The role of phospholipids in the activity of a4-3-KET0steroid 5αoxidoreductase of the rat ventral prostate
The involvement of phospholipids in the activity of 5αreductase from nuclear and microsomal fractions of rat prostate was studied using phospholipases A and C. Phospholipase A reduced the activity of 5αreductase in both subcellular fractions; this effect was not attributable to the hydrolysis produc...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Informa Healthcare
1977
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 05960caa a22009497a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18650 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205001.0 | ||
| 008 | 190411s1977 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0017684507 | |
| 024 | 7 | |2 cas |a phospholipase C, 9001-86-9; phospholipase, 9013-93-8; steroid reductase, 42616-29-5, 9082-73-9; Oxidoreductases, EC 1.; Phospholipases, EC 3.1.-; Phospholipids; Serum Albumin, Bovine; Testosterone 5-alpha-Reductase, EC 1.3.99.5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ENRSE | ||
| 100 | 1 | |a Charreau, E.H. | |
| 245 | 1 | 4 | |a The role of phospholipids in the activity of a4-3-KET0steroid 5αoxidoreductase of the rat ventral prostate |
| 260 | |b Informa Healthcare |c 1977 | ||
| 270 | 1 | 0 | |m Charreau, E.H.; Laboratorio de Esteroides, Institutio de Biologia y Medicina Experimental, Obligado 2490, Buenos Aires, 1428, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Wilson, J.D., Gloyna, R.E., (1970) Rectn. Progr. Hormone Res., 26, p. 309 | ||
| 504 | |a Frederiksen, D.W., Wilson, J.D., (1971) J. Biol. Chem, 246, p. 2584 | ||
| 504 | |a Shirmazaki, J., Horaguchi, T., Ohki, J., Shida, K., (1971) Endocrinol. Jap., 18, p. 179 | ||
| 504 | |a Moore, R.J., Wilson, J.D., (1972) J. Biol. Chem., 247, p. 958 | ||
| 504 | |a Norzer, D., Tamaoki, B.I., (1974) Biochim. Biophys. Acta, 348, p. 321 | ||
| 504 | |a Emmelot, P., Bos, C.J., (1968) Biochim. Biophys. Acta., 150, p. 341 | ||
| 504 | |a Rethy, A., Tomasi, V., Trevisani, A., (1971) Arch. Biochem, Biophys., 147, p. 36 | ||
| 504 | |a Beaufay, H., de Duve, C., (1954) Bull. Soc. Chim. Biol., 36, p. 1551 | ||
| 504 | |a Duttera, S.M., Byrne, W.L., Ganoza, M.C., (1968) J. Biol. Chem., 243, p. 2216 | ||
| 504 | |a Graham, A.B., Wood, G.L., (1969) Biochem. Biophys. Res. Commun., 37, p. 567 | ||
| 504 | |a Zakim, D., (1970) J. Biol. Chem., 245, p. 4953 | ||
| 504 | |a Charreau, E.H., Villee, C.A., (1968) J. Clin. Endocr. and Metab., 28, p. 1741 | ||
| 504 | |a Saito, K., Hanahan, D.J., (1962) Biochemistry, 1, p. 521 | ||
| 504 | |a Folch, J., Lees, M., Sloane Stanley, G.H., (1957) J. Biol. Chem., 226, p. 497 | ||
| 504 | |a Borgstrom, B., (1952) Acta Physiol. Scand., 25, p. 101 | ||
| 504 | |a Bartlett, G.R., (1959) J. Biol. Chem., 234, p. 466 | ||
| 504 | |a Dole, V.P., (1956) J. Clin. Invest., 35, p. 150 | ||
| 504 | |a Lowry, O.H., Rosbrough, J.J., Farr, A.L., Randall, R.J., (1951) J. Biol. Chem., 193, p. 265 | ||
| 504 | |a Felischer, S., Casu, A., Fleishcher, B., (1964) Fed. Proc., 23, p. 486 | ||
| 504 | |a Casu, A., Fleischer, B., Fleischer, S., (1966) Fed. Proc., 25, pp. 3-4 | ||
