α-RgIA: A novel conotoxin that specifically and potently blocks the α9α10 nAChR
The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits assemble to form the α9α10 nAChR subtype. This receptor is believed to mediate cholinergic synaptic transmission between efferent olivocochlear fibers and the hair cells of the cochlea. In addition α9 and/or α10 expression has been des...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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2006
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 12734caa a22015737a 4500 | ||
|---|---|---|---|
| 001 | PAPER-21868 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205322.0 | ||
| 008 | 190411s2006 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-32244443936 | |
| 024 | 7 | |2 Molecular Sequence Numbers |a GENBANK: DQ239610; | |
| 024 | 7 | |2 cas |a amino acid, 65072-01-7; alpha10 acetylcholine receptor, rat; Chrna9 protein, rat; conotoxin alpha-RgIA, Conus regius; Conotoxins; Protein Subunits; Receptors, Nicotinic | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BICHA | ||
| 100 | 1 | |a Ellison, M. | |
| 245 | 1 | 0 | |a α-RgIA: A novel conotoxin that specifically and potently blocks the α9α10 nAChR |
| 260 | |c 2006 | ||
| 270 | 1 | 0 | |m Ellison, M.; Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112-0840, United States; email: michael.ellison@m.cc.utah.edu |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Ellison, M., Gao, F., Wang, H.-L., Sine, S.M., Mcintosh, J.M., Olivera, B.M., α-conotoxins ImI and ImII target distinct regions of the human α7 nicotinic acetylcholine receptor and distinguish human nAChR subtypes (2004) Biochemistry, 43, pp. 16019-16026 | ||
| 520 | 3 | |a The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits assemble to form the α9α10 nAChR subtype. This receptor is believed to mediate cholinergic synaptic transmission between efferent olivocochlear fibers and the hair cells of the cochlea. In addition α9 and/or α10 expression has been described in dorsal root ganglion neurons, lymphocytes, skin keratinocytes, and the pars tuberalis of the pituitary. Specific antagonists that selectively block the α9α10 channel could be valuable tools for elucidating its role in these diverse tissues. This study describes a novel α-conotoxin from the Western Atlantic species Conus regius, α-conotoxin RgIA (α-RgIA), that is a subtype specific blocker of the α9α10 nAChR. α-RgIA belongs to the α4/3 subfamily of the α-conotoxin family; sequence and subtype specificity comparisons between α-RgIA and previously characterized α4/3 toxins indicate that the amino acids in the C-terminal half of α-RgIA are responsible for its preferential inhibition of the α9α10 nAChR subtype. © 2006 American Chemical Society. |l eng | |
| 593 | |a Department of Biology, University of Utah, Salt Lake City, UT 84112, United States | ||
| 593 | |a Department of Pathology, University of Utah, Salt Lake City, UT 84112, United States | ||
| 593 | |a Department of Psychiatry, University of Utah, Salt Lake City, UT 84112, United States | ||
| 593 | |a Instituto Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Buenos Aires 1428, Argentina | ||
| 593 | |a Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112-0840, United States | ||
| 690 | 1 | 0 | |a AMINO ACIDS |
| 690 | 1 | 0 | |a BIOCHEMISTRY |
| 690 | 1 | 0 | |a NEUROLOGY |
| 690 | 1 | 0 | |a SKIN |
| 690 | 1 | 0 | |a TISSUE |
| 690 | 1 | 0 | |a CONOTOXIN |
| 690 | 1 | 0 | |a DORSAL ROOT GANGLION NEURONS |
| 690 | 1 | 0 | |a LYMPHOCYTES |
| 690 | 1 | 0 | |a NICOTINIC ACETYLCHOLINE RECEPTOR (NACHR) |
| 690 | 1 | 0 | |a CELLS |
| 690 | 1 | 0 | |a ALPHA CONOTOXIN RGIA |
| 690 | 1 | 0 | |a ALPHA10 NICOTINIC RECEPTOR |
| 690 | 1 | 0 | |a ALPHA9 ALPHA10 NICOTINIC RECEPTOR |
| 690 | 1 | 0 | |a ALPHA9 NICOTINIC RECEPTOR |
| 690 | 1 | 0 | |a AMINO ACID |
| 690 | 1 | 0 | |a CONOTOXIN |
| 690 | 1 | 0 | |a NICOTINIC RECEPTOR |
| 690 | 1 | 0 | |a NICOTINIC RECEPTOR BLOCKING AGENT |
| 690 | 1 | 0 | |a RECEPTOR SUBTYPE |
| 690 | 1 | 0 | |a RECEPTOR SUBUNIT |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CARBOXY TERMINAL SEQUENCE |
| 690 | 1 | 0 | |a CHOLINERGIC TRANSMISSION |
| 690 | 1 | 0 | |a COCHLEA |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CONUS REGIUS |
| 690 | 1 | 0 | |a EFFERENT NERVE |
| 690 | 1 | 0 | |a HAIR CELL |
| 690 | 1 | 0 | |a HYPOPHYSIS PARS TUBERALIS |
| 690 | 1 | 0 | |a KERATINOCYTE |
| 690 | 1 | 0 | |a LYMPHOCYTE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN ASSEMBLY |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a RECEPTOR BLOCKING |
| 690 | 1 | 0 | |a SNAIL |
| 690 | 1 | 0 | |a SPINAL GANGLION |
| 690 | 1 | 0 | |a TOXIN STRUCTURE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BASE SEQUENCE |
| 690 | 1 | 0 | |a CLONING, MOLECULAR |
| 690 | 1 | 0 | |a CONOTOXINS |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION |
| 690 | 1 | 0 | |a HAIR CELLS, INNER |
| 690 | 1 | 0 | |a MOLECULAR SEQUENCE DATA |
| 690 | 1 | 0 | |a OOCYTES |
| 690 | 1 | 0 | |a POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a PROTEIN SUBUNITS |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a RECEPTORS, NICOTINIC |
| 690 | 1 | 0 | |a SPECIES SPECIFICITY |
| 690 | 1 | 0 | |a XENOPUS |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a CONUS REGIUS |
| 690 | 1 | 0 | |a GASTROPODA |
| 700 | 1 | |a Haberlandt, C. | |
| 700 | 1 | |a Gomez-Casati, M.E. | |
| 700 | 1 | |a Watkins, M. | |
| 700 | 1 | |a Elgoyhen, A.B. | |
| 700 | 1 | |a McIntosh, J.M. | |
| 700 | 1 | |a Olivera, B.M. | |
| 773 | 0 | |d 2006 |g v. 45 |h pp. 1511-1517 |k n. 5 |p Biochemistry |x 00062960 |w (AR-BaUEN)CENRE-755 |t Biochemistry | |
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| 856 | 4 | 0 | |u https://doi.org/10.1021/bi0520129 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00062960_v45_n5_p1511_Ellison |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062960_v45_n5_p1511_Ellison |y Registro en la Biblioteca Digital |
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| 963 | |a VARI | ||