Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins
Purpose: Several mechanisms have been proposed to explain the fibrin- platelet thrombosis at the microcirculation level in the different clinical conditions of hemolytic uremic syndrome (HUS). The relationships between platelet structure and function during the first 4 weeks of evolution of the dise...
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| Otros Autores: | , , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1999
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 12087caa a22015017a 4500 | ||
|---|---|---|---|
| 001 | PAPER-2672 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203208.0 | ||
| 008 | 190411s1999 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0343091353 | |
| 024 | 7 | |2 cas |a Bacterial Toxins; Blood Coagulation Factors; Blood Proteins; globotriaosylceramide, 71965-57-6; Platelet Membrane Glycoproteins; Shiga-Like Toxin I; Trihexosylceramides | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JPHOF | ||
| 100 | 1 | |a Sassetti, B. | |
| 245 | 1 | 0 | |a Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins |
| 260 | |c 1999 | ||
| 270 | 1 | 0 | |m Sassetti, B.; Departamento Quimica Biologica, Fac. de Ciencias Exactas/Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428-Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Marta, R., Florentini, L., Diaz, M., Increased thrombin generation markers and TNF levels in children with epidemic thrombotic microangiopathy (1998) Medicina, 58, pp. 8-12 | ||
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| 504 | |a Nevard, C., Jurd, K., Lane, D., Activation of coagulation and fibrinolysis in childhood diarrhoea-associated haemolytic uraemic syndrome (1997) Thromb Haemost, 78, pp. 1450-1455 | ||
| 504 | |a Turi, S., Nemeth, I., Vargha, I., Oxidative damage of red blood cells in haemolytic uraemic syndrome (1994) Pediatr Nephrol, 8, pp. 26-29 | ||
| 504 | |a Facorro, G., Aguirre, F., Florentini, L., Oxidative stress and membrane fluidity in erythrocytes from patients with hemolytic uremic syndrome (1997) Acta Physiol Pharmacol Ther Latinoam, 47, pp. 137-146 | ||
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| 504 | |a Sreedhara, R., Itagaki, I., Hakim, R.M., Uremic patients have decreased shear-induced platelet aggregation mediated by decreased availability of glycoprotein IIbIIIa receptors (1996) Am J Kidney Dis, 27, pp. 355-364 | ||
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| 520 | 3 | |a Purpose: Several mechanisms have been proposed to explain the fibrin- platelet thrombosis at the microcirculation level in the different clinical conditions of hemolytic uremic syndrome (HUS). The relationships between platelet structure and function during the first 4 weeks of evolution of the disease were studied to understand the mechanism of platelet alteration. Patients and Methods: Coagulation parameters, platelet counts, and aggregation were studied in 49 children, and membrane glycoproteins (GPs) in 20 of the 49 children (mean age, 17 months) with HUS (Group 2) were studied during the first 4 weeks of evolution of the disease. Results: No disseminated intravascular coagulation was found in patients with recurrent or persistent thrombocytopenia. Platelet aggregation was sequentially performed during the first weeks of evolution. All patients had a functional decrease in the acute period of HUS. Platelet GPs GPIb, GPIIbIIIa, GPIIb, and GPIIIa were evaluated. GPIIbIIIa complex presented low level and never reached normal values during the first 4 weeks of disease. Conclusions: Platelet alterations are probably caused by multiple mechanisms: 'exhausted' platelets, structural membrane alterations caused by arginine-glycine- aspartic peptide blockade, or diminished or nonfunctional membrane GPIb and GPIIbIIIa complexes. |l eng | |
| 593 | |a Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Hemostasia, Argentina | ||
| 593 | |a Hospital Privado Güemes, Hemostasia, Argentina | ||
| 593 | |a Hospital J.P. Garrahan, Nefrología, Argentina | ||
| 593 | |a Hosp. de Clinicas, J. de S. Martin, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II 4 P, 1428-Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CHILDREN |
| 690 | 1 | 0 | |a GLYCOPROTEINS |
| 690 | 1 | 0 | |a GPIIBIIIA |
| 690 | 1 | 0 | |a HUS |
| 690 | 1 | 0 | |a PLATELETS |
| 690 | 1 | 0 | |a UREMIC HEMOLYTIC SYNDROME |
| 690 | 1 | 0 | |a FIBRINOGEN RECEPTOR |
| 690 | 1 | 0 | |a GLYCOPROTEIN |
| 690 | 1 | 0 | |a GLYCOPROTEIN IB |
| 690 | 1 | 0 | |a GLYCOPROTEIN IIB |
| 690 | 1 | 0 | |a MEMBRANE PROTEIN |
| 690 | 1 | 0 | |a VERY LATE ACTIVATION ANTIGEN 2 |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CLINICAL ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HEMOLYTIC UREMIC SYNDROME |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a HUMAN TISSUE |
| 690 | 1 | 0 | |a INFANT |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOLECULAR DYNAMICS |
| 690 | 1 | 0 | |a PATHOPHYSIOLOGY |
| 690 | 1 | 0 | |a PRESCHOOL CHILD |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a STRUCTURE ACTIVITY RELATION |
| 690 | 1 | 0 | |a THROMBOCYTE AGGREGATION |
| 690 | 1 | 0 | |a THROMBOCYTE COUNT |
| 690 | 1 | 0 | |a BACTERIAL TOXINS |
| 690 | 1 | 0 | |a BLOOD COAGULATION FACTORS |
| 690 | 1 | 0 | |a BLOOD PROTEINS |
| 690 | 1 | 0 | |a CHILD, PRESCHOOL |
| 690 | 1 | 0 | |a DIARRHEA, INFANTILE |
| 690 | 1 | 0 | |a DYSENTERY, BACILLARY |
| 690 | 1 | 0 | |a ENDOTHELIUM, VASCULAR |
| 690 | 1 | 0 | |a ESCHERICHIA COLI INFECTIONS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HEMOLYTIC-UREMIC SYNDROME |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a INFANT |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICROCIRCULATION |
| 690 | 1 | 0 | |a PLATELET AGGREGATION |
| 690 | 1 | 0 | |a PLATELET COUNT |
| 690 | 1 | 0 | |a PLATELET MEMBRANE GLYCOPROTEINS |
| 690 | 1 | 0 | |a SHIGA-LIKE TOXIN I |
| 690 | 1 | 0 | |a SPLEEN |
| 690 | 1 | 0 | |a THROMBOPHILIA |
| 690 | 1 | 0 | |a TRIHEXOSYLCERAMIDES |
| 700 | 1 | |a Vizcargüénaga, M.I. | |
| 700 | 1 | |a Zanaro, N.L. | |
| 700 | 1 | |a Silva, M.V. | |
| 700 | 1 | |a Kordich, L. | |
| 700 | 1 | |a Florentini, L. | |
| 700 | 1 | |a Diaz, M. | |
| 700 | 1 | |a Vitacco, M. | |
| 700 | 1 | |a Sanchez Avalos, J.C. | |
| 773 | 0 | |d 1999 |g v. 21 |h pp. 123-128 |k n. 2 |p J. Pediatr. Hematol. Oncol. |x 10774114 |t Journal of Pediatric Hematology/Oncology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1097/00043426-199903000-00008 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_10774114_v21_n2_p123_Sassetti |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10774114_v21_n2_p123_Sassetti |y Registro en la Biblioteca Digital |
| 961 | |a paper_10774114_v21_n2_p123_Sassetti |b paper |c PE | ||
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