Effects of leptin on pedunculopontine nucleus (PPN) neurons
Leptin, a hormone that regulates appetite and energy expenditure, is increased in obese individuals, although these individuals often exhibit leptin resistance. Obesity is characterized by sleep/wake disturbances, such as excessive daytime sleepiness, increased REM sleep, increased nighttime arousal...
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2013
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| 024 | 7 | |2 scopus |a 2-s2.0-84879554250 | |
| 024 | 7 | |2 cas |a Ion Channels; Leptin; Neurotransmitter Agents | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JNTRF | ||
| 100 | 1 | |a Beck, P. | |
| 245 | 1 | 0 | |a Effects of leptin on pedunculopontine nucleus (PPN) neurons |
| 260 | |c 2013 | ||
| 270 | 1 | 0 | |m Garcia-Rill, E.; Department of Neurobiology and Developmental Sciences, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, Little Rock, AR 72205, United States; email: garciarilledgar@uams.edu |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Adamantidis, A., Carter, M.C., De Lecea, L., Optogenetic deconstruction of sleep-wake circuitry in the brain (2010) Front Mol Neurosci, 2, p. 31. , 10.3389/neuro.02.031.2009 20126433 10.3389/neuro.02.031.2009 | ||
| 504 | |a Ahima, R.S., Flier, J.S., Leptin (2000) Annu Rev Physiol, 62, pp. 413-437. , 10.1146/annurev.physiol.62.1.413 10845097 10.1146/annurev.physiol.62.1. 413 1:CAS:528:DC%2BD3cXltlGrsbs%3D | ||
| 504 | |a Ahima, R.S., Bjorbaek, C., Osei, S., Flier, J.S., Regulation of neuronal and glial proteins by leptin: Implications for brain development (1999) Endocrinology, 140 (6), pp. 2755-2762. , 10342866 10.1210/en.140.6.2755 1:CAS:528:DyaK1MXjtlKhtbk%3D | ||
| 504 | |a Aldabal, L., Bahammam, A.S., Metabolic, endocrine, and immune consequences of sleep deprivation (2011) Open Respir Medicine J, 5, pp. 31-43. , 10.2174/1874306401105010031 10.2174/1874306401105010031 1:CAS:528:DC%2BC3MXhtFWiu7zF | ||
| 504 | |a Beccuti, G., Pannain, S., Sleep and obesity (2011) Curr Opin Clin Nutr Metab Care, 14 (4), pp. 402-412. , 10.1097/MCO.0b013e3283479109 21659802 10.1097/MCO.0b013e3283479109 | ||
| 504 | |a Carter, M.E., Brill, J., Bonnavion, P., Huguenard, J.R., Huerta, R., De Lecea, L., Mechanism for hypocretin-mediated sleep-to-wake transitions (2012) Proc Natl Acad Sci USA, 109 (39), pp. 2635-E2644. , 10.1073/pnas.1202526109 22955882 10.1073/pnas.1202526109 1:CAS:528:DC%2BC38XhsFCrtrvL | ||
| 504 | |a Cottrell, E.C., Cripps, R.L., Duncan, J.S., Barrett, P., Mercer, J.G., Herwig, A., Ozanne, S.E., Developmental changes in hypothalamic leptin receptor: Relationship with the postnatal leptin surge and energy balance neuropeptides in the postnatal rat (2009) Am J Physiol Regul Integr Comp Physiol, 296 (3), pp. 631-R639. , 10.1152/ajpregu.90690.2008 19144754 10.1152/ajpregu.90690.2008 1:CAS:528:DC%2BD1MXjtFGktLg%3D | ||
| 504 | |a Crill, W.E., Persistent sodium current in mammalian central neurons (1996) Annu Rev Physiol, 58, pp. 349-362. , 10.1146/annurev.ph.58.030196.002025 8815799 10.1146/annurev.ph.58.030196. 002025 1:CAS:528:DyaK28XhvVahtrw%3D | ||
