Spontaneous genetic damage in the tegu lizard (Tupinambis merianae): The effect of age
Several studies indicate that certain factors such as age, sex or nutritional status among others, may affect the level of DNA damage, both induced and spontaneous, so it is very important to consider them for a more accurate interpretation of the findings. The aim of this study was to analyze the i...
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Elsevier
2014
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| LEADER | 15351caa a22014057a 4500 | ||
|---|---|---|---|
| 001 | PAPER-23843 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205536.0 | ||
| 008 | 190411s2014 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84899910035 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MRGMF | ||
| 100 | 1 | |a Schaumburg, L.G. | |
| 245 | 1 | 0 | |a Spontaneous genetic damage in the tegu lizard (Tupinambis merianae): The effect of age |
| 260 | |b Elsevier |c 2014 | ||
| 270 | 1 | 0 | |m Schaumburg, L.G.; Grupo de Investigación en Biología Evolutiva (GIBE), IEGEBA (CONICET-UBA), Labs. 43 y 46, FCEyN-Pabellon II-Cdad. Universi-taria, Piso 4, Intendente Güiraldes 2160, 1428EGA Capital Federal, Buenos Aires, Argentina; email: giseschaumburg@yahoo.com.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Poletta, G.L., Larriera, A., Kleinsorge, E., Mudry, M.D., Caiman latirostris (broad-snouted caiman) as a sentinel organism for genotoxic monitoring: basal values determination of micronucleus and comet assay (2008) Mutat. Res., 650, pp. 202-209 | ||
| 504 | |a Fenech, M., Bonassi, S., The effect of age, gender, diet and lifestyle on DNA damage measured using micronucleus frequency in human peripheral blood lymphocytes (2011) Mutagenesis, 26, pp. 43-49 | ||
| 504 | |a Wirzinger, G., Weltje, L., Gercken, J., Sordyl, H., Genotoxic damage in field-collected three-spined sticklebacks (Gasterosteus aculeatus L.): a suitable biomonitoring tool? (2007) Mutat. Res., 628, pp. 19-30 | ||
| 504 | |a Bolognesi, C., Perrone, E., Roggieri, P., Pampanin, D.M., Sciutto, A., Assessment of micronuclei induction in peripheral erythrocytes of fish exposed to xenobiotics under controlled conditions (2006) Aquat. Toxicol., 78, pp. 93-98 | ||
| 504 | |a Jha, A.N., Ecotoxicological applications and significance of the comet assay (2008) Mutagenesis, 23, pp. 207-221 | ||
| 504 | |a Schaumburg, L.G., Poletta, G.L., Siroski, P.A., Mudry, M.D., Baseline values of micronuclei and comet assay in the Lizard Tupinambis merianae (Teiidae, Squamata) (2012) Ecotoxicol. Environ. Saf., 84, pp. 99-103 | ||
| 504 | |a Reference ethical framework for biomedics research: ethical principles for research with laboratory, farm and wild animals (2005) Res Nro. 1047 Anexo II, , National Scientific and Technical Research Council CONICET, Buenos Aires, Argentina | ||
| 504 | |a Hall, B.J., Note on the husbandry, behaviour and breeding of captive tegu lizards Tupinambis teguixin (1978) Int. Zoo Yearb., pp. 91-101 | ||
| 504 | |a Yanosky, A.A., Mercolli, C., Some observations on the growth and related topics in juvenile tegu lizards (Tupinambis teguixin) (1992) Arch. Zootec., 41, pp. 265-278 | ||
| 504 | |a Olson, G., Hessler, J., Faith, R., Techniques for the blood collection and intravascular infusion of reptiles (1977) Lab. Anim. Sci., 25, pp. 783-786 | ||
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| 504 | |a Rodríguez Ferreiro, G., Cancino Badías, L., López-Nigro, M., Palermo, A., Mudry, M.D., Prieto González, E., Carballo, M., DNA single strand breaks in peripheral blood lymphocytes induced by three nitroimidazole derivatives (2002) Toxicol. Lett., 132, pp. 109-115 | ||
| 504 | |a Møller, P., Knudsen, L.E., Loft, S., Wallin, H., The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors (2000) Cancer Epidemiol. Biomarkers Prev., 9, pp. 1005-1015 | ||
