Regulation of alternative splicing through coupling with transcription and chromatin structure

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Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific f...

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Autor principal: Naftelberg, S.
Otros Autores: Schor, I.E, Ast, G., Kornblihtt, A.R
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Annual Reviews Inc. 2015
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-84930716439 
024 7 |2 cas  |a histone, 9062-68-4; Chromatin; Histones; Nucleosomes 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a ARBOA 
100 1 |a Naftelberg, S. 
245 1 0 |a Regulation of alternative splicing through coupling with transcription and chromatin structure 
260 |b Annual Reviews Inc.  |c 2015 
270 1 0 |m Ast, G.; Sackler Medical School, Tel Aviv UniversityIsrael 
506 |2 openaire  |e Política editorial 
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520 3 |a Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific features, normal cell functioning, and responses of eukaryotic cells to external cues. Its importance is confirmed by the evolutionary conservation and diversification of alternative splicing and the fact that its deregulation causes hereditary disease and cancer. This review discusses the multiple layers of cotranscriptional regulation of alternative splicing in which chromatin structure, DNA methylation, histone marks, and nucleosome positioning play a fundamental role in providing a dynamic scaffold for interactions between the splicing and transcription machineries. We focus on evidence for how the kinetics of RNA polymerase II (RNAPII) elongation and the recruitment of splicing factors and adaptor proteins to chromatin components act in coordination to regulate alternative splicing. Copyright © 2015 by Annual Reviews. All rights reserved.  |l eng 
536 |a Detalles de la financiación: Israel Science Foundation, ISF, 142/13 
536 |a Detalles de la financiación: Israel Cancer Association, ICA, 20140091 
536 |a Detalles de la financiación: Israel Science Foundation, ISF, 757/12 
593 |a Sackler Medical School, Tel Aviv University, Tel Aviv, 69978, Israel 
593 |a Instituto de Fisiología, Biología Molecular y Neurociencias, Departamento de Fisiología, Biología Molecular y Celular, Ciudad Universitaria, Buenos Aires, C1428EHA, Argentina 
690 1 0 |a ALTERNATIVE SPLICING 
690 1 0 |a CHROMATIN ORGANIZATION 
690 1 0 |a HISTONE MODIFICATIONS 
690 1 0 |a MOLECULAR EVOLUTION 
690 1 0 |a NUCLEOSOME POSITIONING 
690 1 0 |a TRANSCRIPTION 
690 1 0 |a ADAPTOR PROTEIN 
690 1 0 |a HISTONE 
690 1 0 |a RNA POLYMERASE II 
690 1 0 |a CHROMATIN 
690 1 0 |a NUCLEOSOME 
690 1 0 |a ALTERNATIVE RNA SPLICING 
690 1 0 |a CHROMATIN STRUCTURE 
690 1 0 |a DENSITY 
690 1 0 |a DNA METHYLATION 
690 1 0 |a HISTONE MODIFICATION 
690 1 0 |a HUMAN 
690 1 0 |a KINETICS 
690 1 0 |a MACHINE 
690 1 0 |a NONHUMAN 
690 1 0 |a NUCLEOSOME 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a REVIEW 
690 1 0 |a ANIMAL 
690 1 0 |a BIOLOGICAL MODEL 
690 1 0 |a CHROMATIN 
690 1 0 |a GENE EXPRESSION REGULATION 
690 1 0 |a GENETIC TRANSCRIPTION 
690 1 0 |a METABOLISM 
690 1 0 |a PROTEIN PROCESSING 
690 1 0 |a EUKARYOTA 
690 1 0 |a ALTERNATIVE SPLICING 
690 1 0 |a ANIMALS 
690 1 0 |a CHROMATIN 
690 1 0 |a DNA METHYLATION 
690 1 0 |a GENE EXPRESSION REGULATION 
690 1 0 |a HISTONES 
690 1 0 |a HUMANS 
690 1 0 |a MODELS, GENETIC 
690 1 0 |a NUCLEOSOMES 
690 1 0 |a PROTEIN PROCESSING, POST-TRANSLATIONAL 
690 1 0 |a TRANSCRIPTION, GENETIC 
700 1 |a Schor, I.E. 
700 1 |a Ast, G. 
700 1 |a Kornblihtt, A.R. 
773 0 |d Annual Reviews Inc., 2015  |g v. 84  |h pp. 165-198  |p Annu. Rev. Biochem.  |x 00664154  |w (AR-BaUEN)CENRE-953  |t Annual Review of Biochemistry 
856 4 1 |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930716439&doi=10.1146%2fannurev-biochem-060614-034242&partnerID=40&md5=499d63f1a4411d27839d85d38cea58c8  |y Registro en Scopus 
856 4 0 |u https://doi.org/10.1146/annurev-biochem-060614-034242  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00664154_v84_n_p165_Naftelberg  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00664154_v84_n_p165_Naftelberg  |y Registro en la Biblioteca Digital 
961 |a paper_00664154_v84_n_p165_Naftelberg  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 85740 

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