Regulation of HLA-DR antigen in monocytes from colorectal cancer patients by in vitro treatment with human recombinant interferon-γ
During the immune response, a great number of cytokines that modulate the function of mononuclear phagocytes are produced. Since interferons are one of the most important cytokines, the aim of this study was to evaluate the expression of HLA-DR antigen after an 18-h culture with human recombinant in...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2000
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
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| LEADER | 09211caa a22009857a 4500 | ||
|---|---|---|---|
| 001 | PAPER-20950 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205223.0 | ||
| 008 | 190411s2000 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0034068786 | |
| 024 | 7 | |2 cas |a Antigens, Neoplasm; HLA-DR Antigens; Interferon-gamma, Recombinant | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JIAIE | ||
| 100 | 1 | |a Novellino, P.S. | |
| 245 | 1 | 0 | |a Regulation of HLA-DR antigen in monocytes from colorectal cancer patients by in vitro treatment with human recombinant interferon-γ |
| 260 | |c 2000 | ||
| 270 | 1 | 0 | |m Rumi, L.S.; Inst. Biologia Medicina Experimental, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Farrar, M.A., Schreiber, R.D., The molecular cell biology of interferon-γ and its receptor (1993) Annu Rev Immunol, 11, pp. 571-611 | ||
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| 504 | |a Virelizier, J.L., Pérez, N., Arenzana Seisdedos, F., Devos, R., Pure interferon gamma enhances class II HLA antigens on human monocyte cell lines (1984) J Immunol, 14, pp. 106-108 | ||
| 504 | |a Volk, H.D., Gruner, S., Falck, P., Von Baehr, R., The influence of interferon-γ and various phagocytic stimuli on the expression of MHC-class II antigens on human monocytes - Relation to the generation of reactive oxigen intermediates (1986) Immunol Lett, 13, pp. 209-214 | ||
| 504 | |a Koeffer, H., Raynard, J., Yelton, L., Gamma interferon induces expression of HLA-D antigens on normal and leukaemic human myeloid cells (1984) Proc Natl Acad Sci USA, 81, p. 4080 | ||
| 504 | |a Ghosh, A., Cerny, T., Wagstaff, J., Effect of in vivo administration of interferon gamma on expression of MHC products and tumor associated antigens in patients with metastatic melanoma (1989) Eur J Cancer Clin Oncol, 25, p. 1637 | ||
| 504 | |a Snyder, D., Beller, D., Unanue, E., Prostaglandins modulate macrophage la expression (1982) Nature, 299, p. 163 | ||
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| 504 | |a Novellino, P.S., Trejo, Y.G., Fernández, O., Bordenave, R.H., Rumi, L.S., Relación entre la expresión de HLA-DR de superficie y reduction del NBT en monocitos de pacientes con cancer colorectal (1991) Sangre, 36, p. 99 | ||
| 504 | |a Lee, Y.J., Han, Y., Lu, H.T., Nguyen, V., Qin, H., Howe, P.H., Hocevar, B.A., Benveniste, E.N., TGF-β suppresses IFN-γ induction of class II gene expression by inhibiting class II transactivator messenger RNA expression (1997) J Immunol, 158 (5), pp. 2065-2075 | ||
| 504 | |a Nandan, D., Reiner, N.E., TGF-β attenuates the class II transactivator and reveals an accesory pathway of IFN-γ action (1997) J Immunol, 158 (3), pp. 1095-1101 | ||
| 504 | |a Koppelman, B., Neefjes, J.J., De Vries, J.E., De Waal-Malefyt, R., Interleukin-10 down-regulates MHC class II alpha-beta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling (1997) Immunity, 7, pp. 861-871 | ||
| 504 | |a Baron, S., Tyring, S.K., Fleischmann, W.R., Coppenhaver, D.H., Niesel, D.W., Klimpel, G.R., Stanton, J., Hughes, T.K., The interferons: Mechanisms of action and clinical implications (1991) JAMA, 266 (10), pp. 1375-1383 | ||
| 504 | |a Sicher, S.C., Chung, G.W., Vázquez, M.A., Lu, C.Y., Augmentation or inhibition of IFN-γ-induced MHC class II expression by lipopolysaccharides. The roles of TNF-γ and nitric oxide, and the importance of the sequence signaling (1995) J Immunol, 155 (12), pp. 5826-5834 | ||
| 504 | |a Sztein, M.B., Steeg, P.S., Johnson, H.M., Regulation of human peripheral blood monocyte DR antigen expression in vitro by lymphokines and recombinant interferons (1984) J Clin Invest, 73, pp. 556-565 | ||
| 504 | |a Leeuwenberg, J.F., Von Asmuth, E.J., Jeunhomme, T.M., Buurman, W.A., IFN-γ regulates the expression of adhesion molecule ELAM-1 and IL-6 production by human endothelial cells (1990) J Immunol, 145, pp. 2110-2114 | ||
