Coupling between transcription and alternative splicing
The scenario of alternative splicing regulation is far more complex than the classical picture of a pre-mRNA being processed post-transcriptionally in more than one way. Introns are efficiently removed while transcripts are still being synthesized, supporting the idea of a co-transcriptional regulat...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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2013
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 23802caa a22019817a 4500 | ||
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| 001 | PAPER-24122 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205555.0 | ||
| 008 | 190411s2013 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84891753215 | |
| 024 | 7 | |2 cas |a Chromatin; RNA Polymerase II; RNA Precursors | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Schor, I.E. | |
| 245 | 1 | 0 | |a Coupling between transcription and alternative splicing |
| 260 | |c 2013 | ||
| 270 | 1 | 0 | |m Kornblihtt, A.R.; Laboratorio de Fisiologia y Biologia Molecular, Departmento de Fisiologia, Biologia Molecular y Celular, Universidad de Buenos Aires, Ciudad Universitaria PAB. II, 20 Piso, Buenos Aires 1428, Argentina; email: ark@fbmc.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Srebrow, A., Kornblihtt, A.R., The connection between splicing and cancer (2006) J Cell Sci, 119 (13), pp. 2635-2641 | ||
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| 520 | 3 | |a The scenario of alternative splicing regulation is far more complex than the classical picture of a pre-mRNA being processed post-transcriptionally in more than one way. Introns are efficiently removed while transcripts are still being synthesized, supporting the idea of a co-transcriptional regulation of alternative splicing. Evidence of a functional coupling between splicing and transcription has recently emerged as it was observed that properties of one process may affect the outcome of the other. Co-transcriptionality is thought to improve splicing efficiency and kinetics by directing the nascent pre-mRNA into proper spliceosome assembly and favoring splicing factor recruitment. Two models have been proposed to explain the coupling of transcription and alternative splicing: in the recruitment model, promoters and pol II status affect the recruitment to the transcribing gene of splicing factors or bifunctional factors acting on both transcription and splicing; in the kinetic model, differences in the elongation rate of pol II would determine the timing in which splicing sites are presented, and thus the outcome of alternative splicing decisions. In the later model, chromatin structure has emerged as a key regulator. Although definitive evidence for transcriptionally coupled alternative splicing alterations in tumor development or cancer pathogenesis is still missing, many alternative splicing events altered in cancer might be subject to transcription-splicing coupling regulation. © Springer-Verlag Berlin Heidelberg 2013. |l eng | |
| 593 | |a Laboratorio de Fisiologia y Biologia Molecular, Departmento de Fisiologia, Biologia Molecular y Celular, Universidad de Buenos Aires, Ciudad Universitaria PAB. II, 20 Piso, Buenos Aires 1428, Argentina | ||
| 690 | 1 | 0 | |a ALTERNATIVE SPLICING |
| 690 | 1 | 0 | |a CHROMATIN |
| 690 | 1 | 0 | |a CO-TRANSCRIPTIONAL SPLICING |
| 690 | 1 | 0 | |a KINETIC MODEL |
| 690 | 1 | 0 | |a RNA POLYMERASE II-CTD |
| 690 | 1 | 0 | |a TRANSCRIPTION-SPLICING COUPLING |
| 690 | 1 | 0 | |a RNA POLYMERASE II |
| 690 | 1 | 0 | |a CHROMATIN |
| 690 | 1 | 0 | |a RNA POLYMERASE II |
| 690 | 1 | 0 | |a RNA PRECURSOR |
| 690 | 1 | 0 | |a ALTERNATIVE RNA SPLICING |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CANCER GENETICS |
| 690 | 1 | 0 | |a CARBOXY TERMINAL SEQUENCE |
| 690 | 1 | 0 | |a CHEMICAL REACTION KINETICS |
| 690 | 1 | 0 | |a CHROMATIN STRUCTURE |
| 690 | 1 | 0 | |a EXON |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a HISTONE METHYLATION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a INTRACELLULAR SIGNALING |
| 690 | 1 | 0 | |a INTRON |
| 690 | 1 | 0 | |a MOLECULAR INTERACTION |
| 690 | 1 | 0 | |a MOLECULAR MODEL |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN SECONDARY STRUCTURE |
| 690 | 1 | 0 | |a RNA TRANSLATION |
| 690 | 1 | 0 | |a TRANSCRIPTION ELONGATION |
| 690 | 1 | 0 | |a TRANSCRIPTION REGULATION |
| 690 | 1 | 0 | |a CHROMATIN |
| 690 | 1 | 0 | |a GENETIC TRANSCRIPTION |
| 690 | 1 | 0 | |a RNA SPLICING |
| 690 | 1 | 0 | |a ALTERNATIVE SPLICING |
| 690 | 1 | 0 | |a CHROMATIN |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a RNA POLYMERASE II |
| 690 | 1 | 0 | |a RNA PRECURSORS |
| 690 | 1 | 0 | |a RNA SPLICING |
| 690 | 1 | 0 | |a TRANSCRIPTION, GENETIC |
| 700 | 1 | |a Gómez Acuña, L.I. | |
| 700 | 1 | |a Kornblihtt, A.R. | |
| 700 | 1 | |a Wu J.Y. | |
| 773 | 0 | |d 2013 |g v. 158 |h pp. 1-24 |p Cancer Treat. Res. |x 09273042 |z 9783642316586 |t Cancer Treatment and Research | |
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| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-642-31659-3_1 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_09273042_v158_n_p1_Schor |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09273042_v158_n_p1_Schor |y Registro en la Biblioteca Digital |
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