Cellular inactivation and antitumor efficacy of a new zinc phthalocyanine with potential use in photodynamic therapy
The aim of the present study was to evaluate the photodynamic efficacy of a novel phthalocyanine derivate 2,3,9,10,16,17,23,24-octakis[(N,N-dimethylamino) ethylsulfanyl]phthalocyaninatozinc(II) (referred here as S1) using MCF-7c3 human breast cancer cells and the LM2 adenocarcinoma subcutaneously im...
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2008
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| LEADER | 19728caa a22018257a 4500 | ||
|---|---|---|---|
| 001 | PAPER-6027 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203542.0 | ||
| 008 | 140217s2008 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-48949116924 | |
| 024 | 7 | |2 pubmed |a 18440266 | |
| 024 | 7 | |2 cas |a dimyristoylphosphatidylcholine, 13699-48-4, 18194-24-6; phthalocyanine zinc, 14320-04-8; Culture Media; Indoles; Organometallic Compounds; Solutions; Zn(II)-phthalocyanine, 14320-04-8 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a IJBBF | ||
| 100 | 1 | |a Vittar, N.B.R. | |
| 245 | 1 | 0 | |a Cellular inactivation and antitumor efficacy of a new zinc phthalocyanine with potential use in photodynamic therapy |
| 260 | |c 2008 | ||
| 270 | 1 | 0 | |m Rivarola, V.A.; Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Agencia Postal Nro 3, 5800 Rio Cuarto, Cordoba, Argentina; email: vrivarola@exa.unrc.edu.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The aim of the present study was to evaluate the photodynamic efficacy of a novel phthalocyanine derivate 2,3,9,10,16,17,23,24-octakis[(N,N-dimethylamino) ethylsulfanyl]phthalocyaninatozinc(II) (referred here as S1) using MCF-7c3 human breast cancer cells and the LM2 adenocarcinoma subcutaneously implanted in Balb/c mice as experimental models. The S1-l-α-dimyristoyl-phosphatidylcholine liposome was selected as the best delivery system because it showed greater internalization into cells (35 nmol/106 cells), relative to other liposomes. After 3 h incubation S1 was partially localized in lysosomes, the compartment that represented its primary photodamage site. The S1 treated cultures also revealed a degree of mitochondrial morphology alteration. Indeed, S1 leads to photokilling of the cells with different efficacies indicating that cell photoinactivation was dependent on both the phthalocyanine concentration and the light dose applied. Analyses of morphology and nuclear condensation level indicated that some of the cells exposed to photodynamic therapy were undergoing apoptosis within 8 h after treatment. To assess the in vivo effectiveness of S1, animals bearing tumors were treated with 0.2 mg/kg S1 followed 24 h later by 108 J cm-2 light at 600-800 nm and 60 mW cm-2,while other animals served as controls (no treatment, light alone, or S1 alone). All S1 treated tumors and none of the controls exhibited complete or partial responses, and these responses continued for the entire observation period of 12 days. Evaluation of tumor size showed that the treatment effectively delayed tumor growth. Light microscopy investigations of irradiated tumor specimens showed that S1 causes an early direct damage of malignant cells, largely via processes leading to random necrotic pathways. © 2008 Elsevier Ltd. All rights reserved. |l eng | |
| 593 | |a Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Agencia Postal Nro 3, 5800 Rio Cuarto, Cordoba, Argentina | ||
| 593 | |a Departamento de Química Orgánica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a CANCER |
| 690 | 1 | 0 | |a PHOTODYNAMIC THERAPY |
| 690 | 1 | 0 | |a PHOTOSENSITIZER |
| 690 | 1 | 0 | |a DIMYRISTOYLPHOSPHATIDYLCHOLINE |
| 690 | 1 | 0 | |a LIPOSOME |
| 690 | 1 | 0 | |a PHTHALOCYANINE ZINC |
| 690 | 1 | 0 | |a ADENOCARCINOMA |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ANTINEOPLASTIC ACTIVITY |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BREAST CANCER |
| 690 | 1 | 0 | |a CANCER CELL CULTURE |
| 690 | 1 | 0 | |a CANCER INHIBITION |
| 690 | 1 | 0 | |a CELL ACTIVATION |
| 690 | 1 | 0 | |a CELL DAMAGE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOLYSIS |
| 690 | 1 | 0 | |a DRUG DELIVERY SYSTEM |
| 690 | 1 | 0 | |a DRUG DISTRIBUTION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a INCUBATION TIME |
| 690 | 1 | 0 | |a INTERNALIZATION |
| 690 | 1 | 0 | |a LIGHT DAMAGE |
| 690 | 1 | 0 | |a LIGHT IRRADIANCE |
| 690 | 1 | 0 | |a LYSOSOME |
| 690 | 1 | 0 | |a MICROSCOPY |
| 690 | 1 | 0 | |a MITOCHONDRION |
| 690 | 1 | 0 | |a MORPHOLOGY |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PHOTODYNAMIC THERAPY |
| 690 | 1 | 0 | |a PHOTODYNAMICS |
| 690 | 1 | 0 | |a TREATMENT RESPONSE |
| 690 | 1 | 0 | |a TUMOR VOLUME |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CELL DEATH |
| 690 | 1 | 0 | |a CELL LINE, TUMOR |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a CULTURE MEDIA |
| 690 | 1 | 0 | |a DARKNESS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a INTRACELLULAR SPACE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a NEOPLASMS |
| 690 | 1 | 0 | |a ORGANOMETALLIC COMPOUNDS |
| 690 | 1 | 0 | |a PHOTOCHEMOTHERAPY |
| 690 | 1 | 0 | |a SOLUTIONS |
| 690 | 1 | 0 | |a SPECTROMETRY, FLUORESCENCE |
| 690 | 1 | 0 | |a TREATMENT OUTCOME |
| 690 | 1 | 0 | |a XENOGRAFT MODEL ANTITUMOR ASSAYS |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a MUS |
| 650 | 1 | 7 | |2 spines |a NECROSIS |
| 650 | 1 | 7 | |2 spines |a INDOLES |
| 700 | 1 | |a Prucca, C.G. | |
| 700 | 1 | |a Strassert, C. | |
| 700 | 1 | |a Awruch, J. | |
| 700 | 1 | |a Rivarola, V.A. | |
| 773 | 0 | |d 2008 |g v. 40 |h pp. 2192-2205 |k n. 10 |p Int. J. Biochem. Cell Biol. |x 13572725 |w (AR-BaUEN)CENRE-5218 |t International Journal of Biochemistry and Cell Biology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/j.biocel.2008.02.024 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_13572725_v40_n10_p2192_Vittar |y Handle |
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