Predictors of myocardial tissue reperfusion after angioplasty in acute myocardial infarction

Background: The efficacy of primary angioplasty is limited due to the fact that a considerable number of patients do not achieve adequate levels of myocardial tissue perfusion. The degree of reperfusion depends on multiple clinical, angiographic and therapeutic factors. Objectives: To identify the i...

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Autor principal: Cura, F.A
Otros Autores: Escudero, A.G, Berrocal, D., Mendiz, O., Albertal, M., Baccaro, J., Trivi, M., Damonte, A., Thierer, J., Belardi, J.
Formato: Capítulo de libro
Lenguaje:Español
Publicado: 2009
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Acceso en línea:Registro en Scopus
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Registro en la Biblioteca Digital
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100 1 |a Cura, F.A. 
245 1 0 |a Predictors of myocardial tissue reperfusion after angioplasty in acute myocardial infarction 
246 3 1 |a Predictores de reperfusión miocárdica tisular luego de la angioplastia en el infarto agudo de miocardio 
260 |c 2009 
270 1 0 |m Cura, F. A.; Instituto Cardiovascular Buenos Aires, Blanco Encalada 1543, (1428) Buenos Aires, Argentina; email: fcura@icba-cardiovascular.com.ar 
506 |2 openaire  |e Política editorial 
504 |a Lincoff, A.M., Topol, E.J., Illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction? (1993) Circulation, 88, pp. 1361-1374 
504 |a Keeley, E.C., Boura, J.A., Grines, C.L., Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: A quantitative review of 23 randomised trials (2003) Lancet, 361, pp. 13-20 
504 |a Henriques, J.P., Zijlstra, F., Ottervanger, J.P., de Boer, M.J., van't Hof, A.W., Hoorntje, J.C., Incidence and clinical significance of distal embolization during primary angioplasty for acute myocardial infarction (2002) Eur Heart J, 23, pp. 1112-1117 
504 |a Cura, F.A., L'Allier, P.L., Kapadia, S.R., Houghtaling, P.L., Dipaola, L.M., Ellis, S.G., GUSTO IIb and RAPPORT Investigators. Predictors and prognosis of suboptimal coronary blood flow after primary coronary angioplasty in patients with acute myocardial infarction (2001) Am J Cardiol, 88, pp. 124-128 
504 |a Santoro, G.M., Valenti, R., Buonamici, P., Bolognese, L., Cerisano, G., Moschi, G., Relation between ST-segment changes and myocardial perfusion evaluated by myocardial contrast echocardiography in patients with acute myocardial infarction treated with direct angioplasty (1998) Am J Cardiol, 82, pp. 932-937 
504 |a De Luca, G., van 't Hof, A.W., de Boer, M.J., Ottervanger, J.P., Hoorntje, J.C., Gosselink, A.T., Time-to-treatment significantly affects the extent of ST-segment resolution and myocardial blush in patients with acute myocardial infarction treated by primary angioplasty (2004) Eur Heart J, 25, pp. 1009-1013 
504 |a A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators. N Engl J Med 1996;335:775-82; Schröder, R., Zeymer, U., Wegscheider, K., Neuhaus, K.L., Comparison of the predictive value of ST segment elevation resolution at 90 and 180 min after start of streptokinase in acute myocardial infarction. A substudy of the hirudin for improvement of thrombolysis (HIT)-4 study (1999) Eur Heart J, 20, pp. 1563-1571 
504 |a Dissmann, R., Schröder, R., Busse, U., Appel, M., Brüggemann, T., Jereczek, M., Early assessment of outcome by ST-segment analysis after thrombolytic therapy in acute myocardial infarction (1994) Am Heart J, 128, pp. 851-857 
504 |a Cura, F.A., Roffi, M., Pasca, N., Wolski, K.E., Lincoff, A.M., Topol, E.J., Global Use of Strategies to Open Occluded Arteries V Investigators. ST-segment resolution 60 minutes after combination treatment of abciximab with reteplase or reteplase alone for acute myocardial infarction (30-day mortality results from the resolution of ST-segment after reperfusion therapy substudy) (2004) Am J Cardiol, 94, pp. 859-863 
504 |a Cura, F.A., Escudero, A.G., Berrocal, D., Mendiz, O., Trivi, M.S., Fernandez, J., PREMIAR Investigators. Protection of Distal Embolization in High-Risk Patients with Acute ST-Segment Elevation Myocardial Infarction (PREMIAR) (2007) Am J Cardiol, 99, pp. 357-363 