| 504 | |a Datta, S., Desarnaud, F., Protein kinase A in the pedunculopontine tegmental nucleus of rat contributes to regulation of rapid eye movement sleep (2010) J Neurosci off J Soc Neurosci, 30 (37), pp. 12263-12273. , 10.1523/jneurosci.1563-10.2010 10.1523/JNEUROSCI.1563-10.2010 1:CAS:528:DC%2BC3cXht1Wgt7zF | ||
| 504 | |a Desarnaud, F., Macone, B.W., Datta, S., Activation of extracellular signal-regulated kinase signaling in the pedunculopontine tegmental cells is involved in the maintenance of sleep in rats (2011) J Neurochem, 116 (4), pp. 577-587. , 10.1111/j.1471-4159.2010.07146.x 21166678 10.1111/j.1471-4159.2010.07146. x 1:CAS:528:DC%2BC3MXisFKksrY%3D | ||
| 504 | |a Dixon, J.B., Dixon, M.E., Anderson, M.L., Schachter, L., O'Brien, P.E., Daytime sleepiness in the obese: Not as simple as obstructive sleep apnea (2007) Obesity (Silver Spring, MD), 15 (10), pp. 2504-2511. , 10.1038/oby.2007.297 10.1038/oby.2007.297 | ||
| 504 | |a Durakoglugil, M., Irving, A.J., Harvey, J., Leptin induces a novel form of NMDA receptor-dependent long-term depression (2005) J Neurochem, 95 (2), pp. 396-405. , 10.1111/j.1471-4159.2005.03375.x 16086687 10.1111/j.1471-4159.2005.03375. x 1:CAS:528:DC%2BD2MXhtFegu7vK | ||
| 504 | |a Elmquist, J.K., Bjorbaek, C., Ahima, R.S., Flier, J.S., Saper, C.B., Distributions of leptin receptor mRNA isoforms in the rat brain (1998) J Comp Neurol, 395 (4), pp. 535-547. , 9619505 10.1002/(SICI)1096-9861(19980615)395:4<535: AID-CNE9>3.0.CO;2-2 1:CAS:528:DyaK1cXjt1KgsLs%3D | ||
| 504 | |a Gan, Y., Zhang, Y., Digirolamo, D.J., Jiang, J., Wang, X., Cao, X., Zinn, K.R., Frank, S.J., Deletion of IGF-I receptor (IGF-IR) in primary osteoblasts reduces GH-induced STAT5 signaling (2010) Mol Endocrinol (Baltimore, MD), 24 (3), pp. 644-656. , 10.1210/me.2009-0357 10.1210/me.2009-0357 1:CAS:528:DC%2BC3cXjt1ehs78%3D | ||
| 504 | |a Garcia-Rill, E., Disorders of the reticular activating system (1997) Med Hypotheses, 49 (5), pp. 379-387. , 9421802 10.1016/S0306-9877(97)90083-9 1:STN:280:DyaK1c%2FotlGrsg%3D%3D | ||
| 504 | |a Garcia-Rill, E., Sleep and arousal states: Reticular activating system (2009) New Encycl Neurosci, 8, pp. 137-143. , 10.1016/B978-008045046-9.01767-8 | ||
| 504 | |a Garcia-Rill, E., Charlesworth, A., Heister, D., Ye, M., Hayar, A., The developmental decrease in REM sleep: The role of transmitters and electrical coupling (2008) Sleep, 31 (5), pp. 673-690. , 18517037 | ||
| 504 | |a Herold, K.F., Hemmings, Jr.H.C., Sodium channels as targets for volatile anesthetics (2012) Front Pharmacol, 3, p. 50. , 10.3389/fphar.2012.00050 22479247 10.3389/fphar.2012.00050 1:CAS:528:DC%2BC38XnsV2jtbc%3D | ||
| 504 | |a Jouvet-Mounier, D., Astic, L., Lacote, D., Ontogenesis of the states of sleep in rat, cat, and guinea pig during the first postnatal month (1970) Dev Psychobiol, 2 (4), pp. 216-239. , 10.1002/dev.420020407 5527153 10.1002/dev.420020407 1:STN:280: DyaE3s7jtlektQ%3D%3D | ||
