Growth inhibition in vitro of murine mammary adenocarcinoma cells by heparin and chemically modified heparins
Heparin, a highly sulfated polysaccharide used as an antithrombotic and anticoagulant, inhibits proliferation of several cell types. We have investigated the effect of heparin and chemically modified heparins on the growth of a cell culture of a murine mammary adenocarcinoma (M3). We found that hepa...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1994
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 10201caa a22011057a 4500 | ||
|---|---|---|---|
| 001 | PAPER-19145 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205030.0 | ||
| 008 | 190411s1994 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0028033260 | |
| 024 | 7 | |2 cas |a heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5; Heparin, 9005-49-6 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Bertolesi, G.E. | |
| 245 | 1 | 0 | |a Growth inhibition in vitro of murine mammary adenocarcinoma cells by heparin and chemically modified heparins |
| 260 | |c 1994 | ||
| 270 | 1 | 0 | |m Bertolesi, G.E.; Area de Investigaciones, Instituto de Oncología ‘A.H. Roffo’, Universidad de Buenos Aires, Av. San Martin 5481, Buenos Aires, 1417, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Casu, B., Structure and biological activity of heparin (1985) Adv Carbohydr Chem Biochem, 43, pp. 51-134 | ||
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| 504 | |a Wright, T.C., Johnstone, T.V., Castellot, J.J., Inhibition of rat cervical epithelial cell growth by heparin and its reversal by EGF (1985) J Cell Physiol, 125, pp. 499-506 | ||
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| 504 | |a Oyama, V., Eagle, H., Measurement of cell growth in tissue culture with phenol reagent (Folin-Ciocaltcau) (1956) Proc Soc Exp Biol Med, 91, pp. 305-307 | ||
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| 504 | |a Castellot, J.J., Beeler, D.L., Rosenberg, R.D., Structural determinants of the capacity of heparin to inhibit the proliferation of vascular smooth muscle cells (1984) J Cell Physiol, 120, pp. 315-320 | ||
| 504 | |a Castellot, J.J., Wong, K., Herman, B., Binding and internalization of heparin by vascular smooth muscle cells (1985) J Cell Physyol, 124, pp. 13-20 | ||
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| 504 | |a Ishaì-Michaeli, R., Svahn, C.-M., Webwe, M., Importance of size and sulfation of heparin in release of basic fibroblast growth factor from the vascular endothelium and extracellular matrix (1992) Biochemistry, 31, pp. 2080-2088 | ||
| 504 | |a Bar-Ner, M., Eldor, A., Wasserman, Y., Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anti-coagulant heparin species (1987) Blood, 70, pp. 551-557 | ||
| 504 | |a Coombe, D.R., Pariesh, C.R., Ramshaw, I.A., Analysis of the inhibition of tumour metastasis by sulfated polysaccharides (1987) Int J Cancer, 39, pp. 82-88 | ||
| 504 | |a Nakajima, M., Irimura, T., Nicolson, G.L., Heparanases and tumor metastases (1988) J Cell Biochem, 36, pp. 157-1678 | ||
| 504 | |a Parish, C.R., Coombe, D.R., Jakobsen, K.B., Evidence that sulphated polysaccharides inhibit tumour metastasis by blocking tumour-cell-derived heparanases (1987) Int J Cancer, 40, pp. 511-517 | ||
| 520 | 3 | |a Heparin, a highly sulfated polysaccharide used as an antithrombotic and anticoagulant, inhibits proliferation of several cell types. We have investigated the effect of heparin and chemically modified heparins on the growth of a cell culture of a murine mammary adenocarcinoma (M3). We found that heparin inhibited the proliferation of M3 cells growing either with or without 2% fetal calf serum (FCS) in a dose-dependent and reversible fashion. Several heparins with different anticoagulant properties showed a similar antiproliferative effect. Histological assays showed that heparin was internalized and appeared in cytoplasmic vesicules. O-desulfated. O/N-desul- fated N-acetylated and N-desulfated heparins lost their antiproliferative activity, while N-desulfated N-acetylated heparin significantly inhibited cell proliferation with or without FCS. The finding of an antiproliferative action of N-desulfated N-acetylated heparin which does not show anticoagulant activity suggests a possible therapeutic role for this compound as an antineoplastic drug. © 1994 S. Karger AG, Basel. |l eng | |
| 593 | |a Area de Investigaciones, Institute de Oncología ‘A.H. Roffo’, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Laboratorio de Histología Animal, Departamento de Biología, Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a GROWTH |
| 690 | 1 | 0 | |a HEPARIN |
| 690 | 1 | 0 | |a HEPARINOID |
| 690 | 1 | 0 | |a INHIBITION |
| 690 | 1 | 0 | |a METASTASIS |
| 690 | 1 | 0 | |a MURINE ADENOCARCINOMA |
| 690 | 1 | 0 | |a HEPARIN |
| 690 | 1 | 0 | |a HEPARIN DERIVATIVE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BREAST CARCINOMA |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a GROWTH INHIBITION |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a ADENOCARCINOMA |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CELL DIVISION |
| 690 | 1 | 0 | |a COMPARATIVE STUDY |
| 690 | 1 | 0 | |a CYTOPLASMIC GRANULES |
| 690 | 1 | 0 | |a HEPARIN |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a MAMMARY NEOPLASMS, EXPERIMENTAL |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TIME FACTORS |
| 690 | 1 | 0 | |a TUMOR CELLS, CULTURED |
| 700 | 1 | |a De Cidre, L.L. | |
| 700 | 1 | |a Eiján, A.M. | |
| 773 | 0 | |d 1994 |g v. 15 |h pp. 275-283 |k n. 5 |p Tumor Biol. |x 10104283 |t Tumor Biology | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028033260&doi=10.1159%2f000217902&partnerID=40&md5=fb6def87eeb9e3073dcd0b12bd5b35d5 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1159/000217902 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_10104283_v15_n5_p275_Bertolesi |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10104283_v15_n5_p275_Bertolesi |y Registro en la Biblioteca Digital |
| 961 | |a paper_10104283_v15_n5_p275_Bertolesi |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 80098 | ||