| 504 | |a Barker, J.N.W.N., Sarma, V., Mitra, R.S., Dixit, V.M., Nickoloff, B.J., Marked synergism between tumor necrosis factor-γ and interferon-γ in regulation of keratinocyte-derived adhesion molecules and chemotactic factors (1990) J Clin Invest, 85, pp. 605-608 | ||
| 504 | |a Matsushita, K., Takenouchi, T., Kobayashi, S., Hayashi, H., Okuyama, K., Ochiai, T., Mikata, A., Isono, K., HLA-DR antigen expression on colorectal carcinomas: Influence of expression by IFN-γ in situ and its association with tumour progression (1996) Br J Cancer, 73 (5), pp. 644-648 | ||
| 504 | |a Koshiji, M., Aadachi, Y., Sogo, S., Taketani, S., Oyaizu, N., Than, S., Inaba, M., Ikehara, S., Apoptosis of colorectal adenocarcinoma (COLO201) by tumor necrosis factor-alpha (TNF-α) and/or interferon-gamma (IFN-γ) resulting from down-modulation of Bcl-2 expression (1998) Clin Exp Immunol, 111 (1), pp. 211-218 | ||
| 504 | |a Munker, R., Andreeff, M., Induction of death (CD/95/Fas), activation and adhesion (CD54) molecules on blast cells of acute myelogenous leukaemias by TNF-α and IFN-γ (1996) Cytokines Mol Ther, 2 (3), pp. 147-162 | ||
| 520 | 3 | |a During the immune response, a great number of cytokines that modulate the function of mononuclear phagocytes are produced. Since interferons are one of the most important cytokines, the aim of this study was to evaluate the expression of HLA-DR antigen after an 18-h culture with human recombinant interferon-γ (hrIFN-γ) on freshly isolated peripheral blood monocytes from 16 colorectal cancer patients and 16 healthy donors, using an indirect immunofluorescence method. The results obtained showed that there was a decreased percentage of HLA-DR+ monocytes in the colorectal cancer patents (51 ± 3%, p < 0.01) compared with the healthy donors (77 ± 2%). Treatment for 18 h with hrIFN-γ increased the percentages of monocytes expressing HLA-DR: 71 ± 3% for the cancer patients and 84 ± 2% for the healthy donors (p < 0.01 and < 0.001, respectively). Our results demonstrate that after in vitro treatment with hrIFN-γ, functionally altered monocytes from colorectal cancer patients can reach major histocompatibility complex II antigen expression values similar to those of healthy donors, thus improving the host's cellular immune response against the tumor. |l eng | |
| 593 | |a Immunology Laboratory, Inst. de Biol. y Med. Exp. (IByME), Buenos Aires, Argentina | ||
| 593 | |a Hospital de Agudos Iriarte, Buenos Aires, Argentina | ||
| 593 | |a Inst. de Biol. y Med. Experimental, Vuelta de Obligado 2490, (1428) Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a COLORECTAL CANCER |
| 690 | 1 | 0 | |a HLA-DR |
| 690 | 1 | 0 | |a INTERFERON-Γ |
| 690 | 1 | 0 | |a MONOCYTES |
| 690 | 1 | 0 | |a CYTOKINE |
| 690 | 1 | 0 | |a HLA DR ANTIGEN |
| 690 | 1 | 0 | |a MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2 |
| 690 | 1 | 0 | |a RECOMBINANT GAMMA INTERFERON |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELLULAR IMMUNITY |
| 690 | 1 | 0 | |a CLINICAL ARTICLE |
| 690 | 1 | 0 | |a COLORECTAL CANCER |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOKINE PRODUCTION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a IMMUNE RESPONSE |
| 690 | 1 | 0 | |a IMMUNOFLUORESCENCE |
| 690 | 1 | 0 | |a LEUKOCYTE CULTURE |
| 690 | 1 | 0 | |a MONOCYTE |
| 690 | 1 | 0 | |a MONONUCLEAR PHAGOCYTE |
| 690 | 1 | 0 | |a TUMOR IMMUNITY |
| 690 | 1 | 0 | |a ADENOCARCINOMA |
| 690 | 1 | 0 | |a ANTIGENS, NEOPLASM |
| 690 | 1 | 0 | |a COLORECTAL NEOPLASMS |
| 690 | 1 | 0 | |a FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION, NEOPLASTIC |
| 690 | 1 | 0 | |a HLA-DR ANTIGENS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a INTERFERON-GAMMA, RECOMBINANT |
| 690 | 1 | 0 | |a LEUKOCYTES, MONONUCLEAR |
| 700 | 1 | |a Trejo, Y.G. | |
| 700 | 1 | |a Beviacqua, M. | |
| 700 | 1 | |a Bordenave, R.H. | |
| 700 | 1 | |a Rumi, L.S. | |
| 773 | 0 | |d 2000 |g v. 10 |h pp. 90-93 |k n. 2 |p J. Invest. Allergol. Clin. Immunol. |x 10189068 |w (AR-BaUEN)CENRE-7594 |t Journal of Investigational Allergology and Clinical Immunology | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_10189068_v10_n2_p90_Novellino |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10189068_v10_n2_p90_Novellino |y Registro en la Biblioteca Digital |
| 961 | |a paper_10189068_v10_n2_p90_Novellino |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||