Evolution of linear motifs within the papillomavirus E7 oncoprotein
Many protein functions can be traced to linear sequence motifs of less than five residues, which are often found within intrinsically disordered domains. In spite of their prevalence, their role in protein evolution is only beginning to be understood. The study of papillomaviruses has provided many...
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2012
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| LEADER | 17828caa a22015257a 4500 | ||
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| 001 | PAPER-9319 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203914.0 | ||
| 008 | 190411s2012 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84865074702 | |
| 024 | 7 | |2 cas |a Papillomavirus E7 Proteins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JMOBA | ||
| 100 | 1 | |a Chemes, L.B. | |
| 245 | 1 | 0 | |a Evolution of linear motifs within the papillomavirus E7 oncoprotein |
| 260 | |c 2012 | ||
| 270 | 1 | 0 | |m De Prat-Gay, G.; Protein Structure-Function and Engineering Laboratory, Fundación Instituto Leloir, IIBBA-CONICET, Patricias Argentinas 435 (1405), Buenos Aires, Argentina; email: gpg@leloir.org.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Many protein functions can be traced to linear sequence motifs of less than five residues, which are often found within intrinsically disordered domains. In spite of their prevalence, their role in protein evolution is only beginning to be understood. The study of papillomaviruses has provided many insights on the evolution of protein structure and function. We have chosen the papillomavirus E7 oncoprotein as a model system for the evolution of functional linear motifs. The multiple functions of E7 proteins from paradigmatic papillomavirus types can be explained to a large extent in terms of five linear motifs within the intrinsically disordered N-terminal domain and two linear motifs within the globular homodimeric C-terminal domain. We examined the motif inventory of E7 proteins from over 200 known papillomavirus types and found that the motifs reported for paradigmatic papillomavirus types are absent from many uncharacterized E7 proteins. Several motif pairs occur more often than expected, suggesting that linear motifs may evolve and function in a cooperative manner. The E7 linear motifs have appeared or disappeared multiple times during papillomavirus evolution, confirming the evolutionary plasticity of short functional sequences. Four of the motifs appeared several times during papillomavirus evolution, providing direct evidence for convergent evolution. Interestingly, the evolution pattern of a motif is independent of its location in a globular or disordered domain. The correlation between the presence of some motifs and virus host specificity and tissue tropism suggests that linear motifs play a role in the adaptive evolution of papillomaviruses. © 2012 Elsevier Ltd. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Instituto Nacional del Cáncer | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, PICT 2010-1052 | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, UBACyT 20020090200727 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: PICT 2006-223, PICT 2007-2202 | ||
| 536 | |a Detalles de la financiación: We acknowledge funding from Agencia Nacional de Promoción Científica y Tecnológica ( PICT 2010-1052 to I.E.S. and PICT 2006-223 and PICT 2007-2202 to J.F.), Universidad de Buenos Aires ( UBACyT 20020090200727 to J.F.), Consejo Nacional de Investigaciones Científicas y Técnicas (postdoctoral fellowship to L.B.C.; J.F., G.d.P.G., and I.E.S. are CONICET career investigators,) and Instituto Nacional del Cáncer (graduate fellowship to J.G.). We thank Ignacio G. Bravo, Robert Burk, and Zigui Chen for kindly providing PV phylogenetic trees. Appendix A | ||
| 593 | |a Protein Structure-Function and Engineering Laboratory, Fundación Instituto Leloir, IIBBA-CONICET, Patricias Argentinas 435 (1405), Buenos Aires, Argentina | ||
| 593 | |a Protein Physiology Laboratory, Departamento de Química Biológica, Ciudad Universitaria, Intendente Güiraldes 2160, 1428 Buenos Aires, Argentina | ||
| 593 | |a División Herpetología, Museo Argentino de Ciencias Naturales-CONICET, Ángel Gallardo 470, C1405DJR, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ADAPTIVE EVOLUTION |
| 690 | 1 | 0 | |a CONVERGENT EVOLUTION |
| 690 | 1 | 0 | |a INTRINSIC DISORDER |
| 690 | 1 | 0 | |a SEQUENCE MOTIF |
| 690 | 1 | 0 | |a HOMODIMER |
| 690 | 1 | 0 | |a PROTEIN E7 |
| 690 | 1 | 0 | |a AMINO TERMINAL SEQUENCE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CARBOXY TERMINAL SEQUENCE |
| 690 | 1 | 0 | |a CONVERGENT EVOLUTION |
| 690 | 1 | 0 | |a ENZYME PHOSPHORYLATION |
| 690 | 1 | 0 | |a GENE MUTATION |
| 690 | 1 | 0 | |a GENETIC VARIABILITY |
| 690 | 1 | 0 | |a MOLECULAR EVOLUTION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PAPILLOMA VIRUS |
| 690 | 1 | 0 | |a PAPILLOMAVIRUS INFECTION |
| 690 | 1 | 0 | |a PDZ DOMAIN |
| 690 | 1 | 0 | |a PHENOTYPE |
| 690 | 1 | 0 | |a PHYLOGENY |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN DOMAIN |
| 690 | 1 | 0 | |a PROTEIN FUNCTION |
| 690 | 1 | 0 | |a PROTEIN MOTIF |
| 690 | 1 | 0 | |a VIRAL TROPISM |
| 690 | 1 | 0 | |a VIRUS CELL INTERACTION |
| 690 | 1 | 0 | |a VIRUS VIRULENCE |
| 690 | 1 | 0 | |a AMINO ACID MOTIFS |
| 690 | 1 | 0 | |a AMINO ACID SEQUENCE |
| 690 | 1 | 0 | |a EVOLUTION, MOLECULAR |
| 690 | 1 | 0 | |a MOLECULAR SEQUENCE DATA |
| 690 | 1 | 0 | |a PAPILLOMAVIRIDAE |
| 690 | 1 | 0 | |a PAPILLOMAVIRUS E7 PROTEINS |
| 690 | 1 | 0 | |a PROTEIN STRUCTURE, TERTIARY |
| 690 | 1 | 0 | |a SEQUENCE ALIGNMENT |
| 690 | 1 | 0 | |a PAPILLOMAVIRIDAE |
| 650 | 1 | 7 | |2 spines |a VIRUS |
| 700 | 1 | |a Glavina, J. | |
| 700 | 1 | |a Faivovich, J. | |
| 700 | 1 | |a De Prat-Gay, G. | |
| 700 | 1 | |a Sánchez, I.E. | |
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