Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats
The effect of hexachlorobenzene (HCB) (1 g/kg bw) administration for 4 weeks, on thyroxine (T4) and triiodothyronine (T3) metabolism was studied in Wistar rats. The effect on serum binding of T4 has also been studied. Animals were injected with a tracer dose of either labeled hormone and by examinin...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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1989
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 08126caa a22009497a 4500 | ||
|---|---|---|---|
| 001 | PAPER-664 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203000.0 | ||
| 008 | 190411s1989 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0024841326 | |
| 024 | 7 | |2 cas |a hexachlorobenzene, 118-74-1, 55600-34-5; liothyronine, 6138-47-2, 6893-02-3; thyrotropin, 9002-71-5; thyroxine, 7488-70-2; Blood Proteins; Chlorobenzenes; Hexachlorobenzene, 118-74-1; Iodine Radioisotopes; Thyroxine, 7488-70-2; Triiodothyronine, 6893-02-3 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Kleiman de Pisarev, D.L. | |
| 245 | 1 | 0 | |a Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats |
| 260 | |c 1989 | ||
| 270 | 1 | 0 | |m de Pisarev, D.L.K.Vidal 2483, 8°B, Buenos Aires, 1428, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Barsano, C.P., Environmental factors altering thyroid function and their assessment (1981) Environ. Health Perspect., 38, p. 71 | ||
| 504 | |a Cavalieri, R.R., Pitt-Rivers, R., The effects of drugs on the distribution and metabolism of thyroid hormones (1981) Pharmacol. Rev., 33, p. 55 | ||
| 504 | |a United States Environmental Protection Agency Health Assessment Document for chlorinated benzenes, EPA/600/8-84/015F, 1985; Cabrai J.R.P., Shubik P. Carcinogenic activity of hexachlorobenzene in mice and hamsters. In: Morris, C.R. and Cabrai, J.R.P. (Eds.), Hexachlorobenzene: Proceedings of an international symposium. IARC Scientific Publications, Lyon, 1986, No 77, p. 411; Cabrai, J.R., Shubik, P., Moller, T., Ractano, F., Carcinogenic activity of hexachlorobenzene in hamsters (1977) Nature, 269, p. 510 | ||
| 504 | |a Cripps, D.J., Peters, H.A., Gocmen, A., Doqramaci, I., Porphyria Turcica due to hexachlorobenzene: a 20 to 30 year follow-up study on 204 patients (1984) Br. J. Dermatol., 111, p. 413 | ||
| 504 | |a Collins, W.T., Capen, C.C., Kasza, L., Carter, C., Dailey, R.E., Effect of polychlorinated biphenyl (PCB) on the thyroid gland of rats (1977) Am. J. Pathol., 89, p. 119 | ||
| 504 | |a Rozman, K., Gorski, J.R., Rozman, P., Parkinson, A., Reduced serum thyroid hormone levels in hexacloro-benzene induced porphyria (1986) Toxicology Lett., 30, p. 71 | ||
| 504 | |a Grupta, B.N., Mc Connell, E.E., Goldstein, J.A., Harris, M.W., Moore, J.A., Effect of a polybrominated biphenyl mixture in the rat and mouse (1983) Toxicol. Appl. Pharmacol., 68, p. 1 | ||
| 504 | |a Rall, J.E., Robbins, J., Lewallen, C.G., The thyroid (1964) The Hormones, p. 159. , G., Pincus, K.V., Thimann, E.B., Astwood, Academic Press Inc., New York | ||
| 504 | |a Oppenheimer, J.H., Schwartz, H.C., Shapiro, H.G., Bernstein, G., Surks, M.I., Differences in primary cellular factors influencing the metabolism and distribution of 3,5,3′-L-triiodothyronine and L-thyroxine (1970) J. Clin. Invest., 49, p. 1016 | ||
| 504 | |a Boado, R., Ulloa, E., Zaninovich, A.A., Reciprocal effects of an acute load of thyroxine or triiodothyronine on their peripheral metabolism and deiodination in the cold-acclimated rat (1982) J. Endocrinol. Invest., 5, p. 217 | ||
| 504 | |a Oppenheimer, J.H., Bernstein, G., Surks, M.I., Increased thyroxine turnover and thyroidal function after stimulation of hepto-cellular binding of thyroxine by phenobarbital (1968) J. Clin. Invest., 47, p. 1399 | ||
| 504 | |a Rozman, K., Gorski, J.R., Rozman, P., Parkinson, A., Reduced serum thyroid hormone levels in hexachlorobenzene induced porphyria (1986) Toxicology Lett., 30, p. 71 | ||
| 504 | |a Mart, ; Newman, W.C., Fernández, R.C., Slayden, R.M., Moon, R.C., Accelerated biliary thyroxine secretion in rats treated with 3-methylcholantrene (36015) (1971) Proc. Soc. Exp. Biol. Med., 138, p. 899 | ||
