Oral administration of angiotensin-(1-7) ameliorates type 2 diabetes in rats
Diabetes mellitus type 2 (DM2) is a disease with increasing importance in modern societies and insufficient treatment options. Pharmacological stimulation of insulin signaling, which is blunted in DM2, is a promising approach to treat this disease. It has been shown that activation of the angiotensi...
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| Otros Autores: | , , , , , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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Springer Verlag
2014
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 21428caa a22018617a 4500 | ||
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| 001 | PAPER-23957 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205544.0 | ||
| 008 | 190411s2014 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84898472204 | |
| 024 | 7 | |2 cas |a 2 hydroxypropyl beta cyclodextrin, 94035-02-6; angiotensin[1-7], 39386-80-6; glucose, 50-99-7, 84778-64-3; glucose transporter 4, 188071-24-1; insulin, 9004-10-8; insulin receptor substrate 1, 175335-32-7; protein kinase B, 148640-14-6 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JMLME | ||
| 100 | 1 | |a Santos, S.H.S. | |
| 245 | 1 | 0 | |a Oral administration of angiotensin-(1-7) ameliorates type 2 diabetes in rats |
| 260 | |b Springer Verlag |c 2014 | ||
| 270 | 1 | 0 | |m Santos, R.A.S.; Department of Physiology and Biophysics, Biological Sciences Institute (ICB), Federal University of Minas Gerais (UFMG), Av Antonio Carlos 6627-ICB, 31270-901 Belo Horizonte MG, Brazil; email: robsonsant@gmail.com |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Mario, E.G., Santos, S.H., Ferreira, A.V., Bader, M., Santos, R.A., Botion, L.M., Angiotensin-(1-7) Mas-receptor deficiency decreases peroxisome proliferator-activated receptor gamma expression in adipocytes (2012) Peptides, 33, pp. 174-177. , 1:CAS:528:DC%2BC38XovF2msg%3D%3D 22119778 10.1016/j.peptides.2011.11.014 | ||
| 520 | 3 | |a Diabetes mellitus type 2 (DM2) is a disease with increasing importance in modern societies and insufficient treatment options. Pharmacological stimulation of insulin signaling, which is blunted in DM2, is a promising approach to treat this disease. It has been shown that activation of the angiotensin (Ang)-(1-7)/Mas axis of the renin-angiotensin system leads to an improved glucose uptake. In this study, we intended to evaluate, whether this effect could be exploited therapeutically. We first confirmed that Ang-(1-7) improves insulin signaling and glucose uptake in vitro in cultured cardiomyocytes. We then evaluated the therapeutic effect of a newly developed hydro-xypropyl- β-cyclodextrin-based Ang-(1-7) nano-formulation in a novel transgenic rat model of inducible insulin resistance and DM2. The chronic administration of this compound prevented the marked elevation in blood glucose levels in these rats at a dose of 30 μg/kg, reversed the established hyperglycemic state at a dose of 100 μg/kg, and resulted in improved insulin sensitivity, reduced plasma insulin and decreased diabetic nephropathy. In conclusion, an oral Ang-(1-7) formulation reverses hyperglycemia and its consequences in an animal model of DM2 and represents a novel therapeutic option for the treatment of DM2 and other cardio-metabolic diseases. Key message: A novel rat model with inducible diabetes can be used to evaluate new therapies. Angiotensin-(1-7) is effective in an oral formulation packaged in cyclodextrine. Angiotensin-(1-7) is a promising antidiabetic drug. © 2013 Springer-Verlag Berlin Heidelberg. |l eng | |