| 504 | |a Kamondi, A., Williams, J.A., Hutcheon, B., Reiner, P.B., Membrane properties of mesopontine cholinergic neurons studied with the whole-cell patch-clamp technique: Implications for behavioral state control (1992) J Neurophysiol, 68 (4), pp. 1359-1372. , 1359028 1:STN:280:DyaK3s%2FlslOlsA%3D%3D | ||
| 504 | |a Kezunovic, N., Urbano, F.J., Simon, C., Hyde, J., Smith, K., Garcia-Rill, E., Mechanism behind gamma band activity in the pedunculopontine nucleus (2011) Eur J Neurosci, 34 (3), pp. 404-415. , 10.1111/j.1460-9568.2011.07766.x 21722210 10.1111/j.1460-9568.2011.07766. x | ||
| 504 | |a Kobayashi, T., Good, C., Mamiya, K., Skinner, R.D., Garcia-Rill, E., Development of REM sleep drive and clinical implications (2004) J Appl Physiol (Bethesda, MD: 1985), 96 (2), pp. 735-746. , 10.1152/japplphysiol.00908.2003 10.1152/japplphysiol.00908.2003 1:STN:280:DC%2BD2c%2FhvVCrsA%3D%3D | ||
| 504 | |a Krebs, D.L., Hilton, D.J., SOCS: Physiological suppressors of cytokine signaling (2000) J Cell Sci, 113 (PART 16), pp. 2813-2819. , 10910765 1:CAS:528:DC%2BD3cXmslygtrs%3D | ||
| 504 | |a Leonard, C.S., Llinas, R., Serotonergic and cholinergic inhibition of mesopontine cholinergic neurons controlling REM sleep: An in vitro electrophysiological study (1994) Neuroscience, 59 (2), pp. 309-330. , 8008195 10.1016/0306-4522(94)90599-1 1:CAS:528:DyaK2cXitlKrs74%3D | ||
| 504 | |a Lindsley, D.B., Bowden, J.W., Magoun, H.W., Effect upon the EEG of acute injury to the brain stem activating system (1949) Electroencephalogr Clin Neurophysiol, 1 (4), pp. 475-486. , 18421836 1:STN:280:DC%2BD1c3mtVGisg%3D%3D | ||
| 504 | |a Luthi, A., McCormick, D.A., H-current: Properties of a neuronal and network pacemaker (1998) Neuron, 21 (1), pp. 9-12. , 9697847 10.1016/S0896-6273(00)80509-7 1:CAS:528:DyaK1cXltFyiu7o%3D | ||
| 504 | |a Moruzzi, G., Magoun, H.W., Brain stem reticular formation and activation of the EEG. 1949 (1995) J Neuropsychiatry Clin Neurosci, 7 (2), pp. 251-267. , 7626974 1:STN:280:DyaK2MzltlSmtQ%3D%3D | ||
| 504 | |a Niswender, K.D., Morton, G.J., Stearns, W.H., Rhodes, C.J., Myers, Jr.M.G., Schwartz, M.W., Intracellular signalling. Key enzyme in leptin-induced anorexia (2001) Nature, 413 (6858), pp. 794-795. , 10.1038/35101657 11677594 10.1038/35101657 1:CAS:528:DC%2BD3MXotFyksb4%3D | ||
| 504 | |a O'Malley, D., Irving, A.J., Harvey, J., Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels (2005) FASEB J off Publ Fed Am Soc Exp Biol, 19 (13), pp. 1917-1919. , 10.1096/fj.05-4166fje | ||
| 504 | |a Roffwarg, H.P., Muzio, J.N., Dement, W.C., Ontogenetic development of the human sleep-dream cycle (1966) Science (New York, NY), 152 (3722), pp. 604-619. , 10.1126/science.152.3722.604 10.1126/science.152.3722.604 1:STN:280:DC%2BC3cvgslCjuw%3D%3D | ||
| 504 | |a Rutters, F., Gonnissen, H.K., Hursel, R., Lemmens, S.G., Martens, E.A., Westerterp-Plantenga, M.S., Distinct associations between energy balance and the sleep characteristics slow wave sleep and rapid eye movement sleep (2012) Int J Obes, , 10.1038/ijo.2011.250 | ||