| 504 | |a Newman, W.C., Moon, R.C., Altered thyroxine metabolism resulting from the chemical carcinogen 3-methylcholantrene (1967) Endocrinology, 80, p. 896 | ||
| 504 | |a Bastoky, C.H., Enhanced thyroxine metabolism and high uptake goiters in rats after a single dose of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (1977) Endocrinology, 101, p. 292 | ||
| 504 | |a Lucier, G.W., McDaniel, O.C., Hook, G.E.R., Nature of the enhancement of hepatic uridine diphosphate glucuronyltransferase activity by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in rats (1975) Biochem. Pharmacol., 24, p. 325 | ||
| 504 | |a Bastoky, C.H., Murthy, P.V.N., Enhanced “in vitro” hepatic glucuronidation of T4 in rats following cutaneous application or ingestion of polychlorinated biphenyls (1976) Can. J. Physiol. Pharmacol., 54, p. 23 | ||
| 504 | |a Nikolaev, V., Naydenova, E., Kerimova, M., Dimov, S., Ivanov, E., Rat liver plasma membrane damage in hexachloro-benzene intoxication and its potentiation by ethanol (1986) Toxicology Lett., 32, p. 269 | ||
| 504 | |a Cullen, J.M., Doherty, G.F., Ingbar, S.H., The effect of hypothyroidism and thyrotoxicosis on thyroxine metabolism in the rat (1973) Endocrinology, 92, p. 1028 | ||
| 504 | |a Gómez Catalán, J., To-Figueras, J., Planas, J., Rodamilans, M., Corbella, J., Pentachlorophenol and hexachlorobenzene in serum and urine of the population of Barcelona (1987) Human Toxicol., 6, p. 397 | ||
| 520 | 3 | |a The effect of hexachlorobenzene (HCB) (1 g/kg bw) administration for 4 weeks, on thyroxine (T4) and triiodothyronine (T3) metabolism was studied in Wistar rats. The effect on serum binding of T4 has also been studied. Animals were injected with a tracer dose of either labeled hormone and by examining serum L-125I-T4 and L-125-I-T3, kinetics of radiolabeled hormones metabolism were calculated. The T4 metabolic clearance (MCI) as well as the distribution space, were increased by 6 fold. Decreased serum T4 levels result from an increase both in deiodinative and fecal disposal in HCB-treated rats. 125I-T3 metabolism was slightly affected. The enhanced peripheral disposition of thyroxine appears to lead to increased thyroid function, as measured by augmented TSH serum levels and 125I-thyroidal uptake. Serum binding of T4 was not affected. © 1989, Italian Society of Endocrinology (SIE). All rights reserved. |l eng | |
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos, Aires, Argentina | ||
| 593 | |a Vidal 2483, 8°B, Buenos Aires, 1428, Argentina | ||
| 690 | 1 | 0 | |a DEIODINATION |
| 690 | 1 | 0 | |a HEXACHLOROBENZENE |
| 690 | 1 | 0 | |a INTOXICATION |
| 690 | 1 | 0 | |a THYROID HORMONES |
| 690 | 1 | 0 | |a THYROXINE |
| 690 | 1 | 0 | |a TRIIODOTHYRONINE |
| 690 | 1 | 0 | |a HEXACHLOROBENZENE |
| 690 | 1 | 0 | |a LIOTHYRONINE |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a THYROTROPIN |
| 690 | 1 | 0 | |a THYROXINE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a DEIODINATION |
| 690 | 1 | 0 | |a INTOXICATION |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a METABOLIC CLEARANCE RATE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BLOOD PROTEINS |
| 690 | 1 | 0 | |a CHLOROBENZENES |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HEXACHLOROBENZENE |
| 690 | 1 | 0 | |a IODINE RADIOISOTOPES |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a THYROID GLAND |
| 690 | 1 | 0 | |a THYROXINE |
| 690 | 1 | 0 | |a TRIIODOTHYRONINE |
| 700 | 1 | |a Sancovich, H.A. | |
| 700 | 1 | |a Ferramola de Sancovich, A.M. | |
| 773 | 0 | |d 1989 |g v. 12 |h pp. 767-772 |k n. 11 |p J. Endocrinol. Invest. |x 03914097 |t Journal of Endocrinological Investigation | |
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| 856 | 4 | 0 | |u https://doi.org/10.1007/BF03350056 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03914097_v12_n11_p767_KleimandePisarev |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03914097_v12_n11_p767_KleimandePisarev |y Registro en la Biblioteca Digital |
| 961 | |a paper_03914097_v12_n11_p767_KleimandePisarev |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 61617 | ||