Coupling transcription and alternative splicing.
Alternative splicing regulation not only depends on the interaction of splicing factors with splicing enhancers and silencers in the pre-mRNA, but also on the coupling between transcription and splicing. This coupling is possible because splicing is often cotranscriptional and promoter identity and...
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| Autor principal: | |
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2007
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 02933caa a22004697a 4500 | ||
|---|---|---|---|
| 001 | PAPER-6219 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230607131851.0 | ||
| 008 | 190411s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-42449089029 | |
| 024 | 7 | |2 cas |a Chromatin; RNA Polymerase II, EC 2.7.7.- | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Kornblihtt, A.R. | |
| 245 | 1 | 0 | |a Coupling transcription and alternative splicing. |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Kornblihtt, A.R.email: ark@fbmc.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a Alternative splicing regulation not only depends on the interaction of splicing factors with splicing enhancers and silencers in the pre-mRNA, but also on the coupling between transcription and splicing. This coupling is possible because splicing is often cotranscriptional and promoter identity and occupation may affect alternative splicing. We discuss here the different mechanisms by which transcription regulates alternative splicing. These include the recruitment of splicing factors to the transcribing polymerase and "kinetic coupling", which involves changes in the rate of transcriptional elongation that in turn affect the timing in which splice sites are presented to the splicing machinery. The recruitment mechanism may depend on the particular features of the carboxyl terminal domain of RNA polymerase II, whereas kinetic coupling seems to be linked to how changes in chromatin structure and other factors affect transcription elongation. |l eng | |
| 593 | |a Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a RNA POLYMERASE II |
| 690 | 1 | 0 | |a ALTERNATIVE RNA SPLICING |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CHROMATIN |
| 690 | 1 | 0 | |a GENETIC TRANSCRIPTION |
| 690 | 1 | 0 | |a GENETICS |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a REVIEW |
| 690 | 1 | 0 | |a ALTERNATIVE SPLICING |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CHROMATIN |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a RNA POLYMERASE II |
| 690 | 1 | 0 | |a TRANSCRIPTION, GENETIC |
| 773 | 0 | |d 2007 |g v. 623 |h pp. 175-189 |p Adv. Exp. Med. Biol. |x 00652598 |t Advances in experimental medicine and biology | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-42449089029&partnerID=40&md5=7d76e0a2295521ebdcf6fd75a6ee8686 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00652598_v623_n_p175_Kornblihtt |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00652598_v623_n_p175_Kornblihtt |y Registro en la Biblioteca Digital |
| 961 | |a paper_00652598_v623_n_p175_Kornblihtt |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 67172 | ||