Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts

Mostrar todas las versiones(2)

Background: Plant extracts can be obtained to carry bioactive compounds, useful for prevention and treatment of different illnesses. This also supports the intake of teas as functional beverages. Nonetheless, it is incompletely known whether these extracts can act as effective sources and vehicles d...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Albrecht, Claudia, Guzmán, María Laura, Cittadini, María Cecilia, Canalis, Alejandra Mariel, Valentich, Mirta Ana, Olivera, María Eugenia, Soria, Elio Andrés
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017
Materias:
quebracho
Ilex paraguariensis
Lantana
absorción
oxidación-reducción
Quebracho
Absorption
Oxidation-Reduction
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/15412
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10-article-15412
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Inglés
format Artículo revista
topic quebracho
Ilex paraguariensis
Lantana
absorción
oxidación-reducción
Quebracho
Ilex paraguariensis
Lantana
Absorption
Oxidation-Reduction
spellingShingle quebracho
Ilex paraguariensis
Lantana
absorción
oxidación-reducción
Quebracho
Ilex paraguariensis
Lantana
Absorption
Oxidation-Reduction
Albrecht, Claudia
Guzmán, María Laura
Cittadini, María Cecilia
Canalis, Alejandra Mariel
Valentich, Mirta Ana
Olivera, María Eugenia
Soria, Elio Andrés
Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
topic_facet quebracho
Ilex paraguariensis
Lantana
absorción
oxidación-reducción
Quebracho
Ilex paraguariensis
Lantana
Absorption
Oxidation-Reduction
author Albrecht, Claudia
Guzmán, María Laura
Cittadini, María Cecilia
Canalis, Alejandra Mariel
Valentich, Mirta Ana
Olivera, María Eugenia
Soria, Elio Andrés
author_facet Albrecht, Claudia
Guzmán, María Laura
Cittadini, María Cecilia
Canalis, Alejandra Mariel
Valentich, Mirta Ana
Olivera, María Eugenia
Soria, Elio Andrés
author_sort Albrecht, Claudia
title Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
title_short Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
title_full Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
title_fullStr Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
title_full_unstemmed Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
title_sort bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
description Background: Plant extracts can be obtained to carry bioactive compounds, useful for prevention and treatment of different illnesses. This also supports the intake of teas as functional beverages. Nonetheless, it is incompletely known whether these extracts can act as effective sources and vehicles de phenolic compounds (phenolics/polyphenols) to reach their targets. Objective: To establish whether phytoextract ingestion modified in a sex-dependent manner the phenolic bioavailability and redox response in liver and kidney. Method: BALB/C mice ingested for a month 100 mg/Kg/d of extracts (tea-like) from Aspidosperma quebracho-blanco (AQB), Lantana grisebachii (LG) or Ilex paraguariensis (IP). Then, phenolics, peroxides and nitrites were analyzed by spectrophotometry. Also, phenolic permeation from digested and undigested extracts was evaluated in vitro with a rat jejunum-based assay. Results: Phenolic permeation depended on extract digestion. In males, IP showed a special time course of hepatic phenolics, whereas all extracts decreased renal phenolics at 15 days. Extracts induced hepatic lipoperoxides at 15 days. LG reduced renal hydroperoxides at 15 days and hepatic nitrites at 30 days, whereas AQB and IP reduced renal lipoperoxides and nitrites at 30 days. In females, extracts reduced hydroperoxides, with LG and AQB also reducing lipoperoxides. IP increased renal lipoperoxides at 30 days. Conclusion: IP was a relevant phenolic source. Sex-dependent responses were found in all variables, which should be considered to prevent misleading generalizations in phytodrug bioprospecting.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2017
url https://revistas.unc.edu.ar/index.php/med/article/view/15412
work_keys_str_mv AT albrechtclaudia bioavailabilityofphenoliccompoundsandredoxstateofmurineliverandkidneyassexdependentresponsestophytoextracts
AT guzmanmarialaura bioavailabilityofphenoliccompoundsandredoxstateofmurineliverandkidneyassexdependentresponsestophytoextracts
AT cittadinimariacecilia bioavailabilityofphenoliccompoundsandredoxstateofmurineliverandkidneyassexdependentresponsestophytoextracts
AT canalisalejandramariel bioavailabilityofphenoliccompoundsandredoxstateofmurineliverandkidneyassexdependentresponsestophytoextracts
AT valentichmirtaana bioavailabilityofphenoliccompoundsandredoxstateofmurineliverandkidneyassexdependentresponsestophytoextracts
AT oliveramariaeugenia bioavailabilityofphenoliccompoundsandredoxstateofmurineliverandkidneyassexdependentresponsestophytoextracts
AT soriaelioandres bioavailabilityofphenoliccompoundsandredoxstateofmurineliverandkidneyassexdependentresponsestophytoextracts
AT albrechtclaudia biodisponibilidaddecompuestosfenolicosyestadoredoxdehigadoyrinonderatoncomorespuestassexodependienteafitoextractos
AT guzmanmarialaura biodisponibilidaddecompuestosfenolicosyestadoredoxdehigadoyrinonderatoncomorespuestassexodependienteafitoextractos
AT cittadinimariacecilia biodisponibilidaddecompuestosfenolicosyestadoredoxdehigadoyrinonderatoncomorespuestassexodependienteafitoextractos
