Photodynamic therapy of activated and resting lymphocytes and its antioxidant adaptive response
In this work we have studied the effects of ALA-mediated photodynamic therapy (PDT) on resting and mitogen-activated murine splenic lymphocytes, evaluating its impact on cell viability. We have also characterised the stress response, measuring the levels of antioxidant enzymes. A 2 h exposure to ALA...
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Springer London
2002
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| LEADER | 09213caa a22007697a 4500 | ||
|---|---|---|---|
| 001 | PAPER-20478 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205153.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0036173087 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a LMSCE | ||
| 100 | 1 | |a Casas, A. | |
| 245 | 1 | 0 | |a Photodynamic therapy of activated and resting lymphocytes and its antioxidant adaptive response |
| 260 | |b Springer London |c 2002 | ||
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Sieber, F., Spivak, J., Sutcliffe, A., Selective killing of leukemic cells by merocyanine 540-mediated photosensitization (1984) Proc Natl Acad Sci USA, 81, pp. 7584-7587 | ||
| 504 | |a Malik, Z., Lugaci, H., Destruction of erythroleukemic cells by photoactivation of endogenous porphyrins (1987) Br J Cancer, 56, pp. 589-595 | ||
| 504 | |a Grebenova, D., Cajthamlova, H., Bartosova, J., Marinov, J., Klamova, H., Selective destruction of leukaemic cells by photo-activation of 5-aminolaevulinic acid-induced protoporphyrin-IX (1998) J Photochem Photobiol B, 47, pp. 74-81 | ||
| 504 | |a Hryhorenko, E., Rittenhouse-Diakun, K., Harvey, N., Morgan, J., Stewart, C., Oseroff, A., Characterization of endogenous protoporphyrin IX induced by 5-aminolevulinic acid in resting and activated peripheral blood lymphocytes by four-color flow cytometry (1998) Photochem Photobiol, 67, pp. 565-572 | ||
| 504 | |a Rittenhouse-Diakun, K., Van Leengoed, H., Morgan, J., Hryhorenko, E., Paszkiewicz, J., Whitaker, J., The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor 5-aminolevulinic acid (ALA) (1995) Photochem Photobiol, 61, pp. 523-528 | ||
| 504 | |a Wolf, P., Fink-Puches, R., Cerroni, L., Kerl, H., Photodynamic therapy for mycosis fungoides after topical photosensitization with 5-aminolevulinic acid (1994) J Am Acad Dermatol, 31, pp. 678-680 | ||
| 504 | |a Gulati, S., Atzpodien, J., Lemoli, R., Shimazaki, C., Clarkson, B., Photoradiation methods for purging autologous bone marrow grafts (1990) Bone Marrow Purging and Processing, pp. 87-102. , Doiron H., Gomer C. J. (eds) New York: Alan R. Liss | ||
| 504 | |a Lemoli, R., Igarashi, T., Knizevski, M., Acaba, L., Ritcher, A., Jain, A., Dye-mediated photolysis is capable of eliminating drug-resistant (MDR+) tumor cells (1993) Blood, 81, pp. 793-800 | ||
| 504 | |a Singer, C., Bown, S., Linch, D., Huehns, E., Goldstone, A., Phthalocyanine photosensitization for in vitro elimination of residual acute non-lymphoblastic leukemia: Preliminary evaluation (1987) Photochem Photobiol, 46, pp. 745-749 | ||
| 504 | |a Sieber, F., Krueger, G., Photodynamic therapy and bone marrow transplantation (1989) Semin Hematol, 26, pp. 35-39 | ||
| 504 | |a Grebenova, D., Cajthamlova, H., Holanda, K., Marinov, J., Jirsa, M., Hrkal, Z., Photodynamic effects of meso-tetra (4-sulfonatophenyl) porphine on human leukemia cells HEL and HL60, human lymphocytes and bone marrow progenitor cells (1997) J Photochem Photobiol B, 39, pp. 269-278 | ||
| 504 | |a Kehrer, J., Free radicals as mediators of tissue injury and disease (1993) Crit Rev Toxicol, 23, pp. 21-48 | ||
| 504 | |a Meister, A., Selective modification of glutathione metabolism (1983) Science, 220, pp. 470-477 | ||
| 504 | |a Alvarez, S., Boveris, A., Induction of antioxidant enzymes and DT-diaphorase in human blood mononuclear cells by light stress (1993) Arch Biochem Biophys, 305, pp. 247-251 | ||
| 504 | |a Alvarez, S., Boveris, A., Antioxidant adaptive response in human blood mononuclear cells exposed to UVB (1997) J Photochem Photobiol, 38, pp. 152-157 | ||
| 504 | |a Denizot, F., Lang, R., Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability (1986) J Immunol Methods, 89, pp. 271-277 | ||
| 504 | |a Paoletti, F., Aldinucci, D., Mocali, A., Caparrini, A., A sensitive spectrophotomeric method for the determination of superoxide dismutase activity in tissue extracts (1986) Anal Biochem, 154, pp. 536-541 | ||
| 504 | |a Flohe, L., Gunzler, W., Assays of glutathione peroxidase (1984) Methods Enzymol, 105, pp. 114-121 | ||
| 504 | |a Aebi, H., Catalase in vitro (1984) Methods Enzymol, 105, pp. 121-126 | ||
