β-carboline alkaloids as matrices for UV-matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in positive and negative ion modes. Analysis of proteins of high molecular mass, and of cyclic and acyclic oligosaccharides

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We report that commercially available β-carbolines (nor-harmane (9H-pyrido[3,4-b]indole), harmane (1-methyl-9H-pyrido[3,4-b]indole), harmine (7-methoxy-1-methyl-9H-pyrido[3,4-b]indole), harmol (1-methyl-9H-pyrido[3,4-b]indol-7-d]), harmaline (3,4-dihydro-7-methoxy-1-methyl-9H-pyrido[3,4-b]indole) an...

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Detalles Bibliográficos
Autor principal: Nonami, H.
Otros Autores: Tanaka, K., Fukuyama, Y., Erra-Balsells, R.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1998
Materias:
LASER
Acceso en línea:Registro en Scopus
DOI
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-0031887937 
024 7 |2 cas  |a Carbolines; Oligosaccharides; Proteins 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a RCMSE 
100 1 |a Nonami, H. 
245 1 0 |a β-carboline alkaloids as matrices for UV-matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in positive and negative ion modes. Analysis of proteins of high molecular mass, and of cyclic and acyclic oligosaccharides 
260 |c 1998 
270 1 0 |m Erra-Balsells, R.; Departamento de Quimica Organica, Facultad Ciencias Exactas/Naturales, Universidad de Buenos Aires, c.c. 74 - Suc. 30, 1430 Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Vertes, A., Gijbels, R., Adams, F., (1993) Laser Ionization Mass Analysis, , Wiley, New York 
504 |a Schlag, E.W., (1994) Time-of-Flight Mass Spectrometry and Its Applications, , Elsevier, New York 
504 |a Gross, M.L., Mass Spectrometry in Biological Sciences: A Tutorial (1990) NATO ASI Series, 353. , Kluwer, London 
504 |a Danis, P.O., Karr, D.E., (1993) Org. Mass Spectrom., 28, p. 923 
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504 |a Zhang, H., Caprioli, R.M., (1996) J. Mass Spectrom., 31, p. 1039 
504 |a Amado, F.M.L., Santana-Marques, M.G., Ferrer-Correia, A.J., Tomer, K.B., (1967) Anal. Chem., 69, p. 1102 
504 |a Tsarbopoulos, A., Pramanik, B.N., Karas, M., Bahr, U., Zeng-Stahl, J.-R., (1995) J. Mass Spectrom., Rapid Commun. Mass Spectrom., 31, pp. S207-S209 
504 |a Zhang, H., Caprioli, R.M., (1996) J. Mass Spectrom., 31, p. 690 
504 |a Karas, M., Ehring, H., Nordhoff, E., Stahl, B., Strupat, K., Hillenkamp, F., Grehl, M., Krebs, B., (1993) Org. Mass Spectrom., 28, p. 1476 
504 |a Mohr, M.D., Bornsen, K.O., Widmer, H.M., (1995) Rapid Commun. Mass Spectrom., 9, p. 809 
504 |a Xu, N., Huang, Z.-H., Watson, J.T., Gage, D.A., (1997) J. Am. Soc. Mass Spectrom., 8, p. 116 
504 |a Nonami, H., Fukui, S., Erra-Balsells, R., (1997) J. Mass Spectrom., 32, p. 287 
504 |a Haisa, M., Kashino, S., Hanada, S.I., Tanaka, K., Okazaki, S., Shibagaki, M., (1983) Acta Crystallogr., Sect. B, 38, p. 1480 
504 |a Beavis, R.C., Bridson, J.N., (1993) J. Phys. D, 26, p. 442 
504 |a Dreisewerd, K., Schurenberg, M., Karas, M., Hillenkamp, F., (1995) Int. J. Mass Spectrom. Ion Processes, 141, p. 127 
504 |a Xiang, F., Beavis, R.C., (1994) Rapid Commun. Mass Spectrom., 8, p. 199 
504 |a (1976) The Merck Index, 9th Edition 
504 |a (1996) Aldrich Catalog Handbook of Fine Chemicals 
504 |a Biondic, M.C., Erra-Balsells, R., (1992) J. Chem. Soc., Perkin Trans. 2, p. 1049 
504 |a Biondic, M.C., Erra-Balsells, R., (1993) J. Chem. Soc., Perkin Trans. 2, p. 887 
504 |a Biondic, M.C., (1996), Thesis, Universidad de Buenos Aires; Tomas Vert, F., Zabala Sanchez, I., Olba Torrent, A., (1983) J. Photochem., 23, p. 35 
