Increased splenocyte proliferative response and cytokine production in β-endorphin-deficient mice
We used β-endorphin-deficient mice as a novel approach to confirm the physiological role that opioid peptides play in the development or regulation of the immune system. We found that mice lacking β-endorphin possessed an enhanced immune response, measured in terms of splenocyte proliferation and in...
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| Formato: | Capítulo de libro |
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2002
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| LEADER | 22934caa a22020537a 4500 | ||
|---|---|---|---|
| 001 | PAPER-5210 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203451.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0036789965 | |
| 024 | 7 | |2 cas |a Adrenocorticotropic Hormone, 9002-60-2; beta-Endorphin, 60617-12-1; Corticosterone, 50-22-6; Cytokines; Interleukin-2; Interleukin-6; Lipopolysaccharides; RNA, Messenger; Tumor Necrosis Factor-alpha | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JNRID | ||
| 100 | 1 | |a Refojo, D. | |
| 245 | 1 | 0 | |a Increased splenocyte proliferative response and cytokine production in β-endorphin-deficient mice |
| 260 | |c 2002 | ||
| 270 | 1 | 0 | |m Arzt, E.; Departamento de Biología, Universidad de Buenos Aires, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina; email: earzt@fbmc.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a We used β-endorphin-deficient mice as a novel approach to confirm the physiological role that opioid peptides play in the development or regulation of the immune system. We found that mice lacking β-endorphin possessed an enhanced immune response, measured in terms of splenocyte proliferation and interleukin (IL)-2 mRNA levels, in vitro production of the splenic macrophage inflammatory cytokines IL-6 and Tumor Necrosis Factor (TNF)-α and plasma IL-6 following lipopolysaccharide (LPS) administration. β-Endorphin-deficient mice had attenuated increases of plasma ACTH and corticosterone levels in response to LPS. These results are consistent with a postulated inhibitory role of endogenous β-endorphin on the immune system at multiple levels. © 2002 Elsevier Science B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: P01 DK55819 | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: National Council for Scientific Research | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work was supported by grants from the Argentine National Research Council (CONICET), the University of Buenos Aires, Agencia Nacional de Promoción Cientı́fica y Tecnológica-Argentina, and the National Institutes of Health P01 DK55819 (to M.J. Low). | ||
| 593 | |a Laboratorio de Fisiología y Biología Molecular, Departamento de Biología, Facultad de Ciencias Exactas y Naturales (FCEN), Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II, C1428EHA Buenos Aires, Argentina | ||
| 593 | |a INGEBI-CONICET, Buenos Aires, Argentina | ||
| 593 | |a Max-Planck Institute of Psychiatry, Kraepelin str. 10, 80804 Munich, Germany | ||
| 593 | |a Vollum Institute, Oregon Health and Science University, Portland, OR, United States | ||
| 690 | 1 | 0 | |a Β-ENDORPHIN |
| 690 | 1 | 0 | |a CYTOKINES |
| 690 | 1 | 0 | |a HPA AXIS |
| 690 | 1 | 0 | |a NEUROIMMUNOLOGY |
| 690 | 1 | 0 | |a SPLENOCYTE |
| 690 | 1 | 0 | |a BETA ENDORPHIN |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a CORTICOTROPIN |
| 690 | 1 | 0 | |a INTERLEUKIN 12 |
| 690 | 1 | 0 | |a INTERLEUKIN 6 |
| 690 | 1 | 0 | |a LIPOPOLYSACCHARIDE |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a TUMOR NECROSIS FACTOR ALPHA |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CORTICOSTERONE BLOOD LEVEL |
| 690 | 1 | 0 | |a CORTICOTROPIN BLOOD LEVEL |
| 690 | 1 | 0 | |a CYTOKINE PRODUCTION |
| 690 | 1 | 0 | |a IMMUNE RESPONSE |
| 690 | 1 | 0 | |a IMMUNE SYSTEM |
| 690 | 1 | 0 | |a IMMUNOREGULATION |
| 690 | 1 | 0 | |a MACROPHAGE |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN BLOOD LEVEL |
| 690 | 1 | 0 | |a PROTEIN DEFICIENCY |
| 690 | 1 | 0 | |a SPLEEN CELL |
| 690 | 1 | 0 | |a ADRENOCORTICOTROPIC HORMONE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BETA-ENDORPHIN |
| 690 | 1 | 0 | |a CELL DIVISION |
| 690 | 1 | 0 | |a CELLS, CULTURED |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a CYTOKINES |
| 690 | 1 | 0 | |a INTERLEUKIN-2 |
| 690 | 1 | 0 | |a INTERLEUKIN-6 |
| 690 | 1 | 0 | |a LIPOPOLYSACCHARIDES |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED C57BL |
| 690 | 1 | 0 | |a MICE, KNOCKOUT |
| 690 | 1 | 0 | |a RNA, MESSENGER |
| 690 | 1 | 0 | |a SPLEEN |
| 690 | 1 | 0 | |a TUMOR NECROSIS FACTOR-ALPHA |
| 700 | 1 | |a Kovalovsky, D. | |
| 700 | 1 | |a Young, J.I. | |
| 700 | 1 | |a Rubinstein, M. | |
| 700 | 1 | |a Holsboer, F. | |
| 700 | 1 | |a Reul, J.M.H.M | |
| 700 | 1 | |a Low, M.J. | |
| 700 | 1 | |a Arzt, E. | |
| 773 | 0 | |d 2002 |g v. 131 |h pp. 126-134 |k n. 1-2 |p J. Neuroimmunol. |x 01655728 |w (AR-BaUEN)CENRE-5708 |t Journal of Neuroimmunology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/S0165-5728(02)00268-0 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_01655728_v131_n1-2_p126_Refojo |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01655728_v131_n1-2_p126_Refojo |y Registro en la Biblioteca Digital |
| 961 | |a paper_01655728_v131_n1-2_p126_Refojo |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 66163 | ||