Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes

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Amphiphilic phthalocyanines are used as potential photosensitizers in photodynamic therapy. The low water solubility of most of these dyes is the reason that different kinds of vehicles are employed as endogenous carriers. Due to the photophysical inactivity of the phthalocyanine aggregates, it is i...

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Detalles Bibliográficos
Autor principal: Rodriguez, M.E
Otros Autores: Awruch, J., Dicelio, L.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Society of Porphyrins and Phthalocyanines (SPP) 2002
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-0036355413 
024 7 |2 cas  |a dimyristoylphosphatidylcholine, 13699-48-4, 18194-24-6 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a JPPHF 
100 1 |a Rodriguez, M.E. 
245 1 0 |a Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes 
260 |b Society of Porphyrins and Phthalocyanines (SPP)  |c 2002 
270 1 0 |m Dicelio, L.; INQUIMAE, Departamento de Quimica Inorganica, Universidad de Buenos Aires, Ciudad Universitaria, (1428) Buenos Aires, Argentina; email: led@qi.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
504 |a Allen, C.M., Sharman, W.M., Van Lier, J.E., (2001) J. Porphyrins Phthalocyanines, 5, pp. 161-169 
504 |a Aveline, B.M., Hasan, T., Redmond, R.W., (1995) J. Photochem. Photobiol., B, 30, pp. 161-169 
504 |a Fernandez, D.A., Awruch, J., Dicelio, L.E., (1996) Photochem. Photobiol., 63, pp. 784-792 
504 |a Macdonald, I.J., Dougherty, T.J., (2001) J. Porphyrins Phthalocyanines, 5, pp. 105-129 
504 |a Bennett, L.E., Ghiggino, K.P., Henderson, R.W., (1989) J. Photochem. Photobiol., B, 3, pp. 81-89 
504 |a Woodburn, K., Chang, C.K., Lee, S., Henderson, B., Kessel, D., (1994) Photochem. Photobiol., 60, pp. 154-159 
504 |a Wiehe, A., Simonenko, E.J., Senge, M.O., Roder, B., (2001) J. Porphyrins Phthalocyanines, 5, pp. 758-761 
504 |a Fernandez, D.A., Dicelio, L.E., Awruch, J., (1995) J. Heterocycl. Chem., 32, pp. 519-522 
504 |a Fernandez, D.A., Awruch, J., Dicelio, L.E., (1997) J. Photochem. Photobiol., B, 41, pp. 227-232 
504 |a Gaspard, S., Maillard, P., (1987) Tetrahedron, 43, pp. 1083-1090 
504 |a Kremer, J.M.H., Van der Esker, M.W., Pathmamanoharan, C., Wiersema, P.H., (1977) Biochemistry, 16, pp. 3932-3935 
504 |a Kuzelova, K., Brault, D., (1994) Biochemistry, 33, pp. 9447-9459 
504 |a Gabriela Lagorio, M., Dicelio, L.E., Roman, E.S., (1993) J. Photochem. Photobiol., A, 72, pp. 153-161 
504 |a Darwent, J.R., Douglas, P., Harriman, A., Porter, G., Richoux, M.C., (1982) Coord. Chem. Rev., 44, pp. 83-126 
504 |a Lakowicz, J.R., (1986) Principles of Fluorescence Spectroscopy; 2nd ed., pp. 237-263. , Plenum Press: New York 
504 |a Ricchelli, F., Jori, G., Gobbo, S., Tronchin, M., (1991) Biochim. Biophys. Acta, 1065, pp. 42-48 
504 |a Margalit, R., Cohen, S., (1983) Biochim. Biophys. Acta, 736, pp. 163-170 
504 |a Angeli, N.G., Lagorio, M.G., Roman, E.A.S., Dicelio, L.E., (2000) Photochem. Photobiol., 72, pp. 49-56 
504 |a Ricchelli, F., Jori, G., Moreno, G., Vinzens, F., Salet, C., (1990) J. Photochem. Photobiol., B, 6, pp. 69-77 
520 3 |a Amphiphilic phthalocyanines are used as potential photosensitizers in photodynamic therapy. The low water solubility of most of these dyes is the reason that different kinds of vehicles are employed as endogenous carriers. Due to the photophysical inactivity of the phthalocyanine aggregates, it is important to improve their solubility in order to study dyes in solid tumor models. On the other hand, the photodynamic therapy activity depends on the location of phthalocyanines in the cell and the interaction of cellular components. In this work, the photophysical properties of tetrasubstituted Zn(II) phthalocyanines with different lipophilic properties are incorporated into liposomes of L-α-dimyristoylphosphatidylcholine (DMPC). The fluorescence quantum yields, the association constants and their localization in the membranes are reported. Copyright © 2002 Society of Porphyrins & Phthalocyanines.  |l eng 
593 |a INQUIMAE, Departamento de Quimica Inorganica, Universidad de Buenos Aires, Ciudad Universitaria, (1428) Buenos Aires, Argentina 
690 1 0 |a ASSOCIATION CONSTANT 
690 1 0 |a FLUORESCENCE QUANTUM YIELDS 
690 1 0 |a LIPOSOMES 
690 1 0 |a PDT 
690 1 0 |a ZINC PHTHALOCYANINE 
690 1 0 |a DIMYRISTOYLPHOSPHATIDYLCHOLINE 
690 1 0 |a LIPOSOME 
690 1 0 |a PHOTOSENSITIZING AGENT 
690 1 0 |a PHTHALOCYANINE DERIVATIVE 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a ZINC DERIVATIVE 
690 1 0 |a ZINC PHTHALOCYANINATE 
690 1 0 |a ARTICLE 
690 1 0 |a BINDING AFFINITY 
690 1 0 |a CHEMICAL STRUCTURE 
690 1 0 |a DRUG SOLUBILITY 
690 1 0 |a FLUORESCENCE SPECTROSCOPY 
690 1 0 |a LIPOPHILICITY 
690 1 0 |a PHOTODYNAMIC THERAPY 
700 1 |a Awruch, J. 
700 1 |a Dicelio, L. 
773 0 |d Society of Porphyrins and Phthalocyanines (SPP), 2002  |g v. 6  |h pp. 122-129  |k n. 2  |p J. Porphyrins Phthalocyanines  |x 10884246  |t Journal of Porphyrins and Phthalocyanines 
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856 4 0 |u https://doi.org/10.1142/S1088424602000166  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_10884246_v6_n2_p122_Rodriguez  |y Handle 
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