| 504 | |a Maronosi, A., (1964) Fed. Proc., 23, p. 913 | ||
| 504 | |a Igo, R.P., Mackler, B., Ducan, J., Ridyard, J.N.A., Hanahan, P.J., (1960) Biochem. Biophys. Acta., 42, p. 55 | ||
| 504 | |a Martonosi, A., (1963) Biochem. Biophys. Res. Commun., 13, p. 273 | ||
| 504 | |a Fiscus, W.G., Schneider, W.C., (1966) J. Biol. Chem., 241, p. 3324 | ||
| 504 | |a Goodman, D.S., (1958) J. Amer. Chem. Soc., 80, p. 3892 | ||
| 504 | |a Verhoeven, D.S., Lamberigts, G., De Moor, P., (1974) J. Steroid Biochem., 5, p. 93 | ||
| 504 | |a Salmoral, E.M., Charreau, E.H., (1974) VIII Pan American. Endocrinol. Meet. Abstr., 56 | ||
| 520 | 3 | |a The involvement of phospholipids in the activity of 5αreductase from nuclear and microsomal fractions of rat prostate was studied using phospholipases A and C. Phospholipase A reduced the activity of 5αreductase in both subcellular fractions; this effect was not attributable to the hydrolysis products. Phospholipase C stopped only the activity of the nuclear fraction. There was no quantitative correlation between hydrolysis of phospholipids and loss of enzyme activity. The inactivation observed seems to result from phospholipase-induced instability of the enzyme. The results suggest that the altered structure of phospholipids and/or the membranes where 5αreductase is located is responsible for the decrease in activity. © 1977 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |l eng | |
| 536 | |a Detalles de la financiación: This work was supported by grants from the Argentine Research Council | ||
| 593 | |a Laboratorio de Esteroides, Institutio de Biologia y Medicina Experimental, Obligado 2490, Buenos Aires, 1428, Argentina | ||
| 690 | 1 | 0 | |a PHOSPHOLIPASE |
| 690 | 1 | 0 | |a PHOSPHOLIPASE A |
| 690 | 1 | 0 | |a PHOSPHOLIPASE C |
| 690 | 1 | 0 | |a PHOSPHOLIPID |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a STEROID REDUCTASE |
| 690 | 1 | 0 | |a 5ALPHA ANDROSTANE 3ALPHA,17BETA DIOL C 14 |
| 690 | 1 | 0 | |a ANDROSTANOLONE C 14 |
| 690 | 1 | 0 | |a MEMBRANE STRUCTURE |
| 690 | 1 | 0 | |a MICROSOME |
| 690 | 1 | 0 | |a PROSTATE |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a TESTOSTERONE H 3 |
| 690 | 1 | 0 | |a THEORETICAL STUDY |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CELL NUCLEUS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICROSOMES |
| 690 | 1 | 0 | |a OXIDOREDUCTASES |
| 690 | 1 | 0 | |a PHOSPHOLIPASES |
| 690 | 1 | 0 | |a PHOSPHOLIPIDS |
| 690 | 1 | 0 | |a PROSTATE |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a SERUM ALBUMIN, BOVINE |
| 690 | 1 | 0 | |a TESTOSTERONE 5-ALPHA-REDUCTASE |
| 700 | 1 | |a Salmoral, E.M. | |
| 773 | 0 | |d Informa Healthcare, 1977 |g v. 4 |h pp. 85-94 |k n. 2 |p Endocr. Res. |x 07435800 |w (AR-BaUEN)CENRE-4569 |t Endocrine Research | |
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| 856 | 4 | 0 | |u https://doi.org/10.3109/07435807709073915 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_07435800_v4_n2_p85_Charreau |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07435800_v4_n2_p85_Charreau |y Registro en la Biblioteca Digital |
| 961 | |a paper_07435800_v4_n2_p85_Charreau |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 79603 | ||