AT canalisalejandramariel biodisponibilidaddecompuestosfenolicosyestadoredoxdehigadoyrinonderatoncomorespuestassexodependienteafitoextractos
AT valentichmirtaana biodisponibilidaddecompuestosfenolicosyestadoredoxdehigadoyrinonderatoncomorespuestassexodependienteafitoextractos
AT oliveramariaeugenia biodisponibilidaddecompuestosfenolicosyestadoredoxdehigadoyrinonderatoncomorespuestassexodependienteafitoextractos
AT soriaelioandres biodisponibilidaddecompuestosfenolicosyestadoredoxdehigadoyrinonderatoncomorespuestassexodependienteafitoextractos
first_indexed 2022-08-20T01:24:46Z
last_indexed 2022-08-20T01:24:46Z
_version_ 1770718872656150528
spelling I10-R10-article-154122019-05-20T10:37:29Z Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts Biodisponibilidad de Compuestos Fenólicos y Estado Redox de hígado y riñón de ratón como respuestas sexo-dependiente a fitoextractos Albrecht, Claudia Guzmán, María Laura Cittadini, María Cecilia Canalis, Alejandra Mariel Valentich, Mirta Ana Olivera, María Eugenia Soria, Elio Andrés quebracho Ilex paraguariensis Lantana absorción oxidación-reducción Quebracho Ilex paraguariensis Lantana Absorption Oxidation-Reduction Background: Plant extracts can be obtained to carry bioactive compounds, useful for prevention and treatment of different illnesses. This also supports the intake of teas as functional beverages. Nonetheless, it is incompletely known whether these extracts can act as effective sources and vehicles de phenolic compounds (phenolics/polyphenols) to reach their targets. Objective: To establish whether phytoextract ingestion modified in a sex-dependent manner the phenolic bioavailability and redox response in liver and kidney. Method: BALB/C mice ingested for a month 100 mg/Kg/d of extracts (tea-like) from Aspidosperma quebracho-blanco (AQB), Lantana grisebachii (LG) or Ilex paraguariensis (IP). Then, phenolics, peroxides and nitrites were analyzed by spectrophotometry. Also, phenolic permeation from digested and undigested extracts was evaluated in vitro with a rat jejunum-based assay. Results: Phenolic permeation depended on extract digestion. In males, IP showed a special time course of hepatic phenolics, whereas all extracts decreased renal phenolics at 15 days. Extracts induced hepatic lipoperoxides at 15 days. LG reduced renal hydroperoxides at 15 days and hepatic nitrites at 30 days, whereas AQB and IP reduced renal lipoperoxides and nitrites at 30 days. In females, extracts reduced hydroperoxides, with LG and AQB also reducing lipoperoxides. IP increased renal lipoperoxides at 30 days. Conclusion: IP was a relevant phenolic source. Sex-dependent responses were found in all variables, which should be considered to prevent misleading generalizations in phytodrug bioprospecting. Antecedentes: Es posible obtener extractos vegetales que contengan compuestos bioactivos, aplicables en la prevención y el tratamiento de diferentes enfermedades. Esto apoya además el consumo de infusiones como bebidas funcionales. No obstante, no se conoce completamente si estos extractos son capaces de actuar como fuentes y vehículos efectivos de compuestos fenólicos (fenoles/polifenoles) para alcanzar sus blancos. Objetivo: Establecer si la ingestión de fitoextractos modifica de manera sexo-dependiente la biodisponibilidad de fenoles y la respuesta redox en hígado y riñón. Métodos: Ratones BALB/C consumieron durante un mes 100 mg/Kg/d de extracto (derivado de infusión), proveniente de Aspidosperma quebracho-blanco (AQB), Lantana grisebachii (LG) o Ilex paraguariensis (IP). Luego, se analizaron por espectrofotometría fenoles, peróxidos y nitritos. Además, se evaluó in vitro la absorción de fenoles de extractos digeridos y no digeridos con un ensayo que emplea yeyuno de rata. Resultados: La absorción de fenoles dependió de la digestión del extracto. En machos, IP mostró una curva temporal de fenoles hepáticos, mientras todos los extractos los disminuyeron a los 15 días. Los extractos indujeron lipoperóxidos hepáticos. LG redujo hidroperóxidos renales a los 15 días y nitritos hepáticos a los 30 días, mientras AQB e IP redujeron lipoperóxidos y nitritos en riñón a los 30. En hembras, los extractos disminuyeron los hidroperóxidos, con LG and AQB también reduciendo lipoperóxidos. IP incrementó lipoperóxidos renales tras 30 días. Conclusión: IP fue una fuente relevante de fenoles. Se hallaron respuestas sexo-dependientes en todas las variables, lo que debe ser considerado para evitar generalizaciones incorrectas en la bioprospección de drogas vegetales. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017-12-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/vnd.openxmlformats-officedocument.wordprocessingml.document image/tiff image/tiff image/tiff https://revistas.unc.edu.ar/index.php/med/article/view/15412 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 74 No. 4 (2017); 338-344 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 74 Núm. 4 (2017); 338-344 Revista da Faculdade de Ciências Médicas de Córdoba; v. 74 n. 4 (2017); 338-344 1853-0605 0014-6722 10.31053/1853.0605.v74.n4 eng https://revistas.unc.edu.ar/index.php/med/article/view/15412/19486 https://revistas.unc.edu.ar/index.php/med/article/view/15412/26226 https://revistas.unc.edu.ar/index.php/med/article/view/15412/26227 https://revistas.unc.edu.ar/index.php/med/article/view/15412/26228 https://revistas.unc.edu.ar/index.php/med/article/view/15412/26229 Derechos de autor 2017 Universidad Nacional de Córdoba

Ejemplares similares