Modulatory effects of leptin on leydig cell function of normal and hyperleptinemic rats
Neonatal L-monosodium glutamate (MSG) administration in rats induces several neuroendocrine and metabolic disruptions. Leptin, the adipocyte product, modulates several neuroendocrine systems including the hypothalamic-pituitary- gonadal (HPG) axis in mammals. The aim of the present study was to dete...
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2003
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| LEADER | 15384caa a22016457a 4500 | ||
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| 001 | PAPER-21382 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205250.0 | ||
| 008 | 190411s2003 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0344305654 | |
| 024 | 7 | |2 cas |a androstenedione, 26264-53-9, 63-05-8; chorionic gonadotropin, 9002-61-3; glutamate sodium, 142-47-2, 16177-21-2, 16690-92-9; hydroxyprogesterone, 68-96-2; testosterone, 58-22-0; androsta-5,16-dien-3 beta-ol, 1224-94-8; Androstenols; Follicle Stimulating Hormone, 9002-68-0; leptin receptor; Leptin; Luteinizing Hormone, 9002-67-9; Receptors, Cell Surface; RNA, Messenger; Sodium Glutamate, 142-47-2; Testosterone, 58-22-0; Thyroxine, 7488-70-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a NUNDA | ||
| 100 | 1 | |a Giovambattista, A. | |
| 245 | 1 | 0 | |a Modulatory effects of leptin on leydig cell function of normal and hyperleptinemic rats |
| 260 | |c 2003 | ||
| 270 | 1 | 0 | |m Calandra, R.S.; Inst. de Biol. y Med. Experimental, 1428 Buenos Aires, Argentina; email: direccion@imbice.org.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Giovambattista, A., Suescun, M.O., Aberer, J., Calandra, R.S., Spinedi, E., Differences in the pattern of circulating leptin between normal and hyperleptinemic rats over development (2003) Endocr Soc USA, p. 24. , abstr | ||
| 504 | |a Nemeroff, C.B., Konkol, R.J., Bissette, G., Younng-blood, W., Martin, J.B., Brazeau, P., Rone, M.S., Kizer, J.S., Analysis of the disruption in hypothalamic-pituitary regulation in rats treated neonatally with monosodium L-glutamate (MSG): Evidence for the involvement of tuberoinfundibular cholinergic and dopaminergic system in neuroendocrine regulation (1977) Endocrinology, 101, pp. 613-622 | ||
| 504 | |a Mendis-Handagama, S.M.L., Ariyaratne, H.B., Differentiation of adult Leydig cell population in the postnatal testis (2001) Biol Reprod, 65, pp. 660-671 | ||
| 504 | |a Nessralla, C.D.L., Giovambattista, A., Suescun, M.O., Calandra, R.S., Spinedi, E., Franca, L.R., Effects of leptin on the pituitary-testicular axis during testis development in rats (2003) Am Soc Andrology, , USA, abstr 101 | ||
| 504 | |a Chen, G.F., Ronis, M.J.J., Thomas, P.E., Flint, D.J., Badger, T.M., Hormonal regulation of microsomal cytochrome P450 2C11 in rat liver and kidney (1997) J Pharmacol Exp Ther, 283, pp. 1486-1494 | ||
| 504 | |a Shapiro, B.H., Pampori, N.A., Ram, P.A., Waxman, D.J., Irreversible suppression of growth hormone-dependent cytochrome P450 2C11 in adult rats neonatally treated with monosodium glutamate (1993) J Pharmacol Exp Ther, 265, pp. 979-984 | ||
| 504 | |a Pampori, N.A., Shapiro, B.H., Over-expression of CYP2C11, the major male-specific form of hepatic cytocrome P450, in the presence of nominal pulses of circulating growth hormone in adult male rats neonatally exposed to low levels of monosodium glutamate (1994) J Pharmacol Exp Ther, 271, pp. 1067-1073 | ||
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| 504 | |a Wabitsch, M., Ballauff, A., Holl, R., Blum, W.F., Heinze, E., Remschhmidt, H., Hedebrand, J., Serum leptin, gonadotropin, and testosterone concentrations in male patients with anorexia nervosa during weight gain (2001) J Clin Endocrinol Metab, 86, pp. 2982-2988 | ||
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| 504 | |a Ahima, R.S., Dushay, J., Flier, S.N., Prabakaran, D., Flier, J.S., Leptin accelerates the onset of puberty in normal female mice (1997) J Clin Invest, 99, pp. 391-395 | ||
| 504 | |a Suter, K.J., Pohl, C.R., Wilson, M.E., Circulating concentrations of nocturnal leptin, growth hormone, and insulin-like growth factor-I increase before the onset of puberty in agonadal male monkeys: Potential signals for the initiation puberty (2000) J Clin Endorinol Metab, 85, pp. 808-814 | ||
| 504 | |a Tena-Sempere, M., Pinilla, L., González, L.C., Casanueva, F.F., Dieguez, C., Aguilar, E., Homologous and heterologous down-regulation of leptin receptor messenger ribonucleic acid in rat adrenal gland (2000) J Endocrinol, 167, pp. 479-486 | ||
