Adrenoceptors involved in the contractile activity of isolated pregnant rat uterus
Cumulative log dose-response curves of soterenol, isoproterenol, phenylephrine and norepinephrine on isolated pregnant rat uterus at different days of gestation, were investigated. Soterenol produced a sustained inhibition of spontaneous motility during the whole pregnancy and this effect was blocke...
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| Otros Autores: | , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1979
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| Materias: | |
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 05135caa a22007097a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18602 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204959.0 | ||
| 008 | 190411s1979 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84886618123 | |
| 024 | 7 | |2 cas |a butoxamine, 1937-89-9; isoprenaline, 299-95-6, 51-30-9, 6700-39-6, 7683-59-2; noradrenalin, 1407-84-7, 51-41-2; phentolamine, 50-60-2, 73-05-2; phentolamine mesylate, 65-28-1; phenylephrine, 532-38-7, 59-42-7, 61-76-7; practolol, 6673-35-4; progesterone, 57-83-0; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; soterenol, 13642-52-9, 14816-67-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EJPHA | ||
| 100 | 1 | |a Borda, E. | |
| 245 | 1 | 0 | |a Adrenoceptors involved in the contractile activity of isolated pregnant rat uterus |
| 260 | |c 1979 | ||
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a Cumulative log dose-response curves of soterenol, isoproterenol, phenylephrine and norepinephrine on isolated pregnant rat uterus at different days of gestation, were investigated. Soterenol produced a sustained inhibition of spontaneous motility during the whole pregnancy and this effect was blocked by butoxamine. The affinity of myometrium for the β2-adrenoceptor agonist was parallel to the concentration of progesterone in plasma during pregnancy. Isoproterenol, norepinephrine and phenylephrine caused dual, α- and β-mediated responses; their relative dominance varied with the concentration and the days of pregnancy. α-Adrenoceptor effects of the amines coincided with increased plasma concentrations of estrogens, whereas β ones were in parallel with the increment of plasma progesterone. It is concluded that: there exist in the pregnant rat uterus β2-receptor-mediated responses influenced by the length of gestation; and the concentration-pregnancy-dependent biphasic actions of isoproterenol, norepinephrine or phenylephrine suggest that their variable hormone-modulated ability interacts with both α- and β-adrenoceptive uterine sites. |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: University of Washington | ||
| 536 | |a Detalles de la financiación: * This work has been supported by Grant 6638 from the Concejo Nacional de Investigaciones Cientfficas y T~cnicas de la Repfiblica Argentina and by the Washington University, School of Medicine Out-patient Clinic, St. Louis Missouri, U.S.A. ** Junior Investigator of the Consejo Nacional de Investigaciones Cientfficas y T~cnicas de la Repfiblica Argentina. *** Associate Professor of Obstetrics and Gynecology, Washington University School of Medicine, Barnes Hospital Plaza, St. Louis Missouri, U.S.A. **** Senior Investigator of the Consejo Nacional de Investigaciones Cientfficas y T~cnicas de la Repfiblica Argentina. Send correspondence to: Alvaro L. Gime-no, M.D., Cefaprin, Obligado 2490, 1428 Buenos Aires, Argentina. | ||
| 593 | |a Centro de Estudios Farmacológicos y de Principios Naturales CEFAPRIN, Consejo Nacional de Investigaciones Cientificas, Técnicas de la República Argentina CONICET, Buenos Aires, Argentina | ||
| 593 | |a Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, United States | ||
| 690 | 1 | 0 | |a ALPHA ADRENERGIC RECEPTOR |
| 690 | 1 | 0 | |a BETA ADRENERGIC RECEPTOR |
| 690 | 1 | 0 | |a BUTOXAMINE |
| 690 | 1 | 0 | |a ISOPRENALINE |
| 690 | 1 | 0 | |a NORADRENALIN |
| 690 | 1 | 0 | |a PHENTOLAMINE |
| 690 | 1 | 0 | |a PHENTOLAMINE MESYLATE |
| 690 | 1 | 0 | |a PHENYLEPHRINE |
| 690 | 1 | 0 | |a PRACTOLOL |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a PROPRANOLOL |
| 690 | 1 | 0 | |a SOTERENOL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a BLOOD AND HEMOPOIETIC SYSTEM |
| 690 | 1 | 0 | |a DOSE RESPONSE |
| 690 | 1 | 0 | |a DRUG COMPARISON |
| 690 | 1 | 0 | |a DRUG INTERACTION |
| 690 | 1 | 0 | |a DRUG RESPONSE |
| 690 | 1 | 0 | |a ESTROGEN BLOOD LEVEL |
| 690 | 1 | 0 | |a FEMALE GENITAL SYSTEM |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PROGESTERONE BLOOD LEVEL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a UTERUS CONTRACTILITY |
| 690 | 1 | 0 | |a UTERUS CONTRACTION |
| 653 | 0 | 0 | |a regitine |
| 700 | 1 | |a Sauvage, J. | |
| 700 | 1 | |a Sterin-Borda, L. | |
| 700 | 1 | |a Gimeno, M.F. | |
| 700 | 1 | |a Gimeno, A.L. | |
| 773 | 0 | |d 1979 |g v. 56 |h pp. 61-67 |k n. 1-2 |p EUR. J. PHARMACOL. |x 00142999 |w (AR-BaUEN)CENRE-1772 |t European Journal of Pharmacology | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886618123&doi=10.1016%2f0014-2999%2879%2990433-3&partnerID=40&md5=03f8c10dc51a09ea5c945dcec2352052 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0014-2999(79)90433-3 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00142999_v56_n1-2_p61_Borda |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v56_n1-2_p61_Borda |y Registro en la Biblioteca Digital |
| 961 | |a paper_00142999_v56_n1-2_p61_Borda |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 79555 | ||