Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors
Galectin-8 (Gal-8) is a 'tandem-repeat'-type galectin, which possesses two carbohydrate recognition domains connected by a linker peptide. Gal-8 complexity is related to the alternative splicing of its mRNA precursor, which is known to generate isoforms. Regarding its carbohydrate-binding...
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Histology and Histopathology
2014
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
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| LEADER | 21705caa a22014657a 4500 | ||
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| 001 | PAPER-24092 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230607131917.0 | ||
| 008 | 190411s2014 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84905663943 | |
| 024 | 7 | |2 cas |a Galectins; LGALS8 protein, human; Tumor Markers, Biological | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a HIHIE | ||
| 100 | 1 | |a Elola, M.T. | |
| 245 | 1 | 0 | |a Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors |
| 260 | |b Histology and Histopathology |c 2014 | ||
| 270 | 1 | 0 | |m Elola, M. T.; Universidad de Buenos Aires, Junín 956 (C1113), Buenos Aires, Argentina; email: mt_elola@yahoo.com |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Tribulatti, M.V., Mucci, J., Cattaneo, V., Aguero, F., Gilmartin, T., Head, S.R., Campetella, O., Galectin-8 induces apoptosis in the CD4(high)CD8(high) thymocyte subpopulation (2007) Glycobiology, 17, pp. 1404-1412 | ||
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| 504 | |a Troncoso, M.F., Elola, M.T., Croci, D.O., Rabinovich, G.A., Integrating structure and function of 'tandem-repeat' galectins (2012) Front. Biosci. (Schol Ed), 4, pp. 864-887 | ||
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| 504 | |a Yoshida, H., Yamashita, S., Teraoka, M., Itoh, A., Nakakita, S., Nishi, N., Kamitori, S., X-ray structure of a protease-resistant mutant form of human galectin-8 with two carbohydrate recognition domains (2012) FEBS J., 279, pp. 3937-3951 | ||
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| 504 | |a Zick, Y., Eisenstein, M., Goren, R.A., Hadari, Y.R., Levy, Y., Ronen, D., Role of galectin-8 as a modulator of cell adhesion and cell growth (2004) Glycoconj. J., 19, pp. 517-526 | ||
| 520 | 3 | |a Galectin-8 (Gal-8) is a 'tandem-repeat'-type galectin, which possesses two carbohydrate recognition domains connected by a linker peptide. Gal-8 complexity is related to the alternative splicing of its mRNA precursor, which is known to generate isoforms. Regarding its carbohydrate-binding specificity, Gal-8 has a unique feature among galectins, since its C-terminal domain has higher affinity for N-glycan-type branched oligosaccharides, while its N-terminal domain shows strong affinity for α2-3-sialylated or 3'-sulfated ß-galactosides. We integrate here the available information on Gal-8 expression in different tumor types and attempt to elucidate associations of its expression and localization during tumor progression with the overarching goal of analyzing its potential applications in diagnosis and prognosis. Differential diagnosis is still a prime concern in tumor pathology, and Gal-8 could be of great value in some types of primary or secondary tumors (i.e. papillary thyroid carcinoma, advanced colon carcinoma from patients with distant metastases, or metastases from primary lung carcinoma). The prognostic value of Gal-8 has been described for laryngeal carcinoma as well as advanced colon carcinoma. Further studies are needed to explain the relevance of Gal-8 and its isoforms in tumor pathology and their different intra- or extracellular roles (cytoplasmic, nuclear or extracellular) in tumor biology. |l eng | |
| 593 | |a Institute of Biochemistry and Biophysics (IQUIFIB), UBA-CONICET, Department of Biological Chemistry, School of Pharmacy and Biochemistry. University of Buenos Aires, Argentina | ||
| 593 | |a Laboratory of Functional Glycomics, IQUIBICEN, CONICET, Department of Biological Chemistry, School of Exact and Natural Sciences, University of Buenos Aires, Argentina | ||
| 593 | |a Laboratory of Immunopathology, Institute of Experimental Biology and Medicine (IBYME), NICET, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a GALECTIN-8 |
| 690 | 1 | 0 | |a ISOFORMS |
| 690 | 1 | 0 | |a LUNG |
| 690 | 1 | 0 | |a PROSTATE |
| 690 | 1 | 0 | |a TUMORS |
| 690 | 1 | 0 | |a GALECTIN |
| 690 | 1 | 0 | |a LGALS8 PROTEIN, HUMAN |
| 690 | 1 | 0 | |a TUMOR MARKER |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a NEOPLASM |
| 690 | 1 | 0 | |a PATHOLOGY |
| 690 | 1 | 0 | |a GALECTINS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a NEOPLASMS |
| 690 | 1 | 0 | |a TUMOR MARKERS, BIOLOGICAL |
| 700 | 1 | |a Ferragut, F. | |
| 700 | 1 | |a Cárdenas Delgado, V.M. | |
| 700 | 1 | |a Nugnes, L.G. | |
| 700 | 1 | |a Gentilini, L. | |
| 700 | 1 | |a Laderach, D. | |
| 700 | 1 | |a Troncoso, M.F. | |
| 700 | 1 | |a Compagno, D. | |
| 700 | 1 | |a Wolfenstein-Todel, C. | |
| 700 | 1 | |a Rabinovich, G.A. | |
| 773 | 0 | |d Histology and Histopathology, 2014 |g v. 29 |h pp. 1093-1105 |k n. 9 |p Histol. Histopathol. |x 02133911 |t Histology and Histopathology | |
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