Trypanosoma cruzi: Antibodies to a MAP-like protein in chronic chagas' disease cross-react with mammalian cytoskeleton
Trypanosoma cruzi λgtll library from epimastogote derived mRNA was screened with human chagasic sera or sera from chronically infected mice. Strong reactive recombinants were detected with both sera. Two recombinant clones were studied in more detail and shown to be composed of the same 114-bp repet...
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1991
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 12315caa a22013217a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19359 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205043.0 | ||
| 008 | 190411s1991 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0026248346 | |
| 024 | 7 | |2 Molecular Sequence Numbers |a GENBANK: M64352, S68286, X58796, X58797, X58798, X58799, X58800, X58801, X58802, X58803; | |
| 024 | 7 | |2 cas |a Antibodies, Protozoan; Antigens, Protozoan; Autoantibodies; microtubule-associated protein 1B; Microtubule-Associated Proteins; Recombinant Fusion Proteins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EXPAA | ||
| 100 | 1 | |a Kerner, N. | |
| 245 | 1 | 0 | |a Trypanosoma cruzi: Antibodies to a MAP-like protein in chronic chagas' disease cross-react with mammalian cytoskeleton |
| 260 | |c 1991 | ||
| 270 | 1 | 0 | |m Hontebeyrie-Joskowicz, M.; Institut Pasteur, 28, Rue du Docteur Roux, 75724 Paris Cedex15, France |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Noble, Lewis, Cowan, The microtubule binding domain of microtubule-associated protein MAP1b contains a repeated sequence motif unrelated to that of MAP2 and Tau (1989) Journal of Cellular Biology, 109, pp. 3367-3376 | ||
| 504 | |a Nunez, Immature and mature variants of MAP2 and Tau proteins and neuronal plasticity (1988) Trends in Neurological Sciences, 11, pp. 477-479 | ||
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| 504 | |a Petry, Eisen, Chagas disease: A model for the study of autoimmune diseases (1989) Parasitology Today, 5, pp. 111-116 | ||
| 504 | |a Petry, Van Voorhis, Antigens of Trypanosoma cruzi that mimic mammalian nervous tissues: investigations of their role in the autoimmune pathophysiology of chronic Chagas' disease (1991) Research in Immunology, 142, pp. 151-156 | ||
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| 504 | |a Seebeck, Hemphill, Lawson, The cytoskeleton of trypanosomes (1990) Parasitology Today, 6, pp. 49-52 | ||
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| 504 | |a Ullmann, One-step purification of hybrid proteins which have β-galactosidase activity (1984) Gene, 29, pp. 27-31 | ||
| 504 | |a Van der Ploeg, Smits, Ponnudurai, Vermeulen, Meuwissen, Langsley, Chromosome-sized DNA molecules of Plasmodium falciparum (1985) Science, 229, pp. 658-661 | ||
| 504 | |a Van Voorhis, Eisen, A surface antigen of Trypanosoma cruzi that mimics mammalian nervous tissue (1989) Journal of Experimental Medicine, 169, pp. 641-652 | ||
| 520 | 3 | |a Trypanosoma cruzi λgtll library from epimastogote derived mRNA was screened with human chagasic sera or sera from chronically infected mice. Strong reactive recombinants were detected with both sera. Two recombinant clones were studied in more detail and shown to be composed of the same 114-bp repetitive sequence coding for a 38 amino acid repetition. This repetition is the same size and shares >60% homology with the reported T. brucei microtubule associated protein (MAP) p320. The insert of one of these clones, K1-7 (228 bp), was subcloned into pMSgt11 and the soluble