| 504 | |a Sah, N., Rajput, S.K., Singh, J.N., Meena, C.L., Jain, R., Sikdar, S.K., Sharma, S.S., L-pGlu-(2-propyl)-l-His-l-ProNH(2) attenuates 4-aminopyridine-induced epileptiform activity and sodium current: A possible action of new thyrotropin-releasing hormone analog for its anticonvulsant potential (2011) Neuroscience, 199, pp. 74-85. , 10.1016/j.neuroscience.2011.10.008 22037285 10.1016/j.neuroscience.2011. 10.008 1:CAS:528:DC%2BC3MXhs1SgsLvP | ||
| 504 | |a Sahu, A., Intracellular leptin-signaling pathways in hypothalamic neurons: The emerging role of phosphatidylinositol-3 kinase-phosphodiesterase-3B-cAMP pathway (2011) Neuroendocrinology, 93 (4), pp. 201-210. , 10.1159/000326785 21464566 10.1159/000326785 1:CAS:528: DC%2BC3MXnslenurk%3D | ||
| 504 | |a Shanley, L.J., Irving, A.J., Rae, M.G., Ashford, M.L., Harvey, J., Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels (2002) Nat Neurosci, 5 (4), pp. 299-300. , 10.1038/nn824 11889470 10.1038/nn824 1:CAS:528:DC%2BD38Xis1Kis70%3D | ||
| 504 | |a Shanley, L.J., O'Malley, D., Irving, A.J., Ashford, M.L., Harvey, J., Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels (2002) J Physiol, 545 (PART 3), pp. 933-944. , 12482897 10.1113/jphysiol.2002.029488 1:CAS:528:DC%2BD3sXpvV2rtg%3D%3D | ||
| 504 | |a Shouse, M.N., Siegel, J.M., Pontine regulation of REM sleep components in cats: Integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleep (1992) Brain Res, 571 (1), pp. 50-63. , 1611494 10.1016/0006-8993(92)90508-7 1:STN:280:DyaK38zgsF2jtw%3D%3D | ||
| 504 | |a Simon, C., Kezunovic, N., Ye, M., Hyde, J., Hayar, A., Williams, D.K., Garcia-Rill, E., Gamma band unit activity and population responses in the pedunculopontine nucleus (2010) J Neurophysiol, 104 (1), pp. 463-474. , 10.1152/jn.00242.2010 20463196 10.1152/jn.00242.2010 1:CAS:528: DC%2BC3cXhtVekt7nJ | ||
| 504 | |a Spiegel, K., Knutson, K., Leproult, R., Tasali, E., Van Cauter, E., Sleep loss: A novel risk factor for insulin resistance and Type 2 diabetes (2005) J Appl Physiol (Bethesda, MD: 1985), 99 (5), pp. 2008-2019. , 10.1152/japplphysiol.00660.2005 10.1152/japplphysiol.00660.2005 1:CAS:528:DC%2BD2MXht1Crur%2FK | ||
| 504 | |a Steriade, M., Datta, S., Pare, D., Oakson, G., Curro Dossi, R.C., Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems (1990) J Neurosci off J Soc Neurosci, 10 (8), pp. 2541-2559. , 1:STN:280:DyaK3czlsVykug%3D%3D | ||
| 504 | |a Storm, J.F., Action potential repolarization and a fast after-hyperpolarization in rat hippocampal pyramidal cells (1987) J Physiol, 385, pp. 733-759. , 2443676 1:STN:280:DyaL1c%2FhtVOmtQ%3D%3D | ||
| 504 | |a Taheri, S., Lin, L., Austin, D., Young, T., Mignot, E., Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index (2004) PLoS Med, 1 (3), p. 62. , 10.1371/journal.pmed.0010062 15602591 10.1371/journal.pmed.0010062 | ||
| 504 | |a Takakusaki, K., Kitai, S.T., Ionic mechanisms involved in the spontaneous firing of tegmental pedunculopontine nucleus neurons of the rat (1997) Neuroscience, 78 (3), pp. 771-794. , 9153657 10.1016/S0306-4522(96)00540-4 1:CAS:528:DyaK2sXjtVenu7o%3D | ||
