Role of TGF-β1 in the behavior disorders

Transforming growth factor 1 (TGF-β1) is an anti-inflammatory cytokine that is expressed in different regions of the mammalian brain, and at all developmental ages. This cytokine can modulate neuron differentiation and survival, and also participate in the tissular response to injury. Based on clini...

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Autor principal: Depino, A.M
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: IOS Press 2015
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100 1 |a Depino, A.M. 
245 1 0 |a Role of TGF-β1 in the behavior disorders 
260 |b IOS Press  |c 2015 
270 1 0 |m Depino, A.M.; Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA, Ciudad Universitaria, Int. Guiraldes 2160, Pabellon 2, 2do piso, Argentina; email: adepino@conicet.gov.ar 
506 |2 openaire  |e Política editorial 
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504 |a Benes, F.M., Lim, B., Matzilevich, D., Walsh, J.P., Subburaju, S., Minns, M., Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars (2007) Proc Natl Acad Sci U S A, 104 (24), pp. 10164-10169 
504 |a Vargas, D.L., Nascimbene, C., Krishnan, C., Zimmerman, A.W., Pardo, C.A., Neuroglial activation and neuroinflammation in the brain of patients with autism (2005) Ann Neurol, 57 (1), pp. 67-81 
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504 |a Yamasaki, A., Kasai, A., Toi, A., Kurita, M., Kimoto, S., Hayata-Takano, A., Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-beta (TGF-beta) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro (2015) J Neurochem, 132 (4), pp. 418-428 
520 3 |a Transforming growth factor 1 (TGF-β1) is an anti-inflammatory cytokine that is expressed in different regions of the mammalian brain, and at all developmental ages. This cytokine can modulate neuron differentiation and survival, and also participate in the tissular response to injury. Based on clinical evidence, different approaches have been used to study the role of TGF-β1 on modulating brain function and behavior. Here, we review evidence showing a role of TGF-β1 in circadian rhythms, locomotion, sociability and depression-related behaviors. For these behaviors, suprachiamatic, hippocampal and cerebellar expression of TGF-β1 have been manipulated. Further studies are required to extend these results to other brain regions and different behaviors, but so far evidence points to a role of TGF-β1 on behavior disorders such as schizophrenia, depression and autism. © 2015 - IOS Press and the authors. All rights reserved.  |l eng 
593 |a Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA, Department of Physiology, Molecular and Cellular Biology, FCEyN, University of Buenos Aires, Buenos Aires, Argentina 
690 1 0 |a AUTISM 
690 1 0 |a DEPRESSION-RELATED BEHAVIOR 
690 1 0 |a LOCOMOTION 
690 1 0 |a NEUROGENESIS 
690 1 0 |a SOCIABILITY 
690 1 0 |a TRANSFORMING GROWTH FACTOR BETA1 
690 1 0 |a AUTISM 
690 1 0 |a BRAIN FUNCTION 
690 1 0 |a CENTRAL NERVOUS SYSTEM FUNCTION 
690 1 0 |a CIRCADIAN RHYTHM 
690 1 0 |a CORPUS STRIATUM 
690 1 0 |a DEPRESSION 
690 1 0 |a HIPPOCAMPUS 
690 1 0 |a HUMAN 
690 1 0 |a LOCOMOTION 
690 1 0 |a NEUROMODULATION 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN BINDING 
690 1 0 |a PROTEIN EXPRESSION 
690 1 0 |a PROTEIN FUNCTION 
690 1 0 |a PROTEIN PHOSPHORYLATION 
690 1 0 |a REVIEW 
690 1 0 |a SCHIZOPHRENIA 
690 1 0 |a SIGNAL TRANSDUCTION 
690 1 0 |a SOCIALIZATION 
690 1 0 |a SUBSTANTIA NIGRA 
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