Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels.

This chapter discusses cocaine-mediated actions on thalamic networks gamma-aminobutyric acid (GABA) transmission. Cocaine effects are associated with catecholamine reuptake inhibitions but local anesthetic mechanisms have been described. We focused our attention on the cocaine effects on thalamic re...

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Autor principal: Urbano, F.J
Otros Autores: Bisagno, V.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Elsevier Inc. 2017
Acceso en línea:Registro en Scopus
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100 1 |a Urbano, F.J. 
245 1 0 |a Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels. 
260 |b Elsevier Inc.  |c 2017 
270 1 0 |m Urbano, F.J.; Instituto de Fisiología, Biología Molecular y neurociencias (IFIBYNE, CONICET-UBA), Universidad de Buenos AiresArgentina 
506 |2 openaire  |e Política editorial 
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520 3 |a This chapter discusses cocaine-mediated actions on thalamic networks gamma-aminobutyric acid (GABA) transmission. Cocaine effects are associated with catecholamine reuptake inhibitions but local anesthetic mechanisms have been described. We focused our attention on the cocaine effects on thalamic reticular nucleus, the main GABAergic afferents to sensory thalamic nuclei in rodents. Although cocaine can inhibit GABA release throughout the upregulation of presyanptic inhibitory serotonin (5-HT) 5-HT1A-typereceptors, local anesthetic-like effects of cocaine on thalamic reticular neurons can also contribute to the long-term thalamocortical alteration by this psychostimulant. Cocaine-mediated disruption of GABA neurotransmission might underlie aberrant thalamocortical physiology described in humans after repetitive cocaine use. © 2017 Elsevier Inc. All rights reserved.  |l eng 
593 |a Instituto de Fisiología, Biología Molecular y neurociencias (IFIBYNE, CONICET-UBA), Universidad de Buenos Aires, Argentina 
593 |a Instituto de Investigaciones Farmacológicas (ININFA, CONICET-UBA), Universidad de Buenos Aires, Argentina 
690 1 0 |a COCAINE 
690 1 0 |a GABAA RECEPTORS 
690 1 0 |a SEROTONIN RECEPTORS 
690 1 0 |a THALAMIC RETICULAR NUCLEUS 
690 1 0 |a THALAMOCORTICAL 
700 1 |a Bisagno, V. 
773 0 |d Elsevier Inc., 2017  |h pp. 511-518  |p The Neurosci. of Cocaine: Mech. and Treat.  |z 9780128037928  |z 9780128037508  |t The Neuroscience of Cocaine: Mechanisms and Treatment 
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