504 |a Santoro, G.M., Antoniucci, D., Valenti, R., Bolognese, L., Buonamici, P., Trapani, M., Rapid reduction of ST-segment elevation after successful direct angioplasty in acute myocardial infarction (1997) Am J Cardiol, 80, pp. 685-689 
504 |a de Lemos JA, Antman EM, Giugliano RP, Morrow DA, McCabe CH, Cutler SS, et al. Comparison of a 60- versus 90-minute determination of ST-segment resolution after thrombolytic therapy for acute myocardial infarction. In TIME-II Investigators. Intravenous nPA for Treatment of Infarcting Myocardium Early-II. Am J Cardiol 2000;86:1235-7, A5; Ito, H., Okamura, A., Iwakura, K., Masuyama, T., Hori, M., Takiuchi, S., Myocardial perfusion patterns related to thrombolysis in myocardial infarction perfusion grades after coronary angioplasty in patients with acute anterior wall myocardial infarction (1996) Circulation, 93, pp. 1993-1999 
504 |a Berrocal, D., Belardi, J., Bazzino, O., Cagide, A., Doval, H.C., Rojas Matas, C., col, Fibrinolíticos versus angioplastia primaria en el infarto agudo de miocardio. (FAP). Estudio randomizado en un hospital de comunidad. (1996) Rev Argent Cardiol, 64, pp. 17-30 
504 |a Berrocal, D.H., Cohen, M.G., Spinetta, A.D., Ben, M.G., Rojas Matas, C.A., Gabay, J.M., Early reperfusion and late clinical outcomes in patients presenting with acute myocardial infarction randomly assigned to primary percutaneous coronary intervention or streptokinase (2003) Am Heart J, 146, pp. E22 
504 |a Angeja, B.G., Gunda, M., Murphy, S.A., Sobel, B.E., Rundle, A.C., Syed, M., TIMI myocardial perfusion grade and ST segment resolution: Association with infarct size as assessed by single photon emission computed tomography imaging (2002) Circulation, 105, pp. 282-285 
504 |a Guzman, E., Khan, I.A., Rahmatullah, S.I., Verghese, C., Yi, K.S., Niarchos, A.P., Resolution of ST-segment elevation after streptokinase therapy in anterior versus inferior wall myocardial infarction (2000) Clin Cardiol, 23, pp. 490-494 
504 |a Brener, S.J., Barr, L.A., Burchenal, J.E., Katz, S., George, B.S., Jones, A.A., Randomized, placebo-controlled trial of platelet glycoprotein IIb/IIIa blockade with primary angioplasty for acute myocardial infarction. ReoPro and Primary PTCA Organization and Randomized Trial (RAPPORT) Investigators (1998) Circulation, 98, pp. 734-741 
504 |a Neumann, F.J., Blasini, R., Schmitt, C., Alt, E., Dirschinger, J., Gawaz, M., Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction (1998) Circulation, 98, pp. 2695-2701 
504 |a Albertal, M., Cura, F., Escudero, A.G., Thierer, J., Trivi, M., Padilla, L.T., PREMIAR investigators. Mechanism involved in the paradoxical effects of active smoking following primary angioplasty: A subanalysis of the protection of distal embolization in high-risk patients with acute myocardial infarction trial (2008) J Cardiovasc Med (Hagerstown), 9, pp. 810-812 
504 |a Weisz, G., Cox, D.A., Garcia, E., Tcheng, J.E., Griffin, J.J., Guagliumi, G., Impact of smoking status on outcomes of primary coronary intervention for acute myocardial infarction- the smoker's paradox revisited (2005) Am Heart J, 150, pp. 358-364 
504 |a Ishihara, M., Sato, H., Tateishi, H., Kawagoe, T., Shimatani, Y., Kurisu, S., Clinical implications of cigarette smoking in acute myocardial infarction: Acute angiographic findings and long-term prognosis (1997) Am Heart J, 134, pp. 955-960 
504 |a Barbash, G.I., Reiner, J., White, H.D., Wilcox, R.G., Armstrong, P.W., Sadowski, Z., Evaluation of paradoxic beneficial effects of smoking in patients receiving thrombolytic therapy for acute myocardial infarction: Mechanism of the "smoker's paradox" from the GUSTOI trial, with angiographic insights. Global Utilization of Streptokinase and Tissue-Plasminogen Activator for Occluded Coronary Arteries (1995) J Am Coll Cardiol, 26, pp. 1222-1229 
504 |a Grines, C.L., Topol, E.J., O'Neill, W.W., George, B.S., Kereiakes, D., Phillips, H.R., Effect of cigarette smoking on outcome after thrombolytic therapy for myocardial infarction (1995) Circulation, 91, pp. 298-303 