504 |a Tomas Vert, F., Zabala Sanchez, I., Olba Torrent, A., (1984) J. Photochem., 26, p. 285 
504 |a Tomas, F., Zabala, I., Olba, A., (1985) J. Photochem., 31, p. 253 
504 |a Biondic, M.C., Erra-Balsells, R., (1997) J. Chem. Soc., Perkin Trans 2, p. 1323 
504 |a Nonami, H., Wu, F., Thummel, R.P., Erra-Balsells, R., Pyridoindoles As MALDI UV TOF-MS Matrix, (1 PART). , unpublished results 
504 |a Nonami, H., Erra-Balsells, R., Pyridoindoles As MALDI UV TOF-MS Matrix, (2 PART) 
520 3 |a We report that commercially available β-carbolines (nor-harmane (9H-pyrido[3,4-b]indole), harmane (1-methyl-9H-pyrido[3,4-b]indole), harmine (7-methoxy-1-methyl-9H-pyrido[3,4-b]indole), harmol (1-methyl-9H-pyrido[3,4-b]indol-7-d]), harmaline (3,4-dihydro-7-methoxy-1-methyl-9H-pyrido[3,4-b]indole) and harmalol (3-4-dihydro-1-methyl-9H-pyrido[3,4-b]indol-7-ol)), are useful MALDI matrices at 337 nm, for cyclic oligosaccharides (cyclodextrins, range 972-1290 Da), acyclic oligosaccharides (range 342-828 Da) and high molecular mass proteins (range 23 290-66 525 Da) in both positive and negative modes. This was investigated by using time-of-flight (TOF) mass spectrometers of different sensitivities, equipped with and without pulse extraction facilities. A comparison with conventional matrices for carbohydrates (DHB and DHB/HIC) indicates that β-carbolines provide the same level of sensitivity and resolution in the positive mode, but offer the advantage of high levels of sensitivity and resolution in the negative mode. Harmaline has been found to be specially effective for the analysis of high-mass proteins in both modes, and also exhibits excellent experimental reproducibility of the results owing to the homogeneous crystallization of the analyte-matrix mixture over the entire sample surface area. Harmane and nor-harmane are both excellent matrices for high-mass proteins also. As MALDI matrices, β-carbolines permit measurement of sulfated sugars in the negative ion mode as ([M-H]), and of neutral sugars and proteins as both [M+U]+ and [M-H]- in appropriate modes.  |l eng 
593 |a Plant Biophys./Biochem. Res. Lab., College of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama 790, Japan 
593 |a Shimadzu Res. Lab. Ltd. Wharfside, Trafford Wharf Road, Manchester M17 1GP, United Kingdom 
593 |a Depto. de Quim. Orgánica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, c.c. 74 - Suc. 30, 1430 Buenos Aires, Argentina 
690 1 0 |a CARBOLINE DERIVATIVE 
690 1 0 |a OLIGOSACCHARIDE 
690 1 0 |a PROTEIN 
690 1 0 |a ARTICLE 
690 1 0 |a CHEMISTRY 
690 1 0 |a MASS SPECTROMETRY 
690 1 0 |a MOLECULAR WEIGHT 
690 1 0 |a ULTRAVIOLET RADIATION 
690 1 0 |a CARBOLINES 
690 1 0 |a LASERS 
690 1 0 |a MOLECULAR WEIGHT 
690 1 0 |a OLIGOSACCHARIDES 
690 1 0 |a PROTEINS 
690 1 0 |a SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION 
690 1 0 |a ULTRAVIOLET RAYS 
650 1 7 |2 spines  |a LASER 
700 1 |a Tanaka, K. 
700 1 |a Fukuyama, Y. 
700 1 |a Erra-Balsells, R. 
773 0 |d 1998  |g v. 12  |h pp. 285-296  |k n. 6  |p Rapid Commun. Mass Spectrom.  |x 09514198  |t Rapid Communications in Mass Spectrometry 
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856 4 0 |u https://doi.org/10.1002/(SICI)1097-0231(19980331)12:6<285::AID-RCM158>3.0.CO;2-4  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_09514198_v12_n6_p285_Nonami  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09514198_v12_n6_p285_Nonami  |y Registro en la Biblioteca Digital 
961 |a paper_09514198_v12_n6_p285_Nonami  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 

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