Binding of estradiol receptor complexes to isolated human breast chromatin
The interaction of estradiol-receptor complexes and isolated human breast tumor chromatin was studied under equilibrium conditions. The estradiol-receptor complexes bound specifically to the chromatin of hormone dependent tumors and showed a single class of binding sites with a Ka of 0.96 × 1010m-1...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Kluwer Academic Publishers
1977
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 06787caa a22010457a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18634 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205000.0 | ||
| 008 | 190411s1977 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0017649332 | |
| 024 | 7 | |2 cas |a DNA, 9007-49-2; Chromatin; DNA, Neoplasm; Estradiol, 50-28-2; Receptors, Estrogen; Sodium Chloride, 7647-14-5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MCBIB | ||
| 100 | 1 | |a Charreau, E.H. | |
| 245 | 1 | 0 | |a Binding of estradiol receptor complexes to isolated human breast chromatin |
| 260 | |b Kluwer Academic Publishers |c 1977 | ||
| 270 | 1 | 0 | |m Charreau, E.H.; Instituto de Biologia y Medicina Experimental, Obligado 2490, Buenos Aires, 1428, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Jensen, E.V., De Sombre, E.R., (1972) A. Rev. Biochem., 41, pp. 203-230 | ||
| 504 | |a Jensen, E.V., Suzuki, T., Kawashima, T., Stumpf, W.E., Jungblut, P.W., De Sombre, E.R., (1968) Proc. Nat. Acad. Sci. USA, 59, pp. 632-638 | ||
| 504 | |a Giannopoulos, G., Gorski, J., (1971) J. Biol. Chem., 246, pp. 2530-2536 | ||
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| 504 | |a “Estrogen Receptors in Human Breast Cancer”, McGuire W. L., Carbone P. P. and Vollmer E. P. editors. Raven Press New York 1975; Toft, D., Gorski, J., (1966) Proc. Nat. Acad. Sci. USA, 55, pp. 1574-1581 | ||
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| 504 | |a Britten, R., Graham, D.E., Neufed, B.R., (1974) Methods in Enzymology, pp. 363-418. , L., Grossman, K., Moldave, Acad. Press, N.Y | ||
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| 504 | |a McGuire, W.L., Huff, K., Chamness, G.C., (1972) Biochemistry, 11, pp. 4562-4565 | ||
| 504 | |a Jensen, E.W., Hurst, D.J., De Sombre, E.R., Jungblut, P.W., (1967) Science, 158, pp. 385-387 | ||
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| 504 | |a Chamness, G.C., Jennings, A.W., McGuire, W.L., (1974) Biochemistry, 13, pp. 327-331 | ||
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| 504 | |a Baldi, A., Charreau, E.H., (1975) Medicina, 35, p. 594 | ||
| 520 | 3 | |a The interaction of estradiol-receptor complexes and isolated human breast tumor chromatin was studied under equilibrium conditions. The estradiol-receptor complexes bound specifically to the chromatin of hormone dependent tumors and showed a single class of binding sites with a Ka of 0.96 × 1010m-1 and a binding capacity of 1.5 pmoles/mg DNA. The binding was a temperature-dependent process and involved a "transformation" of the receptor protein. The heat-activated hormone-receptor com-plex was more active than the 8S form in the binding phenomenon. The specific interaction of estradiol-receptor complex with isolated chromatin was saturable and sensitive to conditions of temperature and ionic strength. Furthermore under optimal conditions no acceptor sites were detected in chromatin of hormone independent tumors. © 1977 Dr. W. Junk b.v. Publishers. |l eng | |
| 593 | |a Instituto de Biologia y Medicina Experimental, Obligado 2490, Buenos Aires, 1428, Argentina | ||
| 690 | 1 | 0 | |a ALBUMIN I 125 |
| 690 | 1 | 0 | |a DNA |
| 690 | 1 | 0 | |a DRUG RECEPTOR |
| 690 | 1 | 0 | |a ESTRADIOL RECEPTOR |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a BREAST |
| 690 | 1 | 0 | |a BREAST CARCINOMA |
| 690 | 1 | 0 | |a CHROMATIN |
| 690 | 1 | 0 | |a ESTRADIOL H 3 |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a NORMAL HUMAN |
| 690 | 1 | 0 | |a RNA C 14 |
| 690 | 1 | 0 | |a THEORETICAL STUDY |
| 690 | 1 | 0 | |a BREAST NEOPLASMS |
| 690 | 1 | 0 | |a CHROMATIN |
| 690 | 1 | 0 | |a DNA, NEOPLASM |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a OSMOLAR CONCENTRATION |
| 690 | 1 | 0 | |a RECEPTORS, ESTROGEN |
| 690 | 1 | 0 | |a SODIUM CHLORIDE |
| 690 | 1 | 0 | |a TEMPERATURE |
| 700 | 1 | |a Baldi, A. | |
| 773 | 0 | |d Kluwer Academic Publishers, 1977 |g v. 16 |h pp. 79-86 |k n. 2-3 |p Mol Cell Biochem |x 03008177 |w (AR-BaUEN)CENRE-3498 |t Molecular and Cellular Biochemistry | |
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| 856 | 4 | 0 | |u https://doi.org/10.1007/BF01732047 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03008177_v16_n2-3_p79_Charreau |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03008177_v16_n2-3_p79_Charreau |y Registro en la Biblioteca Digital |
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