, Daniel Antonio
Martínez, Felipe
author_facet Gobbi, Carla Andrea
Asbert, Paatricia
Alba, Paula Beatriz
Alessio, Daniela
Subils, Gisela
Dotto, Gladys
Demarchi, Marcela
Albiero, Eduardo Horacio
Salica, Daniel Antonio
Martínez, Felipe
author_sort Gobbi, Carla Andrea
title Lipid profile in early arthritis and its relation with inflammatory activity
title_short Lipid profile in early arthritis and its relation with inflammatory activity
title_full Lipid profile in early arthritis and its relation with inflammatory activity
title_fullStr Lipid profile in early arthritis and its relation with inflammatory activity
title_full_unstemmed Lipid profile in early arthritis and its relation with inflammatory activity
title_sort lipid profile in early arthritis and its relation with inflammatory activity
description Cardiovascular risk is increased in Rheumatoid Arthritis and it is associated with higher morbility and mortality. Few studies have evaluated the lipid profile in early arthritis (EA). Aims: To study the lipid profile in patients with EA and its association with disease activity (DA). Methods: We studied 31 patients with diagnosis of EA and a control group, with age, gender and cardiovascular risk factors matched, who were attended to Rheumatology Unit at Córdoba Hospital from January 2011 to May 2013. We evaluated demographic data, lipid profile and DA by DAS28. Results: 31 patients were included with mean age of 42.3 years old, 87% female , the cholesterol level was 191.9 mg/dl, HDL 54, LDL 115.8, Triglycerides 117,6; and 31 patients were included in the control group with average age of 42.7 years old, and cholesterol level of 198.7 mg / dl, HDL 56.9 LDL 122.6, Triglycerides 99.6 (p NS). Regards disease activity, in the low DA group the Cholesterol level was 196.3 , LDL 115.8, HDL 62 y triglycerides 95.17, and in the Moderate and High DA the Cholesterol level was 190 mg/ dl, LDL 115, HDL 52 y triglycerides 122,9 (p NS) CONCLUSIONS : The lipid profile was normal and it was not associated with DA in EA patients.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2017
url https://revistas.unc.edu.ar/index.php/med/article/view/16623
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first_indexed 2022-08-20T01:24:51Z
last_indexed 2022-08-20T01:24:51Z
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spelling I10-R10-article-166232019-05-20T10:36:47Z Lipid profile in early arthritis and its relation with inflammatory activity Prevalencia de dislipidemia en artritis temprana y su relación con actividad inflamatoria Gobbi, Carla Andrea Asbert, Paatricia Alba, Paula Beatriz Alessio, Daniela Subils, Gisela Dotto, Gladys Demarchi, Marcela Albiero, Eduardo Horacio Salica, Daniel Antonio Martínez, Felipe arthritis dyslipidemias artritis dislipidemias Cardiovascular risk is increased in Rheumatoid Arthritis and it is associated with higher morbility and mortality. Few studies have evaluated the lipid profile in early arthritis (EA). Aims: To study the lipid profile in patients with EA and its association with disease activity (DA). Methods: We studied 31 patients with diagnosis of EA and a control group, with age, gender and cardiovascular risk factors matched, who were attended to Rheumatology Unit at Córdoba Hospital from January 2011 to May 2013. We evaluated demographic data, lipid profile and DA by DAS28. Results: 31 patients were included with mean age of 42.3 years old, 87% female , the cholesterol level was 191.9 mg/dl, HDL 54, LDL 115.8, Triglycerides 117,6; and 31 patients were included in the control group with average age of 42.7 years old, and cholesterol level of 198.7 mg / dl, HDL 56.9 LDL 122.6, Triglycerides 99.6 (p NS). Regards disease activity, in the low DA group the Cholesterol level was 196.3 , LDL 115.8, HDL 62 y triglycerides 95.17, and in the Moderate and High DA the Cholesterol level was 190 mg/ dl, LDL 115, HDL 52 y triglycerides 122,9 (p NS) CONCLUSIONS : The lipid profile was normal and it was not associated with DA in EA patients. El riesgo cardiovascular está aumentado en pacientes con Artritis Reumatoidea establecida, con aumento de la morbimortalidad cardiovascular, inclusive tempranamente y puede ser expresión subclínica de la enfermedad. Pocos estudios han evaluado el perfil lipídico en artritis temprana (AT). OBJETIVOS: Determinar la prevalencia y el tipo de alteración del perfil lipídico en pacientes con AT y su  asociación con la actividad de la enfermedad (AE). MATERIAL Y MÉTODOS: Se estudiaron pacientes con diagnóstico de  AT comparados con un grupo control, apareados por sexo, edad y factores de riesgo cardiovascular, asistidos de forma consecutiva desde enero de 2011 a mayo de 2013 en el Hospital Córdoba. Se recolectaron datos demográficos, perfil lipídico y actividad de la enfermedad (AE) por Disease Activity Score (DAS 28). Se comparó el nivel de lípidos en ambos grupos y entre pacientes con artritis según el nivel de AE, clasificándolos en Baja AE y Mediana / Alta AE. P menor a 0.05 fue considerada significativa. RESULTADOS: El número de pacientes  con Artritis temprana fue de 31, con una media de edad de 42.3 años, 87% sexo femenino y el nivel de Colesterol Total promedio fue de 191.9 mg/dl, HDL 54, LDL 115.8, Triglicéridos 117,6, mientras que el grupo control fue de 31 pacientes con una media de edad de 42.7 años, con nivel promedio de Colesterol 198.7 mg/dl, HDL 56.9,  LDL 122.6, Triglicéridos 99.6 (p=NS, para todas las determinaciones). En cuanto a la actividad de la enfermedad, en el grupo de Baja AE los niveles de Colesterol fueron 196.3, LDL 115.8, HDL 62 y triglicéridos 95.17 y en el grupo moderada y alta AE, Colesterol 190,1 LDL 115, 8, HDL 52 y triglicéridos 122,9  (p NS para todas las comparaciones)CONCLUSIONES: El perfil lipídico fue normal y no se encontró asociado a la AE en pacientes con AT. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017-09-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/vnd.openxmlformats-officedocument.spreadsheetml.sheet https://revistas.unc.edu.ar/index.php/med/article/view/16623 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 74 No. 3 (2017); 256-262 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 74 Núm. 3 (2017); 256-262 Revista da Faculdade de Ciências Médicas de Córdoba; v. 74 n. 3 (2017); 256-262 1853-0605 0014-6722 10.31053/1853.0605.v74.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/16623/19272 https://revistas.unc.edu.ar/index.php/med/article/view/16623/26374 Derechos de autor 2017 Universidad Nacional de Córdoba

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