| 520 | 3 | |a Neonatal L-monosodium glutamate (MSG) administration in rats induces several neuroendocrine and metabolic disruptions. Leptin, the adipocyte product, modulates several neuroendocrine systems including the hypothalamic-pituitary- gonadal (HPG) axis in mammals. The aim of the present study was to determine whether MSG-induced chronic hyperleptinemia could play any relevant role in the hypogonadism developed by male rats when examined in adulthood. We found that 120-day-old MSG male rats displayed significant hyperleptinemia, hypogonadism, and undisturbed basic testis structure and spermatogenesis. In vitro studies in purified Leydig cells from normal (CTR) and MSG-damaged rats revealed that basal and human chorionic gonadotropin (hCG)-stimulated 17-hydroxy-progesterone (17-HO-P4,) Δ4-androstenedione (Δ 4A) and testosterone (T) secretions were significantly lower in MSG than in CTR cells. Exposure to murine leptin (mleptin, 10-8 M) significantly inhibited hCG-elicited T secretion by CTR cells after 180 min incubation. While mleptin significantly inhibited hCG-stimulated Δ 4A output and the Δ4A:17-OH-P4 ratio of secretion, conversely, it failed to modify the ratio T:Δ4A release by CTR Leydig cells. Interestingly, the effects of mleptin found on CTR Leydig cells were absent in MSG Leydig cells. Finally, endogenous hyperleptinemia was associated with a significant decrease in Leydig cell expression of Ob-Rb mRNA in MSG rats. In summary, this study demonstrates that: (1) mleptin inhibited testicular steroidogenesis in CTR rats; (2) MSG-treated rats showed lower in vitro 17-OH-P4, Δ4A and T production under basal and post-hCG stimulation conditions; (3) purified Leydig cells from MSG-treated rats displayed resistance to the inhibitory action of mleptin on T release, and (4) endogenous leptin exerts a modulatory effect on Leydig cell Ob-Rb mRNA expression. The inhibitory effect of leptin on testicular function is thus abrogated in MSG-damaged rats. The testicular leptin-resistance developed by MSG rats seems to be due to early chronic exposure of Leydig cells to high leptin circulating levels, which in turn down-regulate testicular Ob-Rb expression. It remains to be determined whether the testicular dysfunction of MSG rats can be reversed after correction of hyperleptinemia or whether it is an irreversible effect of the hypothalamic lesion. Copyright © 2003 S. Karger AG, Basel. |l eng | |
| 593 | |a Inst. Multidisciplinario Biol. Cel., La Plata, Argentina | ||
| 593 | |a Facultad de Ciencias Exactas, UNLP, La Plata, Argentina | ||
| 593 | |a Laboratory of Cell Biology, Federal University of Minas Gerais, Belo Horizonte, Brazil | ||
| 593 | |a Inst. de Biol. y Med. Experimental, Buenos Aires, Argentina | ||
| 593 | |a Inst. de Biol. y Med. Experimental, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a GONADAL STEROIDS |
| 690 | 1 | 0 | |a HYPOGONADISM |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a LEYDIG CELLS |
| 690 | 1 | 0 | |a MONOSODIUM GLUTAMATE |
| 690 | 1 | 0 | |a STEROIDOGENESIS |
| 690 | 1 | 0 | |a TESTIS |
| 690 | 1 | 0 | |a ANDROSTENEDIONE |
| 690 | 1 | 0 | |a CHORIONIC GONADOTROPIN |
| 690 | 1 | 0 | |a GLUTAMATE SODIUM |
| 690 | 1 | 0 | |a HYDROXYPROGESTERONE |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL FUNCTION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HORMONE RELEASE |
| 690 | 1 | 0 | |a HYPERLEPTINEMIA |
| 690 | 1 | 0 | |a HYPOGONADISM |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a LEYDIG CELL |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NEUROENDOCRINE DISEASE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SPERMATOGENESIS |
| 690 | 1 | 0 | |a STEROIDOGENESIS |
| 690 | 1 | 0 | |a TESTIS |
| 690 | 1 | 0 | |a TESTOSTERONE RELEASE |
| 690 | 1 | 0 | |a ANALYSIS OF VARIANCE |
| 690 | 1 | 0 | |a ANDROSTENOLS |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANIMALS, NEWBORN |
| 690 | 1 | 0 | |a BLOTTING, NORTHERN |
| 690 | 1 | 0 | |a BODY WEIGHT |
| 690 | 1 | 0 | |a DISEASE MODELS, ANIMAL |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FOLLICLE STIMULATING HORMONE |
| 690 | 1 | 0 | |a HYPOGONADISM |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a LEYDIG CELLS |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a ORGAN SIZE |
| 690 | 1 | 0 | |a RADIOIMMUNOASSAY |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a RECEPTORS, CELL SURFACE |
| 690 | 1 | 0 | |a REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a RNA, MESSENGER |
| 690 | 1 | 0 | |a SODIUM GLUTAMATE |
| 690 | 1 | 0 | |a TESTIS |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 690 | 1 | 0 | |a THYROXINE |
| 700 | 1 | |a Suescun, M.O. | |
| 700 | 1 | |a Nessralla, C.C.D.L. | |
| 700 | 1 | |a França, L.R. | |
| 700 | 1 | |a Spinedi, E. | |
| 700 | 1 | |a Calandra, R.S. | |
| 773 | 0 | |d 2003 |g v. 78 |h pp. 270-279 |k n. 5 |p Neuroendocrinology |x 00283835 |w (AR-BaUEN)CENRE-6253 |t Neuroendocrinology | |
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