Innate receptors and IL-17 in the immune response against human pathogenic fungi

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In recent years, the rise of human fungal infections has been associated to lack of early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions and immunosuppression induced by disease, are well known as risk factors...

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Autores principales: Miró, María Soledad, Vigezzi, Cecilia, Rodriguez, Emilse, Icely, Paula Alejandra, Caeiro, Juan Pablo, Riera, Fernando Oscar, Masih, Diana Teresa, Sotomayor, Claudia Elena
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018
Materias:
Human fungal infections
antifungal immunity
innate receptors
Dectin-1
Inflamasommes
IL-17
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/13353
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10-article-13353
record_format ojs
spelling I10-R10-article-133532018-08-22T09:03:10Z Innate receptors and IL-17 in the immune response against human pathogenic fungi Miró, María Soledad Vigezzi, Cecilia Rodriguez, Emilse Icely, Paula Alejandra Caeiro, Juan Pablo Riera, Fernando Oscar Masih, Diana Teresa Sotomayor, Claudia Elena Human fungal infections antifungal immunity innate receptors Dectin-1 Inflamasommes IL-17 In recent years, the rise of human fungal infections has been associated to lack of early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions and immunosuppression induced by disease, are well known as risk factors for these pathologies. Cells of the innate immune system are equipped with surface and cytoplasmic receptors for recognition of microorganisms called pattern recognition receptors (PRRs). PRRs recognize specific pathogen-associated molecular patterns (PAMPs) that are crucial for the activation and killing of pathogenic fungi by immune system.  This review will outline the PRRs and cells required for effective antifungal immunity, with a special focus on the major antifungal cytokine IL-17. Finally, naturally occurring human mutations involved in the increased susceptibility to fungal infections are also discussed Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018-08-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf image/gif image/gif image/jpeg https://revistas.unc.edu.ar/index.php/med/article/view/13353 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 73 No. 3 (2016) Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 73 Núm. 3 (2016) Revista da Faculdade de Ciências Médicas de Córdoba; v. 73 n. 3 (2016) 1853-0605 0014-6722 10.31053/1853.0605.v73.n3 eng https://revistas.unc.edu.ar/index.php/med/article/view/13353/25865 https://revistas.unc.edu.ar/index.php/med/article/view/13353/25866 https://revistas.unc.edu.ar/index.php/med/article/view/13353/25867 https://revistas.unc.edu.ar/index.php/med/article/view/13353/25868 Derechos de autor 2018 Universidad Nacional de Córdoba
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Inglés
format Artículo revista
topic Human fungal infections
antifungal immunity
innate receptors
Dectin-1
Inflamasommes
IL-17
spellingShingle Human fungal infections
antifungal immunity
innate receptors
Dectin-1
Inflamasommes
IL-17
Miró, María Soledad
Vigezzi, Cecilia
Rodriguez, Emilse
Icely, Paula Alejandra
Caeiro, Juan Pablo
Riera, Fernando Oscar
Masih, Diana Teresa
Sotomayor, Claudia Elena
Innate receptors and IL-17 in the immune response against human pathogenic fungi
topic_facet Human fungal infections
antifungal immunity
innate receptors
Dectin-1
Inflamasommes
IL-17
author Miró, María Soledad
Vigezzi, Cecilia
Rodriguez, Emilse
Icely, Paula Alejandra
Caeiro, Juan Pablo
Riera, Fernando Oscar
Masih, Diana Teresa
Sotomayor, Claudia Elena
author_facet Miró, María Soledad
Vigezzi, Cecilia
Rodriguez, Emilse
Icely, Paula Alejandra
Caeiro, Juan Pablo
Riera, Fernando Oscar
Masih, Diana Teresa
Sotomayor, Claudia Elena
author_sort Miró, María Soledad
title Innate receptors and IL-17 in the immune response against human pathogenic fungi
title_short Innate receptors and IL-17 in the immune response against human pathogenic fungi
title_full Innate receptors and IL-17 in the immune response against human pathogenic fungi
title_fullStr Innate receptors and IL-17 in the immune response against human pathogenic fungi
title_full_unstemmed Innate receptors and IL-17 in the immune response against human pathogenic fungi
title_sort innate receptors and il-17 in the immune response against human pathogenic fungi
description In recent years, the rise of human fungal infections has been associated to lack of early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions and immunosuppression induced by disease, are well known as risk factors for these pathologies. Cells of the innate immune system are equipped with surface and cytoplasmic receptors for recognition of microorganisms called pattern recognition receptors (PRRs). PRRs recognize specific pathogen-associated molecular patterns (PAMPs) that are crucial for the activation and killing of pathogenic fungi by immune system.  This review will outline the PRRs and cells required for effective antifungal immunity, with a special focus on the major antifungal cytokine IL-17. Finally, naturally occurring human mutations involved in the increased susceptibility to fungal infections are also discussed
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2018
url https://revistas.unc.edu.ar/index.php/med/article/view/13353
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first_indexed 2022-08-20T01:24:32Z
last_indexed 2022-08-20T01:24:32Z
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