| 593 | |a Department of Physiology and Biophysics, Biological Sciences Institute (ICB), Federal University of Minas Gerais (UFMG), Av Antonio Carlos 6627-ICB, 31270-901 Belo Horizonte MG, Brazil | ||
| 593 | |a Instituto de Química y Fisicoquímica Biológicas, Departamento de Química Biológica, Universidad de Buenos Aires, Junín 956, (1113) Buenos Aires, Argentina | ||
| 593 | |a Max-Delbrück-Center for Molecular Medicine (MDC), Buch, 13125 Berlin, Germany | ||
| 690 | 1 | 0 | |a ANGIOTENSIN-(1-7) |
| 690 | 1 | 0 | |a ANTIDIABETIC |
| 690 | 1 | 0 | |a RNA INTERFERENCE |
| 690 | 1 | 0 | |a 2 HYDROXYPROPYL BETA CYCLODEXTRIN |
| 690 | 1 | 0 | |a ANGIOTENSIN[1-7] |
| 690 | 1 | 0 | |a GLUCOSE |
| 690 | 1 | 0 | |a GLUCOSE TRANSPORTER 4 |
| 690 | 1 | 0 | |a GLYCOGEN SYNTHASE KINASE 3BETA |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a INSULIN RECEPTOR |
| 690 | 1 | 0 | |a INSULIN RECEPTOR SUBSTRATE 1 |
| 690 | 1 | 0 | |a PROTEIN KINASE B |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL CELL CULTURE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ANTIDIABETIC ACTIVITY |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BODY WEIGHT |
| 690 | 1 | 0 | |a CELL ISOLATION |
| 690 | 1 | 0 | |a CELL MEMBRANE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DIABETIC NEPHROPATHY |
| 690 | 1 | 0 | |a DIURESIS |
| 690 | 1 | 0 | |a DOWN REGULATION |
| 690 | 1 | 0 | |a DRUG FORMULATION |
| 690 | 1 | 0 | |a ENZYME PHOSPHORYLATION |
| 690 | 1 | 0 | |a GLUCOSE BLOOD LEVEL |
| 690 | 1 | 0 | |a GLUCOSE TRANSPORT |
| 690 | 1 | 0 | |a HEART MUSCLE CELL |
| 690 | 1 | 0 | |a HISTOLOGY |
| 690 | 1 | 0 | |a HYPERGLYCEMIA |
| 690 | 1 | 0 | |a IMMUNOBLOTTING |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a INSULIN BLOOD LEVEL |
| 690 | 1 | 0 | |a INSULIN RESISTANCE |
| 690 | 1 | 0 | |a INSULIN SENSITIVITY |
| 690 | 1 | 0 | |a LONG TERM CARE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NEWBORN |
| 690 | 1 | 0 | |a NON INSULIN DEPENDENT DIABETES MELLITUS |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PREVENTION STUDY |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a THERAPY EFFECT |
| 690 | 1 | 0 | |a URINE VOLUME |
| 690 | 1 | 0 | |a ADMINISTRATION, ORAL |
| 690 | 1 | 0 | |a ANGIOTENSIN I |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANIMALS, NEWBORN |
| 690 | 1 | 0 | |a DEOXYGLUCOSE |
| 690 | 1 | 0 | |a DIABETES MELLITUS, TYPE 2 |
| 690 | 1 | 0 | |a HYPERGLYCEMIA |
| 690 | 1 | 0 | |a HYPOGLYCEMIC AGENTS |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MYOCYTES, CARDIAC |
| 690 | 1 | 0 | |a PEPTIDE FRAGMENTS |
| 690 | 1 | 0 | |a PHOSPHORYLATION |
| 690 | 1 | 0 | |a PROTO-ONCOGENE PROTEINS C-AKT |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 650 | 1 | 7 | |2 spines |a DIABETES |
| 700 | 1 | |a Giani, J.F. | |
| 700 | 1 | |a Burghi, V. | |
| 700 | 1 | |a Miquet, J.G. | |
| 700 | 1 | |a Qadri, F. | |
| 700 | 1 | |a Braga, J.F. | |
| 700 | 1 | |a Todiras, M. | |
| 700 | 1 | |a Kotnik, K. | |
| 700 | 1 | |a Alenina, N. | |
| 700 | 1 | |a Dominici, F.P. | |
| 700 | 1 | |a Santos, R.A.S. | |
| 700 | 1 | |a Bader, M. | |
| 773 | 0 | |d Springer Verlag, 2014 |g v. 92 |h pp. 255-265 |k n. 3 |p J. Mol. Med. |x 09462716 |t Journal of Molecular Medicine | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898472204&doi=10.1007%2fs00109-013-1087-0&partnerID=40&md5=1f97e102b2e0be940608d8dd68a71c17 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00109-013-1087-0 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_09462716_v92_n3_p255_Santos |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09462716_v92_n3_p255_Santos |y Registro en la Biblioteca Digital |
| 961 | |a paper_09462716_v92_n3_p255_Santos |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 84910 | ||