Augmented thromboxane generation by mesenteric arteries from pancreatectomized diabetic dogs is coincident with the vascular tone enhancement evoked by Na arachidonate and prostacyclin
We studied the relationships between acrachidonic acid (AA) metabolism and contractile responses to Na arachidonate (NaA) and the prostaglandins (PGs) in mesenteric arteries isolated from sham-operated and totally pancreatectomized dogs. PGE2 and PGF2α produced a similar dose-dependent relaxation of...
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| Formato: | Capítulo de libro |
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1984
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 15485caa a22016097a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18277 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204939.0 | ||
| 008 | 190411s1984 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0021162854 | |
| 024 | 7 | |2 cas |a 5,8,11,14 icosatetraynoic acid, 1191-85-1; acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; haloperidol, 52-86-8; imidazole, 1467-16-9, 288-32-4; indometacin, 53-86-1, 74252-25-8, 7681-54-1; insulin, 9004-10-8; nordihydroguaiaretic acid, 500-38-9; phentolamine, 50-60-2, 73-05-2; phentolamine mesylate, 65-28-1; prostacyclin, 35121-78-9, 61849-14-7; prostaglandin synthase, 39391-18-9, 59763-19-8, 9055-65-6; thromboxane, 66719-58-2; tranylcypromine, 13492-01-8, 155-09-9, 54-97-7; Arachidonic Acid, 506-32-1; Arachidonic Acids; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Epoprostenol, 35121-78-9; Prostaglandins; Prostaglandins E; Prostaglandins F; Thromboxanes | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EJPHA | ||
| 100 | 1 | |a Sterin-Borda, L. | |
| 245 | 1 | 0 | |a Augmented thromboxane generation by mesenteric arteries from pancreatectomized diabetic dogs is coincident with the vascular tone enhancement evoked by Na arachidonate and prostacyclin |
| 260 | |c 1984 | ||
| 270 | 1 | 0 | |m Gimeno, A.L.; Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET), Serrano 665/69, 1414 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Armstrong, Lattimer, Moncada, Vane, Comparison of the vasodepressor effects of prostacyclin and 6-oxo-prostaglandin F1α with those of prostaglandin E2 in rats and rabbits (1978) Br. J. Pharmacol., 62, p. 125 | ||
| 504 | |a Aznavoorian, Utsunomiya, Krausz, Cohn, Shepro, Hechtman, Prostacyclin inhibits 5-hydroxytryptamine release but stimulates thromboxane synthesis during cardiopulmonary bypass (1983) Prostaglandins, 25, p. 557 | ||
| 504 | |a Belo, Talesnik, Coronary vasoconstrictor and vasodilator actions of arachidonic acid in the isolated perfused heart of the rat (1982) Br. J. Pharmacol., 75, p. 768 | ||
| 504 | |a Borda, Del C. Agostini, Sterin-Speziale, Gimeno, Gimeno, Spontaneous contractile activity of isolated ovarian human vein. Influence of PGI2 (1979) Prostaglandins, 18, p. 829 | ||
| 504 | |a Borda, Sterin-Borda, Gimeno, Lazzari, Gimeno, The stimulatory effect of prostacyclin (PGI2) on isolated rabbit and rat aorta is probably associated to the generation of a thromboxane A2 (TXA2)-‘like material’ (1983) Arch. Int. Pharmacodyn., 261, p. 79 | ||
| 504 | |a Carreras, Chamone, Klerck, Vermylen, Decreased vascular PGI2 in diabetic rats. Stimulation of PGI2 release in normal and diabetic rats by the antithrombotic compounds Bay 6575 (1980) Thromb. Res., 19, p. 663 | ||
| 504 | |a Christlieb, Janka, Kraus, Gleason, Icadas-Cabral, Aiello, Cabral, Solano, Vascular reactivity to angiotensin II and to norepinephrine in diabetic subjects (1976) Diabetes, 25, p. 268 | ||
| 504 | |a Colwell, Chambere, Laimin, Increased platelet aggregation in early diabetes (1975) Diabetes, 24, p. 684 | ||