| 504 | |a Tran, D., Moody, A.J., Fisher, A.S., Foulkes, M.E., Jha, A.N., Protective effects of selenium on mercury-induced DNA damage in mussel haemocytes (2007) Aquat. Toxicol., 84, pp. 11-18 | ||
| 504 | |a Møller, P., The alkaline comet assay: towards validation in biomonitoring of DNA damaging exposures (2006) Basic Clin. Pharmacol. Toxicol., 98, pp. 336-345 | ||
| 504 | |a Zúñiga-González, G., Torres-Bugarín, O., Luna-Aguirre, J., González-Rodríguez, A., Zamora-Perez, A., Gómez-Meda, B.C., Ventura-Aguilar, A.J., Gallegos-Arreola, M.P., Spontaneous micronuclei in peripheral blood erythrocytes from 54 animal species (mammals, reptiles and birds): Part two (2000) Mutat. Res., 467, pp. 99-103 | ||
| 504 | |a Zuñiga, G., Torres-Bugarin, O., Ramos-Ibarra, M.L., Zamora-Pérez, A., Gómez-Meda, B.C., Ventura-Aguilar, A.J., Ramos, A., Gallegos-Arreola, M.P., Variation of micronucleated erythrocytes in peripheral blood of Sciurus aureogaster in relation to age: an increment of micronucleated polychromatic erythrocytes after the administration of colchicine (2001) Environ. Mol. Mutagen., 37, pp. 173-177 | ||
| 504 | |a Barnett, Y.A., King, C.M., An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans (1995) Mutat. Res., 338, pp. 115-128 | ||
| 504 | |a Rossi, D.J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., Weissman, I.L., Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age (2007) Nature, 447, pp. 725-729 | ||
| 504 | |a (2006) Genética Toxicológica, , De los Cuatro Vientos Editorial, Buenos Aires, Argentina, M.D. Mudry, M.A. Carballo (Eds.) | ||
| 504 | |a Poletta, L.G., Monitoreo de daño inducido por plaguicidas en Caiman latirostris (yacaré overo) como organismo centinela de los humedales de Argentina (2011) Tesis de Doctorado en Cs. Biológicas, , http://digital.bl.fcen.uba.ar/Download/Tesis/Tesis_4854_Poletta.pdf, FCEyN, UBA, Buenos Aires, Argentina | ||
| 504 | |a Islas-González, K., González-Hortal, C., Sánchez-Ramírez, B., Reyes-Aragón, E., Levario-Carrillo, M., In vitro assessment of the genotoxicity of ethyl paraoxon in newborns and adults (2005) Hum. Exp. Toxicol., 24, pp. 319-324 | ||
| 504 | |a Collins, A.R., Ai-guo, A., Duthie, S.J., The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells (1995) Mutat. Res., 336, pp. 69-77 | ||
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| 520 | 3 | |a Several studies indicate that certain factors such as age, sex or nutritional status among others, may affect the level of DNA damage, both induced and spontaneous, so it is very important to consider them for a more accurate interpretation of the findings. The aim of this study was to analyze the influence of age, sex, and nest of origin on spontaneous genetic damage of Tupinambis merianae determined by the comet assay (CA) and the micronucleus (MN) test, in order to improve reference data for future in vivo studies of xenobiotics exposure in this species. Sixty-five tegu lizards of three different ages: newborns (NB), juveniles (JUV) and adults (AD), both sexes and from different nests of origin were used. Blood samples were collected from the caudal vein of all animals and the MN test and CA were applied on peripheral blood erythrocytes to determine basal frequency of MN (BFMN) and basal damage index (BDI). The comparison between age groups showed statistically significant differences in the BFMN and BDI (p<0.05). NB animals showed significantly higher BDI values in relation to JUV and AD (p<0.016), but no statistically differences were found between the latter two. NB showed lower BFMN respect to other age groups, being statistically significant only when compared to AD (p<0.016). BFMN or BDI showed no statistically significant differences between sexes or nests of origin (p>0.05). A weak negative relationship was found only between BFMN and weight of NB tegu lizard (p=0.014; R2=0.245). Basal values of genetic damage obtained with both biomarkers in the tegu lizard evidenced that age is an intrinsic factor that should be taken into account to avoid misunderstanding of the results in future biomonitoring studies. © 2014 Elsevier B.V. |l eng | |
