Aerobic fermentation of glucose by trypanosomatids
The consumption of glucose by trypanosomatid protozoa such as Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., and Crithidia spp. is characterized by the excretion of reduced products such as succinate, pyruvate, ethanol, L-alanine, or lactate (depending on the species) not only in anaerobios...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1992
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| Materias: | |
| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 03868caa a22007337a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19292 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230607131911.0 | ||
| 008 | 190411s1992 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0026699609 | |
| 024 | 7 | |2 cas |a amino acid, 65072-01-7; glucose, 50-99-7, 84778-64-3; malic acid, 149-61-1, 6915-15-7; reduced nicotinamide adenine dinucleotide, 58-68-4; Amino Acids; Carbohydrates; Glucose, 50-99-7; NAD, 53-84-9 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a FAJOE | ||
| 100 | 1 | |a Cazzulo, J.-J. | |
| 245 | 1 | 0 | |a Aerobic fermentation of glucose by trypanosomatids |
| 260 | |c 1992 | ||
| 270 | 1 | 0 | |m Cazzulo, J.-J.; Fac. de Ciencias Exactas/Naturales, Inst. de Investigaciones Bioquimicas, Universidad de Buenos Aires, 1405 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a The consumption of glucose by trypanosomatid protozoa such as Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., and Crithidia spp. is characterized by the excretion of reduced products such as succinate, pyruvate, ethanol, L-alanine, or lactate (depending on the species) not only in anaerobiosis, but also under aerobic conditions. The 'aerobic fermentation' of glucose is accompanied by a complete lack, or even a reversal, of the Pasteur effect. This peculiar catabolism is mediated by a so-far unique compartmentation of the glycolytic enzymes, most of which are placed in an organelle called the glycosome; by an almost complete lack of inhibitory controls at the level of hexokinase and phosphofructokinase; and by a central role of CO2 fixation through the reaction catalyzed by phosphoenolpyruvate carboxykinase. The production of fermentative products seems to be due to a relative inefficiency of the respiratory chain, which lacks NADH dehydrogenase and the first phosphorylation site and preferentially uses succinate as substrate. |l eng | |
| 593 | |a Fac. de Ciencias Exactas/Naturales, Inst. de Investigaciones Bioquimicas, Universidad de Buenos Aires, 1405 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANAEROBIC |
| 690 | 1 | 0 | |a CARBOHYDRATE |
| 690 | 1 | 0 | |a GLUCOSE CATABOLISM |
| 690 | 1 | 0 | |a GLYCOLYTIC ENZYMES |
| 690 | 1 | 0 | |a LEISHMANIAS |
| 690 | 1 | 0 | |a PASTEUR EFFECT |
| 690 | 1 | 0 | |a AMINO ACID |
| 690 | 1 | 0 | |a GLUCOSE |
| 690 | 1 | 0 | |a MALIC ACID |
| 690 | 1 | 0 | |a REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a FERMENTATION |
| 690 | 1 | 0 | |a GLUCOSE UTILIZATION |
| 690 | 1 | 0 | |a GLYCOLYSIS |
| 690 | 1 | 0 | |a LEISHMANIA |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OXIDATION |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN DEGRADATION |
| 690 | 1 | 0 | |a REVIEW |
| 690 | 1 | 0 | |a TRYPANOSOMA BRUCEI |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a AMINO ACIDS |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CARBOHYDRATES |
| 690 | 1 | 0 | |a FERMENTATION |
| 690 | 1 | 0 | |a GLUCOSE |
| 690 | 1 | 0 | |a NAD |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TRYPANOSOMATINA |
| 690 | 1 | 0 | |a CRITHIDIA |
| 690 | 1 | 0 | |a PROTOZOA |
| 690 | 1 | 0 | |a TRYPANOSOMA |
| 690 | 1 | 0 | |a TRYPANOSOMA BRUCEI |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 690 | 1 | 0 | |a TRYPANOSOMATIDAE |
| 650 | 1 | 7 | |2 spines |a AEROBIOSIS |
| 773 | 0 | |d 1992 |g v. 6 |h pp. 3153-3161 |k n. 13 |p FASEB J. |x 08926638 |w (AR-BaUEN)CENRE-996 |t FASEB Journal | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026699609&partnerID=40&md5=340c250066334e32656d9888daee22ad |y Registro en Scopus |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_08926638_v6_n13_p3153_Cazzulo |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v6_n13_p3153_Cazzulo |y Registro en la Biblioteca Digital |
| 961 | |a paper_08926638_v6_n13_p3153_Cazzulo |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 80245 | ||