| 504 | |a Taylor, C.P., Na+ currents that fail to inactivate (1993) Trends Neurosci, 16 (11), pp. 455-460. , 7507618 10.1016/0166-2236(93)90077-Y 1:CAS:528:DyaK2cXisl2guw%3D%3D | ||
| 504 | |a Udagawa, J., Hatta, T., Hashimoto, R., Otani, H., Roles of leptin in prenatal and perinatal brain development (2007) Congenit Anom, 47 (3), pp. 77-83. , 10.1111/j.1741-4520.2007.00150.x 10.1111/j.1741-4520.2007.00150.x 1:CAS:528:DC%2BD2sXhtFejtbrM | ||
| 504 | |a Urbano, F.J., Kezunovic, N., Hyde, J., Simon, C., Beck, P., Garcia-Rill, E., Gamma band activity in the reticular activating system (2012) Front Neurol, 3, p. 6. , 10.3389/fneur.2012.00006 22319508 10.3389/fneur.2012.00006 1:CAS:528:DC%2BC38Xis12nsrs%3D | ||
| 504 | |a Vgontzas, A.N., Bixler, E.O., Tan, T.L., Kantner, D., Martin, L.F., Kales, A., Obesity without sleep apnea is associated with daytime sleepiness (1998) Arch Intern Med, 158 (12), pp. 1333-1337. , 9645828 10.1001/archinte.158.12.1333 1:STN:280:DyaK1czgslOlsg%3D%3D | ||
| 504 | |a Yang, M.J., Wang, F., Wang, J.H., Wu, W.N., Hu, Z.L., Cheng, J., Yu, D.F., Chen, J.G., PI3 K integrates the effects of insulin and leptin on large-conductance Ca2+-activated K+ channels in neuropeptide y neurons of the hypothalamic arcuate nucleus (2010) Am J Physiol Endocrinol Metab, 298 (2), pp. 193-E201. , 10.1152/ajpendo.00155.2009 19671839 10.1152/ajpendo.00155.2009 1:CAS:528:DC%2BC3cXhvVyku74%3D | ||
| 504 | |a Yang, R.H., Wang, W.T., Hou, X.H., Hu, S.J., Chen, J.Y., Ionic mechanisms of the effects of sleep deprivation on excitability in hippocampal pyramidal neurons (2010) Brain Res, 1343, pp. 135-142. , 10.1016/j.brainres.2010.05.019 20471377 10.1016/j.brainres.2010.05.019 1:CAS:528:DC%2BC3cXnvVyhu7g%3D | ||
| 520 | 3 | |a Leptin, a hormone that regulates appetite and energy expenditure, is increased in obese individuals, although these individuals often exhibit leptin resistance. Obesity is characterized by sleep/wake disturbances, such as excessive daytime sleepiness, increased REM sleep, increased nighttime arousals, and decreased percentage of total sleep time. Several studies have shown that short sleep duration is highly correlated with decreased leptin levels in both animal and human models. Arousal and rapid eye movement (REM) sleep are regulated by the cholinergic arm of the reticular activating system, the pedunculopontine nucleus (PPN). The goal of this project was to determine the role of leptin in the PPN, and thus in obesity-related sleep disorders. Whole-cell patch-clamp recordings were conducted on PPN neurons in 9- to 17-day-old rat brainstem slices. Leptin decreased action potential (AP) amplitude, AP frequency, and h-current (I H). These findings suggest that leptin causes a blockade of Na+ channels. Therefore, we conducted an experiment to test the effects of leptin on Na+ conductance. To determine the average voltage dependence of this conductance, results from each cell were