| 504 | |a Dusting, Moncada, Vane, Prostacyclin is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid (1977) Prostaglandins, 13, p. 3 | ||
| 504 | |a Ellis, Oelz, Roberts, Payne, Sweetman, Nies, Dates, Coronary arterial smooth muscle contraction by a substance released from platelets. Evidence that it is TXA2 (1976) Science, 193, p. 1135 | ||
| 504 | |a Feigen, Chapnick, Hyman, King, Maroscalvo, Kadowitz, Peripheral vasodilator effects of prostaglandins. Comparison of 6-keto PGE1 with PGI2 and escape from PGE2 in mesenteric vascular bed (1980) J. Pharmacol. Exp. Ther., 217, p. 528 | ||
| 504 | |a Ganda, Pathogenesis of macrovascular disease in the human diabetes (1980) Diabetes, 29, p. 931 | ||
| 504 | |a Gerrard, Stuart, Rao, Steffes, Mauer, Brown, White, Alteration in the balance of prostaglandin and thromboxane synthesis in diabetic rats (1980) J. Lab. Clin. Med., 95, p. 950 | ||
| 504 | |a Gimeno, Sterin-Borda, Borda, Lazzari, Gimeno, Human plasma transforms PGI2 into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries (1980) Prostaglandins, 9, p. 907 | ||
| 504 | |a Gimeno, Sterin-Borda, Borda, Del Castillo, Gimeno, Arachidonate evokes constriction of coronary and mesenteric arteries isolated from diabetic dogs (1983) Advances in Prostaglandin, Thromboxane and Leukotriene Research, 12, p. 235. , B. Samuelsson, R. Paoletti, P. Ramwell, Raven Press, New York | ||
| 504 | |a Gryglewski, Prostaglandin and thromboxane biosynthesis inhibitors (1977) Naunyn-Schmiedeb. Arch. Pharmacol., 297, p. 585 | ||
| 504 | |a Gryglewski, Bunting, Moncada, Flower, Vane, Arterial walls are protected against deposition of platelet thrombin by a substance (PGX), which they may from prostaglandin endoperoxide (1976) Prostaglandins, 12, p. 685 | ||
| 504 | |a Halushka, Rogers, Loadholt, Colwell, Increased platelet thromboxane synthesis in diabetes mellitus (1981) J. Lab. Clin. Med., 97, p. 87 | ||
| 504 | |a Hamberg, On the formation of thromboxane B2 and 12L-hydroxy-5,8,10,14-eicosatetraenoic (12 OH-20:4) in tissues from guinea pig (1976) Biochim. Biophys. Acta, 431, p. 651 | ||
| 504 | |a Hamberg, Samuelsson, Prostaglandin endoperoxides. Novel transformation of arachidonic acid in human platelets (1974) Proc. Natl. Acad. Sci. U.S.A., 71, p. 3400 | ||
| 504 | |a Hamberg, Svensson, Samuelsson, Thromboxanes a new group of biologically active compounds derived from prostaglandin endoperoxides (1975) Proceedings of the National Academy of Sciences, 72, p. 2991 | ||
| 504 | |a Ingerman-Wojenski, Silver, Smith, Macarale, Bovine endothelial cells in culture produce thromboxane as well as prostacyclin (1981) J. Clin. Invest., 67, p. 1292 | ||
| 504 | |a Karper, Pritchard, Jr., Merola, Panganamala, Alterations of the prostacyclin-thromboxane ratio in streptozotocin induced diabetics rats (1982) Prostaglandins, Leukotrienes and Medicine, 8, p. 93 | ||
| 504 | |a Moncada, Biological importance of prostacyclin (1982) Br. J. Pharmacol., 76, p. 31 | ||
| 504 | |a Moncada, Bunting, Mullane, Thorazood, Vane, Imidazole: a selective inhibitor of thromboxane synthetase (1977) Prostaglandins, 13, p. 611 | ||
| 504 | |a Moncada, Gryglewski, Bunting, Vane, An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation (1976) Nature (London), 263, p. 663 | ||
| 504 | |a Needleman, Kulkerni, Raz, Coronary tone modulation, formation and actions of prostaglandins endoperoxides and thromboxanes (1977) Science, 195, p. 409 | ||
| 504 | |a Nugteren, Jouvenaz, Dutilh, Determinations of prostaglandins and other products of arachidonate oxygenation in perfusates and during platelet aggregation (1978) Acta Biol. Med. Germ., 27, p. 701 | ||
| 504 | |a Owen, Carrier, Alteration in vascular smooth muscle sensitivity to vasoconstrictor agents by streptozotocin-induced diabetes (1979) Proc. West. Pharmacol. Soc., 22, p. 363 | ||