| 504 | |a Lowry, O., Rosebrough, N., Farr, L., Randall, R., Protein measurement with the phenol reagent (1951) J Biol Chem, 219, pp. 435-437 | ||
| 504 | |a Hissin, P., Hilf, R., A fluorometric method for determination of oxidized and reduced glutathione in tissues (1976) Anal Biochem, 74, pp. 214-226 | ||
| 504 | |a Eléouet, S., Carré, J., Vonarx, V., Heyman, D., Lajat, D.Y., Patrice, T., Delta-aminolevulinic acid-induced fluorescence in normal human lymphocytes (1997) J Photochem Photobiol, 41, pp. 22-29 | ||
| 504 | |a Hiraku, Y., Kawanishi, S., Mechanism of oxidative DNA damage induced by delta-aminolevulinic acid in the presence of copper ion (1996) Cancer Res, 56, pp. 1786-1793 | ||
| 504 | |a Princ, F., Juknat, A., Amitrano, A., Batlle, A., Effect of reactive oxygen species promoted by deltaaminolevulinic acid on porphyrin biosynthesis and glucose uptake in rat cerebellum (1998) Gen Pharmacol, 31, pp. 143-148 | ||
| 504 | |a Cohen, G., Hochstein, P., Glutathione peroxidase: The primary agent for the elimination of hydrogen peroxide in erythrocytes (1963) Biochemistry, 2, pp. 1420-1428 | ||
| 504 | |a Rittenhouse-Diakun, K., Van Leengoed, H., Morgan, J., Hryhorenko, E., Paszkiewicz, J., Whitaker, J., The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor 5-aminolevulinic acid (ALA) (1995) Photochem Photobiol, 61, pp. 523-528 | ||
| 504 | |a Hryhorenko, E., Oseroff, A., Morgan, J., Rittenhouse-Diakun, K., Deletion of alloantigen-activated cells by aminolevulinic acid-based photodynamic therapy (1999) Photochem Photobiol, 69, pp. 560-565 | ||
| 504 | |a Demasi, M., Costa, C., Pascual, C., Llesuy, S., Bechara, E., Oxidative tissue response promoted by 5-aminolevulinic acid promptly induces the increase of plasma antioxidant capacity (1997) Free Radic Res, 26, pp. 235-243 | ||
| 504 | |a Williams, M., Krootjes, B., Van Steveninck, J., Van der Zee, J., The pro- and antioxidant properties of proto-porphyrin IX (1999) Biochim Biophys Acta, 1211, pp. 310-316 | ||
| 504 | |a Michiels, C., Raes, M., Touissant, O., Renacle, J., Importance of Se-glutathione peroxidase, catalase, and SOD Cu/Zn for cell survival against oxidative stress (1994) Free Radical Biol Med, 17, pp. 235-248 | ||
| 520 | 3 | |a In this work we have studied the effects of ALA-mediated photodynamic therapy (PDT) on resting and mitogen-activated murine splenic lymphocytes, evaluating its impact on cell viability. We have also characterised the stress response, measuring the levels of antioxidant enzymes. A 2 h exposure to ALA produced 50% lethality upon irradiation of activated cells with 2.1 J/cm2. The decrease in cell survival with increasing time exposure to ALA, correlated well with the higher porphyrin accumulation. In resting lymphocytes, in spite of the low amount of porphyrins formed during 2 h incubation with ALA, 40% of the cells died after irradiation, this response was not further increased when higher amounts of porphyrins were synthesised. Superoxide dismutase was impaired by light treatment independently of ALA exposure in activated lymphocytes and, to a lesser extent, in resting lymphocytes. PDT induced an antioxidant adaptive response in activated cells 19 h after irradiation, reflected as a net increase in GSHPx activity and a slight reversion of the catalase (CAT) activity already impaired by light treatment. PDT treatment of activated cells also produced a diminution in the GSH/GSSG ratio. Only activated cells are capable of developing an antioxidant adaptive response to PDT treatment. |l eng | |
| 593 | |a Centro de Investigaciones sobre Porfirinas y Porfirias, FCEyN, University of Buenos Aires, CONICET Ciudad Universitaria, Capital Federal, Argentina | ||
| 690 | 1 | 0 | |a 5-AMINOLAEVULINIC ACID |
| 690 | 1 | 0 | |a CATALASE |
| 690 | 1 | 0 | |a GLUTATHIONE PEROXIDASE |
| 690 | 1 | 0 | |a LYMPHOCYTES |
| 690 | 1 | 0 | |a PDT |
| 690 | 1 | 0 | |a PHOTODYNAMIC THERAPY |
| 690 | 1 | 0 | |a SUPEROXIDE DISMUTASE |
| 700 | 1 | |a Perotti, C. | |
| 700 | 1 | |a Fukuda, H. | |
| 700 | 1 | |a del, A.M. | |
| 700 | 1 | |a Batlle, C. | |
| 773 | 0 | |d Springer London, 2002 |g v. 17 |h pp. 42-50 |k n. 1 |p Lasers Med. Sci. |x 02688921 |t Lasers in Medical Science | |
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| 856 | 4 | 0 | |u https://doi.org/10.1007/s10103-002-8265-6 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_02688921_v17_n1_p42_Casas |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02688921_v17_n1_p42_Casas |y Registro en la Biblioteca Digital |
| 961 | |a paper_02688921_v17_n1_p42_Casas |b paper |c PE | ||
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| 999 | |c 81431 | ||