equally weighted by expressing conductance as a fraction of the maximum conductance in each cell. I Na amplitude was decreased in a dose-dependent manner, suggesting a direct effect of leptin on these channels. The average decrease in Na+ conductance by leptin was ~40 %. We hypothesize that leptin normally decreases activity in the PPN by reducing I H and I Na currents, and that in states of leptin dysregulation (i.e., leptin resistance) this effect may be blunted, therefore causing increased arousal and REM sleep drive, and ultimately leading to sleep-related disorders. © 2012 Springer-Verlag Wien. |l eng | |
| 593 | |a Department of Neurobiology and Developmental Sciences, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 847, Little Rock, AR 72205, United States | ||
| 593 | |a IFIBYNE, CONICET, University of Buenos Aires Ciudad Universitaria, Pabellon 2, Piso 2 (C14228EHA), Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a AROUSAL |
| 690 | 1 | 0 | |a HYPERPOLARIZATION-ACTIVATED CATION CURRENT |
| 690 | 1 | 0 | |a SODIUM CURRENT |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS |
| 690 | 1 | 0 | |a ION CHANNEL |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a ACTION POTENTIAL |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a AROUSAL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a NERVE CELL |
| 690 | 1 | 0 | |a NEWBORN |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PATCH CLAMP |
| 690 | 1 | 0 | |a PEDUNCULOPONTINE TEGMENTAL NUCLEUS |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a REM SLEEP |
| 690 | 1 | 0 | |a SLEEP DISORDER |
| 690 | 1 | 0 | |a SODIUM CONDUCTANCE |
| 690 | 1 | 0 | |a SODIUM CURRENT |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BIOPHYSICS |
| 690 | 1 | 0 | |a CHANNEL GATING |
| 690 | 1 | 0 | |a CYTOLOGY |
| 690 | 1 | 0 | |a DOSE RESPONSE |
| 690 | 1 | 0 | |a DRUG EFFECTS |
| 690 | 1 | 0 | |a ELECTROSTIMULATION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NERVE CELL |
| 690 | 1 | 0 | |a NONPARAMETRIC TEST |
| 690 | 1 | 0 | |a PATCH CLAMP TECHNIQUE |
| 690 | 1 | 0 | |a PEDUNCULOPONTINE TEGMENTAL NUCLEUS |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a SPRAGUE DAWLEY RAT |
| 690 | 1 | 0 | |a ACTION POTENTIALS |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANIMALS, NEWBORN |
| 690 | 1 | 0 | |a BIOPHYSICAL PROCESSES |
| 690 | 1 | 0 | |a BIOPHYSICS |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a ELECTRIC STIMULATION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a IN VITRO TECHNIQUES |
| 690 | 1 | 0 | |a ION CHANNEL GATING |
| 690 | 1 | 0 | |a ION CHANNELS |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NEURONS |
| 690 | 1 | 0 | |a NEUROTRANSMITTER AGENTS |
| 690 | 1 | 0 | |a PATCH-CLAMP TECHNIQUES |
| 690 | 1 | 0 | |a PEDUNCULOPONTINE TEGMENTAL NUCLEUS |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a STATISTICS, NONPARAMETRIC |
| 700 | 1 | |a Urbano, F.J. | |
| 700 | 1 | |a Williams, D.K. | |
| 700 | 1 | |a Garcia-Rill, E. | |
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