Effect of tamoxifen on the sphingolipid biosynthetic pathway in the different intraerythrocytic stages of the apicomplexa Plasmodium falciparum
Parasites of the genus Plasmodium responsible for Malaria are obligate intracellular pathogens residing in mammalian red blood cells, hepatocytes, or mosquito midgut epithelial cells. Regarding that detailed knowledge on the sphingolipid biosynthetic pathway of the apicomplexan protozoan parasites i...
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Elsevier B.V.
2018
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 15797caa a22016337a 4500 | ||
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| 003 | AR-BaUEN | ||
| 005 | 20230518204811.0 | ||
| 008 | 190410s2018 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85042561524 | |
| 024 | 7 | |2 cas |a ceramide glucosyltransferase, 37237-44-8; sphingomyelin, 85187-10-6; tamoxifen, 10540-29-1; Glycosphingolipids; inositolphosphoceramides; Phosphatidylinositols; Sphingolipids; Tamoxifen | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BBRCA | ||
| 100 | 1 | |a Piñero, T.A. | |
| 245 | 1 | 0 | |a Effect of tamoxifen on the sphingolipid biosynthetic pathway in the different intraerythrocytic stages of the apicomplexa Plasmodium falciparum |
| 260 | |b Elsevier B.V. |c 2018 | ||
| 270 | 1 | 0 | |m Couto, A.S.; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Dpto. de Química Orgánica - CONICET, Centro de Investigación en Hidratos de Carbono (CIHIDECAR), Intendente Güiraldes 2160, C1428GA, Ciudad UniversitariaArgentina; email: acouto@qo.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Parasites of the genus Plasmodium responsible for Malaria are obligate intracellular pathogens residing in mammalian red blood cells, hepatocytes, or mosquito midgut epithelial cells. Regarding that detailed knowledge on the sphingolipid biosynthetic pathway of the apicomplexan protozoan parasites is scarce, different stages of Plasmodium falciparum were treated with tamoxifen in order to evaluate the effects of this drug on the glycosphingolipid biosynthesis. Thin layer chromatography, High performance reverse phase chromatography and UV-MALDI-TOF mass spectrometry were the tools used for the analysis. In the ring forms, the increase of NBD-phosphatidyl inositol biosynthesis was notorious but differences at NBD-GlcCer levels were undetectable. In trophozoite forms, an abrupt decrease of NBD-acylated GlcDHCer and NBD-GlcDHCer in addition to an increase of NBD-PC biosynthesis was observed. On the contrary, in schizonts, tamoxifen seems not to be producing substantial changes in lipid biosynthesis. Our findings indicate that in this parasite, tamoxifen is exerting an inhibitory action on Glucosylceramidesynthase and sphingomyelin synthase levels. Moreover, regarding that Plasmodium does not biosynthesize inositolphosphoceramides, the accumulation of phosphatidylinositol should indicate an inhibitory action on glycosylinositol phospholipid synthesis. © 2018 Elsevier Inc. |l eng | |
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, ANPCyT, PICT-2013-0736 | ||
| 536 | |a Detalles de la financiación: 20020130100476BA | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, PIP-11220110100660 | ||
| 536 | |a Detalles de la financiación: PME 125 | ||