recombinant polypeptide expressed. Antibodies against the K1-7 fusion polypeptide recognized a major 110-kDa band from Cytoskeleton. Anti K1-7 monospecific antibodies detected several cytoskeletal proteins from 3T3 fibroblasts and bovine brain microtubule preparations. Reciprocally, anti-MAP1b monoclonal antibodies raised against bovine brain microtubule reacted with the K1-7 polypeptide on Western blots. The protein identified by K1-7 antibodies may be one of the parasite molecules associated to molecular mimicry. © 1991. |l eng | |
| 536 | |a Detalles de la financiación: We thank Dr Jesus Avila for generous gift of anti-mammalian MAPS antibodies and Dr Gordon Langsley for pulse field gel electrophoresis. We are very grateful to Serge Bonnefoy for his enthusiastic collaboration, and Arthur Scherf and Denise Mattei for helpful discussions and constant interest and encouragement. The continuous interest and critical comments of Charles Roth are gratefully acknowledged. We also thank Josyane Lozner for typing this manuscript. This work was supported by the French-Argentinian Co-operation Program (INSERM-CONICET) and Pasteur Institute (France). | ||
| 593 | |a Institut Pasteur, 28, Rue du Docteur Roux, 75724 Paris Cedex15, France | ||
| 593 | |a Instituto de Ingeniaria Génética y Biologia Molecular, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CDNA LIBRARY |
| 690 | 1 | 0 | |a CHAGAS' DISEASE |
| 690 | 1 | 0 | |a CYTOSKELETON |
| 690 | 1 | 0 | |a IMMUNOSCREENING |
| 690 | 1 | 0 | |a MOLECULAR MIMICRY |
| 690 | 1 | 0 | |a PROTOZOA |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI MAP-LIKE ANTIGEN |
| 690 | 1 | 0 | |a AUTOANTIBODY |
| 690 | 1 | 0 | |a HYBRID PROTEIN |
| 690 | 1 | 0 | |a MICROTUBULE ASSOCIATED PROTEIN |
| 690 | 1 | 0 | |a MICROTUBULE ASSOCIATED PROTEIN 5 |
| 690 | 1 | 0 | |a MICROTUBULE ASSOCIATED PROTEINS |
| 690 | 1 | 0 | |a MICROTUBULE-ASSOCIATED PROTEIN 1B |
| 690 | 1 | 0 | |a PARASITE ANTIGEN |
| 690 | 1 | 0 | |a PROTOZOON ANTIBODY |
| 690 | 1 | 0 | |a AMINO ACID SEQUENCE |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a CHRONIC DISEASE |
| 690 | 1 | 0 | |a CROSS REACTION |
| 690 | 1 | 0 | |a CYTOSKELETON |
| 690 | 1 | 0 | |a IMMUNOLOGY |
| 690 | 1 | 0 | |a MOLECULAR GENETICS |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NUCLEOTIDE REPEAT |
| 690 | 1 | 0 | |a NUCLEOTIDE SEQUENCE |
| 690 | 1 | 0 | |a AMINO ACID SEQUENCE |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ANTIBODIES, PROTOZOAN |
| 690 | 1 | 0 | |a ANTIGENS, PROTOZOAN |
| 690 | 1 | 0 | |a AUTOANTIBODIES |
| 690 | 1 | 0 | |a BASE SEQUENCE |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a CHRONIC DISEASE |
| 690 | 1 | 0 | |a CROSS REACTIONS |
| 690 | 1 | 0 | |a CYTOSKELETON |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICROTUBULE-ASSOCIATED PROTEINS |
| 690 | 1 | 0 | |a MOLECULAR SEQUENCE DATA |
| 690 | 1 | 0 | |a RECOMBINANT FUSION PROTEINS |
| 690 | 1 | 0 | |a REPETITIVE SEQUENCES, NUCLEIC ACID |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 700 | 1 | |a Liégeard, P. | |
| 700 | 1 | |a Levin, M.J. | |
| 700 | 1 | |a Hontebeyrie-Joskowicz, M. | |
| 773 | 0 | |d 1991 |g v. 73 |h pp. 451-459 |k n. 4 |p Exp. Parasitol. |x 00144894 |w (AR-BaUEN)CENRE-4717 |t Experimental Parasitology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0014-4894(91)90069-9 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00144894_v73_n4_p451_Kerner |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144894_v73_n4_p451_Kerner |y Registro en la Biblioteca Digital |
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