Elevated cyclic AMP inhibits mycobacterium tuberculosis-stimulated T-cell IFN-γ secretion through type I protein kinase A
Cyclic adenosine monophosphate (cAMP) is critical in immune regulation, and its role in tuberculosis infection remains unclear. We determined the levels of cAMP in peripheral blood mononuclear cells (PBMC) from tuberculosis patients and the mechanisms for cAMP suppression of IFN-γ production. PBMC f...
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| Otros Autores: | , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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Oxford University Press
2018
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 16720caa a22014777a 4500 | ||
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| 001 | PAPER-25201 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205713.0 | ||
| 008 | 190410s2018 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85052016062 | |
| 024 | 7 | |2 cas |a cyclic AMP, 60-92-4; cyclic AMP responsive element binding protein, 130428-87-4, 130939-96-7; gamma interferon, 82115-62-6; interleukin 12, 138415-13-1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JIDIA | ||
| 100 | 1 | |a Chung, Y.-T. | |
| 245 | 1 | 0 | |a Elevated cyclic AMP inhibits mycobacterium tuberculosis-stimulated T-cell IFN-γ secretion through type I protein kinase A |
| 260 | |b Oxford University Press |c 2018 | ||
| 270 | 1 | 0 | |m Samten, B.; Department of Pulmonary Immunology, University of Texas Health Science Center, 11937 US Hwy 271, United States; email: buka.samten@uthct.edu |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Cyclic adenosine monophosphate (cAMP) is critical in immune regulation, and its role in tuberculosis infection remains unclear. We determined the levels of cAMP in peripheral blood mononuclear cells (PBMC) from tuberculosis patients and the mechanisms for cAMP suppression of IFN-γ production. PBMC from tuberculosis patients contained significantly elevated cAMP than latent tuberculosis infected subjects (LTBI), with an inverse correlation with IFN-γ production. Consistent with this, the expression of cAMP response element binding protein (CREB), activating transcription factor (ATF)-2 and c-Jun were reduced in tuberculosis patients compared with LTBI. PKA type I specific cAMP analogs inhibited Mtb-stimulated IFN-g production by PBMC through suppression of Mtb-induced IFN-γ promoter binding activities of CREB, ATF-2, and c-Jun and also miR155, the target miRNA of these transcription factors. Neutralizing both IL-10 and TGF-β1 or supplementation of IL-12 restored cAMP-suppressed IFN-g production. We conclude that increased cAMP inhibits IFN-g production through PKA type I pathway in tuberculosis infection. © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Texas A and M University Health Science Center | ||
| 536 | |a Detalles de la financiación: Universidad Nacional del Centro de la Provincia de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Facultad de Ciencias Físicas y Matemáticas | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Texas A and M University Health Science Center | ||
| 536 | |a Detalles de la financiación: National Institutes of Health, 1R56AI116864 | ||
| 536 | |a Detalles de la financiación: 1Department of Pulmonary Immunology, University of Texas Health Science Center, Tyler; 2Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires, Universidad Nacional del Noroeste de la Provincia de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas, Junín, Argentina; and 3Departamento de Química Biológica, and Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina | ||
| 536 | |a Detalles de la financiación: Financial support. This work was supported in part by the funds from the National Institutes of Health (grant number 1R56AI116864) and the University of Texas Health Science Center at Tyler, Texas. | ||
| 593 | |a Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires, Universidad Nacional del Noroeste de la Provincia de Buenos Aires- Consejo Nacional de Investigaciones Científicas y Técnicas, Junín, Argentina | ||
| 593 | |a Departamento de Química Biológica, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina | ||
| 593 | |a Department of Vet Biomedical Sciences, Oregon State University, United States | ||
| 593 | |a Department of Pulmonary Immunology, University of Texas Health Science Center, 11937 US Hwy 271, Tyler, TX 75708-3154, United States | ||
| 690 | 1 | 0 | |a CYCLIC ADENOSINE MONOPHOSPHATE |
| 690 | 1 | 0 | |a CYTOKINE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a TRANSCRIPTION FACTOR |
| 690 | 1 | 0 | |a ACTIVATING TRANSCRIPTION FACTOR 2 |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a CYCLIC AMP DEPENDENT PROTEIN KINASE 1 |
| 690 | 1 | 0 | |a CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN |
| 690 | 1 | 0 | |a GAMMA INTERFERON |
| 690 | 1 | 0 | |a INTERLEUKIN 10 |
| 690 | 1 | 0 | |a INTERLEUKIN 12 |
| 690 | 1 | 0 | |a MICRORNA 155 |
| 690 | 1 | 0 | |a PROTEIN C JUN |
| 690 | 1 | 0 | |a TRANSFORMING GROWTH FACTOR BETA1 |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOKINE PRODUCTION |
| 690 | 1 | 0 | |a CYTOKINE RELEASE |
| 690 | 1 | 0 | |a GEL MOBILITY SHIFT ASSAY |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a LATENT TUBERCULOSIS |
| 690 | 1 | 0 | |a LUNG TUBERCULOSIS |
| 690 | 1 | 0 | |a MAJOR CLINICAL STUDY |
| 690 | 1 | 0 | |a MYCOBACTERIUM TUBERCULOSIS |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PERIPHERAL BLOOD MONONUCLEAR CELL |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a WESTERN BLOTTING |
| 650 | 1 | 7 | |2 spines |a TUBERCULOSIS |
| 700 | 1 | |a Pasquinelli, V. | |
| 700 | 1 | |a Jurado, J.O. | |
| 700 | 1 | |a Wang, X. | |
| 700 | 1 | |a Yi, N. | |
| 700 | 1 | |a Barnes, P.F. | |
| 700 | 1 | |a Garcia, V.E. | |
| 700 | 1 | |a Samten, B. | |
| 773 | 0 | |d Oxford University Press, 2018 |g v. 217 |h pp. 1821-1831 |k n. 11 |p J. Infect. Dis. |x 00221899 |w (AR-BaUEN)CENRE-5621 |t Journal of Infectious Diseases | |
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