| 536 | |a Detalles de la financiación: This work was supported by: Consejo Nacional de Investigaciones Científicas y Técnicas , Grant PIP-11220110100660 , Agencia Nacional de Promoción Científica y Tecnológica grant PICT-2013-0736 and Universidad de Buenos Aires grant 20020130100476BA . AMK ( FAPESP 2014/23417-7 ). The Ultraflex II (Bruker) TOF/TOF mass spectrometer was supported by ANPCyT grant PME 125 (CEQUIBIEM). M.L., V.G.D. and A.S.C. are members of Carrera de Investigador Científico y Tecnológico of CONICET. | ||
| 593 | |a Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Dpto. de Química Orgánica - CONICET, Centro de Investigación en Hidratos de Carbono (CIHIDECAR), Intendente Güiraldes 2160, C1428GA, Ciudad Universitaria, Buenos Aires, Argentina | ||
| 593 | |a Depto. de investigación, Instituto Nacional de Parasitología “Dr Mario Fatala Chaben”, ANLIS-Malbrán, Ministerio de Salud de la Nación, Av. Paseo Colon 568, Buenos Aires, 1063, Argentina | ||
| 593 | |a Departamento de Parasitología, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil | ||
| 690 | 1 | 0 | |a GLUCOSYLCERAMIDE SYNTHASE |
| 690 | 1 | 0 | |a GLYCOSPHINGOLIPIDS |
| 690 | 1 | 0 | |a PLASMODIUM FALCIPARUM |
| 690 | 1 | 0 | |a TAMOXIFEN |
| 690 | 1 | 0 | |a CERAMIDE GLUCOSYLTRANSFERASE |
| 690 | 1 | 0 | |a GLYCOSPHINGOLIPID |
| 690 | 1 | 0 | |a PHOSPHATIDYLINOSITOL |
| 690 | 1 | 0 | |a SPHINGOLIPID |
| 690 | 1 | 0 | |a SPHINGOMYELIN |
| 690 | 1 | 0 | |a SPHINGOMYELIN SYNTHASE |
| 690 | 1 | 0 | |a TAMOXIFEN |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a GLYCOSPHINGOLIPID |
| 690 | 1 | 0 | |a INOSITOLPHOSPHOCERAMIDES |
| 690 | 1 | 0 | |a PHOSPHATIDYLINOSITOL |
| 690 | 1 | 0 | |a SPHINGOLIPID |
| 690 | 1 | 0 | |a TAMOXIFEN |
| 690 | 1 | 0 | |a APICOMPLEXA |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a ENZYME INHIBITION |
| 690 | 1 | 0 | |a HIGH PERFORMANCE LIQUID CHROMATOGRAPHY |
| 690 | 1 | 0 | |a LIFE CYCLE STAGE |
| 690 | 1 | 0 | |a LIPID STORAGE |
| 690 | 1 | 0 | |a LIPOGENESIS |
| 690 | 1 | 0 | |a MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PLASMODIUM FALCIPARUM |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a REVERSED PHASE LIQUID CHROMATOGRAPHY |
| 690 | 1 | 0 | |a SCHIZONT |
| 690 | 1 | 0 | |a SPHINGOLIPID METABOLISM |
| 690 | 1 | 0 | |a THIN LAYER CHROMATOGRAPHY |
| 690 | 1 | 0 | |a TROPHOZOITE |
| 690 | 1 | 0 | |a APICOMPLEXA |
| 690 | 1 | 0 | |a BIOSYNTHESIS |
| 690 | 1 | 0 | |a DRUG EFFECTS |
| 690 | 1 | 0 | |a ERYTHROCYTE |
| 690 | 1 | 0 | |a LIFE CYCLE STAGE |
| 690 | 1 | 0 | |a MASS SPECTROMETRY |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a PARASITOLOGY |
| 690 | 1 | 0 | |a PLASMODIUM FALCIPARUM |
| 690 | 1 | 0 | |a PROTOZOAL INFECTION |
| 690 | 1 | 0 | |a APICOMPLEXA |
| 690 | 1 | 0 | |a BIOSYNTHETIC PATHWAYS |
| 690 | 1 | 0 | |a CHROMATOGRAPHY, REVERSE-PHASE |
| 690 | 1 | 0 | |a ERYTHROCYTES |
| 690 | 1 | 0 | |a GLYCOSPHINGOLIPIDS |
| 690 | 1 | 0 | |a LIFE CYCLE STAGES |
| 690 | 1 | 0 | |a MASS SPECTROMETRY |
| 690 | 1 | 0 | |a PHOSPHATIDYLINOSITOLS |
| 690 | 1 | 0 | |a PLASMODIUM FALCIPARUM |
| 690 | 1 | 0 | |a PROTOZOAN INFECTIONS |
| 690 | 1 | 0 | |a SPHINGOLIPIDS |
| 690 | 1 | 0 | |a TAMOXIFEN |
| 700 | 1 | |a Landoni, M. | |
| 700 | 1 | |a Duschak, V.G. | |
| 700 | 1 | |a Katzin, A.M. | |
| 700 | 1 | |a Couto, A.S. | |
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