Towards a classification of glycosyltransferases based on amino acid sequence similarities: Prokaryotic α-mannosyltransferases

A number of genes encoding bacterial glycosyltransferases have been sequenced during the last few years, but their low sequence similarity has prevented a straightforward grouping of these enzymes into families. The sequences of several bacterial α-mannosyltransferases have been compared using curre...

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Autor principal: Geremia, R.A
Otros Autores: Petroni, E.A, Ielpi, L., Henrissat, B.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Portland Press Ltd 1996
Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
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024 7 |2 Molecular Sequence Numbers  |a GENBANK: U37258; 
024 7 |2 cas  |a glycosyltransferase, 9033-07-2; mannosyltransferase, 9055-06-5 
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100 1 |a Geremia, R.A. 
245 1 0 |a Towards a classification of glycosyltransferases based on amino acid sequence similarities: Prokaryotic α-mannosyltransferases 
260 |b Portland Press Ltd  |c 1996 
270 1 0 |m Henrissat, B.; Ctr Recherches Macromolec Vegetales, Univ Joseph Fourier, CNRS, BP 53, 38041 Grenoble cedex 9, France 
506 |2 openaire  |e Política editorial 
504 |a Saxena, I.M., Brown, R.M.J., Fèvre, M., Geremia, R.A., Henrissat, B., (1995) J. Bacteriol., 177, pp. 1419-1424 
504 |a Sinnott, M.L., (1991) Chem. Rev., 90, pp. 1171-1202 
504 |a Henrissat, B., (1991) Biochem. J., 280, pp. 309-316 
504 |a Henrissat, B., Bairoch, A., (1993) Biochem. J., 293, pp. 781-788 
504 |a Davies, G., Henrissat, B., (1995) Structure, 3, pp. 853-859 
504 |a Gebler, J., Gilkes, N.R., Claeyssens, M., Wilson, D.B., Béguin, P., Wakarchuk, W.W., Kilburn, D.G., Withers, S.G., (1992) J. Biol. Chem., 267, pp. 12559-12561 
504 |a Paulson, J.C., Colley, K.J., (1989) J. Biol. Chem., 264, pp. 17615-17618 
504 |a Joziasse, D.H., (1992) Glycobiology, 2, pp. 271-277 
504 |a Gaboriaud, C., Bissery, V., Benchetrit, T., Mornon, J.P., (1987) FEBS Lett., 224, pp. 149-155 
504 |a Lemesle-Varloot, L., Henrissat, B., Gaboriaud, C., Bissery, V., Morgat, A., Mornon, J.P., (1990) Biochimie, 72, pp. 555-574 
504 |a Henrissat, B., Callebaut, I., Fabrega, S., Lehn, P., Mornon, J.P., Davies, G., (1995) Proc. Natl. Acad. Sci. U.S.A., 92, pp. 7090-7094 
504 |a Whitfield, C., Valvano, M.A., (1993) Adv. Microb. Physiol., 35, pp. 135-246 
504 |a Liu, D., Haase, A.M., Lindqvist, L., Lindenberg, A.A., Reeves, P.R., (1993) J. Bacteriol., 175, pp. 3408-3413 
504 |a Kido, N., Torgov, V.I., Sugiyama, T., Uchiya, K., Sugihara, H., Komatsu, T., Kato, N., Jann, K., (1995) J. Bacteriol., 177, pp. 2178-2187 
504 |a Capage, M.A., Doherty, D.H., Betlach, M.R., Vanderslice, R.W., (1987), Patent, International Publication Number WO 87/05938; Petroni, E.A., Ielpi, L., (1996) J. Bacteriol., , in the press 
504 |a Woodcock, S., Mornon, J.-P., Henrissat, B., (1992) Protein Eng., 5, pp. 629-635 
504 |a Lee, S.J., Romana, L.K., Reeves, P.R., (1992) J. Gen. Microbiol., 138, pp. 1843-1855 
504 |a Miyata, T., Takeda, J., Iida, Y., Yamada, N., Inoue, N., Takahashi, M., Maeda, K., Kinoshita, T., (1993) Science, 259, pp. 1318-1320 
504 |a Schonbachler, M., Horvath, A., Fassler, J., Riezma, H., (1995) EMBO J., 14, pp. 1637-1645 
504 |a Altschul, S.F., Gish, W., Miller, W., Myers, E.W., Lipman, D.J., (1990) J. Mol. Biol., 215, pp. 403-410 
520 3 |a A number of genes encoding bacterial glycosyltransferases have been sequenced during the last few years, but their low sequence similarity has prevented a straightforward grouping of these enzymes into families. The sequences of several bacterial α-mannosyltransferases have been compared using current alignment algorithms as well as hydrophobic cluster analysis (HCA). These sequences show a similarity which is significant but too low to be reliably aligned using automatic alignment methods. However, a region spanning approx. 270 residues in these proteins could be aligned by HCA, and several invariant amino acid residues were identified. These features were also found in several other glycosyltransferases, as well as in proteins of unknown function present in sequence databases. This similarity most probably reflects the existence of a family of proteins with conserved structural and mechanistic features. It is argued that the present IUBMB classification of glycosyltransferases could be complemented by a classification of these enzymes based on sequence similarities analogous to that which we proposed for glycosyl hydrolases.  |l eng 
593 |a Centre de Recherches sur les Macromolécules Végétales, Université Joseph Fourier, C.N.R.S., BP 53, 38041 Grenoble Cedex 9, France 
593 |a Instituto de Investigaciones Bioquimicas 'Fundacion Campomar', Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Patricias Argentinas 435, (1405) Buenos Aires, Argentina 
690 1 0 |a GLYCOSYLTRANSFERASE 
690 1 0 |a MANNOSYLTRANSFERASE 
690 1 0 |a ALGORITHM 
690 1 0 |a AMINO ACID SEQUENCE 
690 1 0 |a ARTICLE 
690 1 0 |a CLUSTER ANALYSIS 
690 1 0 |a DATA BASE 
690 1 0 |a GENE SEQUENCE 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN FAMILY 
690 1 0 |a BACTERIA (MICROORGANISMS) 
690 1 0 |a PROKARYOTA 
700 1 |a Petroni, E.A. 
700 1 |a Ielpi, L. 
700 1 |a Henrissat, B. 
773 0 |d Portland Press Ltd, 1996  |g v. 318  |h pp. 133-138  |k n. 1  |p BIOCHEM. J.  |x 02646021  |w (AR-BaUEN)CENRE-205  |t Biochemical Journal 
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