520 3 |a Background: The efficacy of primary angioplasty is limited due to the fact that a considerable number of patients do not achieve adequate levels of myocardial tissue perfusion. The degree of reperfusion depends on multiple clinical, angiographic and therapeutic factors. Objectives: To identify the independent factors associated with the absence of myocardial tissue reperfusion after primary angioplasty. Material and Methods: A total of 140 patients included in the Protection of Distal Embolization in High-Risk Patients with Acute ST-Segment Elevation Myocardial Infarction Trial (PREMIAR) were analyzed. This study evaluated the use of filter distal protection device during angioplasty in patients with acute ST-segment elevation myocardial infarction at high risk of thrombosis (only including baseline TIMI grade 0-2 flow). The primary end point of the study was the rate of complete ST-segment resolution at 60 minutes, defined as ≥ 70% recovery compared with baseline during continuous ST-segment monitoring. A model of logistic regression was developed to identify independent predictors. Results: Complete resolution of ST-segment deviation 60 minutes after angioplasty was observed in 82 patients (63%), while 53 patients (37%) presented partial ST-segment resolution which was associated with rates of mortality, reinfarction and/or heart failure at 30 days of 8.5% and 18.9%, respectively (p=0.07). The variables associated with absence of adequate myocardial tissue reperfusion were anterior infarction (79% versus 33%; p=0.001), higher heart rate (81±20 versus 70±15; p=0.001) and history of current smoking (25% versus 51%; p=0.002), compared to optimal tissue reperfusion. In addition, there was a trend towards greater prevalence of diabetes (26% versus 16%; p=0.13), longer time interval from the onset of symptoms to angioplasty (minutes) (217±167 versus 182±134; p=0.19) and Killip class >1 (30% versus 17%; p=0.07), respectively. Multivariate analysis demonstrated that anterior myocardial infarction was associated with absence of complete reperfusion (OR 8.22, 95% CI 3.67-18.4; p<0.001), while the use of glycoprotein IIb/IIIa inhibitors (OR 4.21, 95% CI 1.34-13.22; p=0.014) and current smoking (OR 3.84, 95% CI 1.58-9.50; p=0.003) correlated with complete reperfusion. Conclusions: A considerable proportion of patients undergoing primary angioplasty do not achieve adequate myocardial tissue reperfusion. This phenomenon is associated with adverse outcomes. Anterior myocardial infarction correlates with less degree of tissue reperfusion. Conversely, current smoking and the use of glycoprotein IIb/IIIa inhibitors are associated with better tissue reperfusion after primary angioplasty.  |l eng 
593 |a Instituto Cardiovascular Buenos Aires, Blanco Encalada 1543, (1428) Buenos Aires, Argentina 
593 |a Hospital General de Agudos Dr. Cosme Argerich, Argentina 
593 |a Hospital Italiano de Buenos Aires, Argentina 
593 |a Fundación Favaloro, Argentina 
593 |a Instituto Cardiovascular de Corrientes, Argentina 
593 |a Instituto Cardiovascular de Rosario, Santa Fe, Argentina 
690 1 0 |a ANGIOPLASTY 
690 1 0 |a MYOCARDIAL INFARCTION 
690 1 0 |a MYOCARDIAL REPERFUSION 
690 1 0 |a FIBRINOGEN RECEPTOR ANTAGONIST 
690 1 0 |a ACUTE HEART INFARCTION 
690 1 0 |a ADULT 
690 1 0 |a AGED 
690 1 0 |a ANGIOPLASTY 
690 1 0 |a ARTICLE 
690 1 0 |a BLOOD FILTER 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DIABETES MELLITUS 
690 1 0 |a DRUG USE 
690 1 0 |a FEMALE 
690 1 0 |a HEART FAILURE 
690 1 0 |a HEART MUSCLE PERFUSION 
690 1 0 |a HEART RATE 
690 1 0 |a HEART REINFARCTION 
690 1 0 |a HUMAN 
690 1 0 |a MAJOR CLINICAL STUDY 
690 1 0 |a MALE 
690 1 0 |a MORTALITY 
690 1 0 |a PREDICTOR VARIABLE 
690 1 0 |a SMOKING 
690 1 0 |a ST SEGMENT ELEVATION 
690 1 0 |a THROMBOSIS 
653 0 0 |a SpideRX, ev3, United States 
700 1 |a Escudero, A.G. 
700 1 |a Berrocal, D. 
700 1 |a Mendiz, O. 
700 1 |a Albertal, M. 
700 1 |a Baccaro, J. 
700 1 |a Trivi, M. 
700 1 |a Damonte, A. 
700 1 |a Thierer, J. 
700 1 |a Belardi, J. 
773 0 |d 2009  |g v. 77  |h pp. 174-180  |k n. 3  |p Rev. Argent. Cardiol.  |x 00347000  |t Revista Argentina de Cardiologia 
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