| 504 | |a Rosen, Schrör, Increased prostacyclin release from perfused hearts of acutely diabetic rats (1980) Diabetologia, 18, p. 391 | ||
| 504 | |a Roth, Riebel, Lefer, Vascular responsiveness and eicosanoid production in diabetic rats (1983) Diabetología, 24, p. 372 | ||
| 504 | |a Salzman, Salmon, Moncada, Prostacyclin and thromboxane A2 synthesis by rabbit pulmonary artery (1980) J. Pharmacol. Exp. Ther., 215, p. 240 | ||
| 504 | |a Schrör, Moncada, Obatuba, Vane, Transformation of arachidonic acid and prostaglandin endoperoxides by the guinea pig heart Formation of RCS and prostacyclin (1978) European Journal of Pharmacology, 47, p. 103 | ||
| 504 | |a Sterin-Borda, Borda, Del Castillo, Gimeno, Gimeno, Mechanism of coronary vasoconstriction induced by Na arachidonate in experimental diabetic dogs (1982) Experientia, 38, p. 835 | ||
| 504 | |a Sterin-Borda, Borda, Gimeno, Lazzari, Del Castillo, Gimeno, Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs (1982) Diabetología, 22, p. 56 | ||
| 504 | |a Sterin-Borda, Canga, Borda, Gimeno, Gimeno, Inotropic effect of PGI2 on isolated rat atria at different contraction frequency (1980) Naunyn-Schmiedeb. Arch. Pharmacol., 313, p. 95 | ||
| 504 | |a Tuvemo, Strandberg, Hamberg, Samuelsson, Formation and action of prostaglandin endoperoxides in the isolated human umbilical artery (1976) Acta Physiol. Scand., 96, p. 145 | ||
| 504 | |a Urgoiti, Houssay, Rietti, Hypophyseal and adrenal factors essential for ketoacidosis of pancreatectomized dogs (1963) Diabetes, 12, p. 301 | ||
| 504 | |a Vane, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like dugs (1971) Nature New Biol., 231, p. 232 | ||
| 504 | |a Vane, McGiff, Possible contributions of endogenous prostaglandins to the control of blood pressure (1975) Circ. Res., 36, p. 68 | ||
| 504 | |a Wicks, Rose, Johnson, Ramwell, Kot, Vascular responses to arachidonic acid in the perfused canine lung (1976) Circ. Res., 38, p. 167 | ||
| 504 | |a Wolfe, Rostworowski, Manku, Measurement of prostaglandin synthesis and release from rat aortic tissue and from the perfused mesenteric artery by gas chromatographic mass spectrometric methods (1979) Prostacyclin, p. 113. , J.R. Vaner, S. Bergström, Raven Press, New York | ||
| 504 | |a Wong, Malik, Desiderio, McGiff, Sun, Hepatic metabolism of prostacyclin in the rabbit: formation of a potent novel inhibitor of platelet aggregation (1980) Biophys. Res. Commun., 93, p. 486 | ||
| 520 | 3 | |a We studied the relationships between acrachidonic acid (AA) metabolism and contractile responses to Na arachidonate (NaA) and the prostaglandins (PGs) in mesenteric arteries isolated from sham-operated and totally pancreatectomized dogs. PGE2 and PGF2α produced a similar dose-dependent relaxation of mesenteric arteries from normal and diabetic dogs. On the contrary, NaA and prostacyclin (PGI2) enhanced the resting basal tone of arteries from pancreatectomized animals but depressed it in arteries from intact normal control or from sham-operated groups. Inhibitors of thromboxane A2 (TXA2) biosynthesis abolished in vitro the vasoconstricting effect of NaA and PGI2 in diabetics whereas inhibitors of PGI2 biosynthesis blocked the vasodilating influence of NaA in normal mesenteric vessels. Additionally, antagonists of cycooxygenase activity prevented both the vasoconstricting and the vasodilating actions of NaA in normal and in diabetic arteries, respectively, as well as the PGI2 tone enhancement in vessels from diabetics. In arteries from pancreatectomized animals treated with insulin, PGI2 induced a biphasic (constriction and relaxation) effect of a magnitude between that of effects