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, PICT 2011-1349 | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 2012-2014 CONICET | ||
| 536 | |a Detalles de la financiación: Secretaría de Ciencia y Técnica, Universidad de Buenos Aires, 01/W136 2011-2014 | ||
| 536 | |a Detalles de la financiación: This study was supported by Agencia Nacional de Promoción Científica y Tecnológica ( PICT 2011-1349 to GLP ), Consejo Nacional de Investigaciones Científicas y Técnicas ( PIP 2012-2014 CONICET to MDM ) and Universidad de Buenos Aires, Argentina ( UBACyT 01/W136 2011-2014 to MDM ). We would like to thank all members of Proyecto Iguana (Res. 031/07, Secretaria de Estado de Medio Ambiente y Desarrollo Sustentable de la Provincia de Santa Fe, Argentina) for their help in management and breeding activities. This study is part of LGS research as a doctoral fellow of CONICET in work collaboration between the UNL/MASPyMA and UBA-CONICET. Appendix A | ||
| 593 | |a Grupo de Investigación en Biología Evolutiva (GIBE), IEGEBA (CONICET-UBA), Labs. 43 y 46, Piso 4, FCEyN-Pabellón II-Cdad. Universitaria, Intendente Güiraldes 2160, CP: 1428EGA Buenos Aires, Argentina | ||
| 593 | |a Laboratorio Zoología Aplicada: Anexo Vertebrados (FHUC, UNL/MASPyMA), Aristóbulo del Valle 8700, (CP: 3000), Santa Fe, Argentina | ||
| 593 | |a Cátedra Toxicología, Farmacología y Bioquímica Legal (FBCB, UNL), Cuidad Universitaria Paraje El Pozo, Paraje El Pozo, (CP: 3000), Santa Fe, Argentina | ||
| 593 | |a Instituto de Ciencias Veterinarias del Litoral (ICiVet-CONICET), R.P. Kreder 2805, CP: S3080HOF Esperanza, Santa Fe, Argentina | ||
| 690 | 1 | 0 | |a AGE |
| 690 | 1 | 0 | |a BASAL GENETIC DAMAGE |
| 690 | 1 | 0 | |a COMET ASSAY |
| 690 | 1 | 0 | |a MICRONUCLEUS TEST |
| 690 | 1 | 0 | |a MONITORING |
| 690 | 1 | 0 | |a TEGU LIZARD |
| 690 | 1 | 0 | |a ADOLESCENT |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BASAL DAMAGE INDEX |
| 690 | 1 | 0 | |a BIRTH WEIGHT |
| 690 | 1 | 0 | |a BLOOD ANALYSIS |
| 690 | 1 | 0 | |a COMET ASSAY |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ERYTHROCYTE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENDER |
| 690 | 1 | 0 | |a GENETIC DAMAGE |
| 690 | 1 | 0 | |a GENETIC PARAMETERS |
| 690 | 1 | 0 | |a GROUPS BY AGE |
| 690 | 1 | 0 | |a LIZARD |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICRONUCLEUS |
| 690 | 1 | 0 | |a NEWBORN |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a TUPINAMBIS MERIANAE |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a SQUAMATA |
| 690 | 1 | 0 | |a TUPINAMBIS MERIANAE |
| 690 | 1 | 0 | |a TUPINAMBIS NIGROPUNCTATUS |
| 690 | 1 | 0 | |a AGE |
| 690 | 1 | 0 | |a BASAL GENETIC DAMAGE |
| 690 | 1 | 0 | |a COMET ASSAY |
| 690 | 1 | 0 | |a MICRONUCLEUS TEST |
| 690 | 1 | 0 | |a MONITORING |
| 690 | 1 | 0 | |a TEGU LIZARD |
| 690 | 1 | 0 | |a AGING |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ERYTHROBLASTS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a LIZARDS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICRONUCLEI, CHROMOSOME-DEFECTIVE |
| 700 | 1 | |a Poletta, G.L. | |
| 700 | 1 | |a Siroski, P.A. | |
| 700 | 1 | |a Mudry, M.D. | |
| 773 | 0 | |d Elsevier, 2014 |g v. 766 |h pp. 5-9 |p Mutat. Res. Genet. Toxicol. Environ. Mutagen. |x 13835718 |w (AR-BaUEN)CENRE-6178 |t Mutation Research - Genetic Toxicology and Environmental Mutagenesis | |
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