seen in normal controls or sham-operated and those in untreated diabetic animals. The basal radioconversion of exogenous [1-14C]AA, showed that mesenteric arteries from diabetic dogs generated more TXB2 than did vessels from intact normal control or sham-operated dogs. Moreover, in the presence of exogenous PGI2, the vascular production of TXB2 from AA in the diabetic group was significantly greater than that of preparations not exposed to PGI2. The % conversion of AA into PGI2 (assessed as 6-oxo-PGF1α) was similar in normal controls, in sham-operated and in diabetic vessels. Insulin given in vivo abolished the greater basal conversion of AA into TBX2 by mesenteric arteries from diabetic dogs and significantly attenuated the enhanced prostacyclin-evoked generation of thromboxane. The present results strongly suggest that the abnormal constricting response evoked by NaA and PGI2 in mesenteric arteries from diabetic dogs could be related to the generation of TXA2 by vessel walls. © 1984. |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: * This work was supported by grants (6638) from the Consejo Nacional de lnvestigaciones Cientificas y T6cnicas de la Repfiblica Argentina (CONICET) and by the Fundaci6n Alberto J. Roemmers, Buenos Aires, Argentina. | ||
| 593 | |a Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET), Serrano 665/69, 1414 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 6-OXO-PGF1Α |
| 690 | 1 | 0 | |a ARACHIDONIC ACID |
| 690 | 1 | 0 | |a ARTERIES |
| 690 | 1 | 0 | |a CYCLOOXYGENASE |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a LIPOXYGENASE |
| 690 | 1 | 0 | |a MESENTERIC VESSELS |
| 690 | 1 | 0 | |a PANCREATECTOMIZED DOGS |
| 690 | 1 | 0 | |a PROSTACYCLIN |
| 690 | 1 | 0 | |a PROSTAGLANDINS |
| 690 | 1 | 0 | |a THROMBOXANE |
| 690 | 1 | 0 | |a VASOCONSTRICTION |
| 690 | 1 | 0 | |a VASODILATION |
| 690 | 1 | 0 | |a 5,8,11,14 ICOSATETRAYNOIC ACID |
| 690 | 1 | 0 | |a ACETYLSALICYLIC ACID |
| 690 | 1 | 0 | |a ARACHIDONIC ACID C 14 |
| 690 | 1 | 0 | |a HALOPERIDOL |
| 690 | 1 | 0 | |a IMIDAZOLE |
| 690 | 1 | 0 | |a INDOMETACIN |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a NORDIHYDROGUAIARETIC ACID |
| 690 | 1 | 0 | |a PHENTOLAMINE |
| 690 | 1 | 0 | |a PHENTOLAMINE MESYLATE |
| 690 | 1 | 0 | |a PROSTACYCLIN |
| 690 | 1 | 0 | |a PROSTAGLANDIN SYNTHASE |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a THROMBOXANE |
| 690 | 1 | 0 | |a TRANYLCYPROMINE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a DIABETES MELLITUS |
| 690 | 1 | 0 | |a DOG |
| 690 | 1 | 0 | |a DRUG EFFICACY |
| 690 | 1 | 0 | |a ENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a MESENTERIC ARTERY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PANCREAS RESECTION |
| 690 | 1 | 0 | |a PERIPHERAL VASCULAR SYSTEM |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ARACHIDONIC ACID |
| 690 | 1 | 0 | |a ARACHIDONIC ACIDS |
| 690 | 1 | 0 | |a DIABETES MELLITUS, EXPERIMENTAL |
| 690 | 1 | 0 | |a DINOPROST |
| 690 | 1 | 0 | |a DINOPROSTONE |
| 690 | 1 | 0 | |a DOGS |
| 690 | 1 | 0 | |a EPOPROSTENOL |
| 690 | 1 | 0 | |a MESENTERIC ARTERIES |
| 690 | 1 | 0 | |a MUSCLE TONUS |
| 690 | 1 | 0 | |a MUSCLE, SMOOTH, VASCULAR |
| 690 | 1 | 0 | |a PANCREATECTOMY |
| 690 | 1 | 0 | |a PROSTAGLANDINS |
| 690 | 1 | 0 | |a PROSTAGLANDINS E |
| 690 | 1 | 0 | |a PROSTAGLANDINS F |
| 690 | 1 | 0 | |a THROMBOXANES |
| 690 | 1 | 0 | |a VASOCONSTRICTION |
| 650 | 1 | 7 | |2 spines |a DIABETES |
| 650 | 1 | 7 | |2 spines |a PANCREAS |
| 653 | 0 | 0 | |a haldol; regitine |
| 700 | 1 | |a Franchi, A.M. | |
| 700 | 1 | |a Borda, E.S. | |
| 700 | 1 | |a Castillo, E.D. | |
| 700 | 1 | |a Gimeno, M.F. | |
| 700 | 1 | |a Gimeno, A.L. | |
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