Acetylcholine contributes to control the physiological inflammatory response during the peri-implantation period
Background: Maternal antigen-presenting cells attracted to the pregnant uterus interact with trophoblast cells and modulate their functional profile to favour immunosuppressant responses. Non-neuronal cholinergic system is expressed in human cytotrophoblast cells and in immune cells with homeostatic...
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| Otros Autores: | , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Blackwell Publishing Ltd
2015
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| 003 | AR-BaUEN | ||
| 005 | 20230518204405.0 | ||
| 008 | 190411s2015 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84929286149 | |
| 024 | 7 | |2 cas |a acetylcholine, 51-84-3, 60-31-1, 66-23-9; atropine, 51-55-8, 55-48-1; macrophage inflammatory protein 1alpha, 155075-84-6; neostigmine, 114-80-7, 588-17-0, 59-99-4, 8048-84-8; Acetylcholine | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Paparini, D. | |
| 245 | 1 | 0 | |a Acetylcholine contributes to control the physiological inflammatory response during the peri-implantation period |
| 260 | |b Blackwell Publishing Ltd |c 2015 | ||
| 270 | 1 | 0 | |m Ramhorst, R.; Laboratory of Immunopharmacology, School of Sciences, University of Buenos Aires, Ciudad Universitaria, Pabellon 2 Piso 4., Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Background: Maternal antigen-presenting cells attracted to the pregnant uterus interact with trophoblast cells and modulate their functional profile to favour immunosuppressant responses. Non-neuronal cholinergic system is expressed in human cytotrophoblast cells and in immune cells with homeostatic regulatory functions. Aim: The aim of this work was to evaluate whether non-neuronal acetylcholine conditions maternal monocyte and DC migration and activation profiles. Methods: We used an in vitro model resembling maternal-placental interface represented by the co-culture of human trophoblast cells (Swan-71 cell line) and monocytes or DC. Results: When cytotrophoblast cells were treated with neostigmine (Neo) to concentrate endogenous acetylcholine levels, monocyte migration was increased. In parallel, high levels of IL-10 and decreased levels of TNF-α were observed upon interaction of maternal monocytes with trophoblast cells. This effect was synergized by Neo and was prevented by atropine, a muscarinic acetylcholine receptor antagonist. Similarly, trophoblast cells increased the migration of DC independently of Neo treatment; however, enhanced IL-10 and MCP-1 synthesis in trophoblast-DC co-cultures with no changes in TNF-α and IL-6 was observed. In fact, there were no changes in HLA-DR, CD86 or CD83 expression. Finally, trophoblast cells treated with Neo increased the expression of two antigen-presenting cells attracting chemokines, MCP-1, MIP-1α and RANTES through muscarinic receptors, and it was prevented by atropine. Conclusions: Our present results support a novel role of acetylcholine synthesized by trophoblast cells to modulate antigen-presenting cell migration and activation favouring an immunosuppressant profile that contributes to immune homeostasis maintenance at the maternal-foetal interface. © 2015 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd. |l eng | |
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, IQUIBICEN-CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Instituto de Medicina Experimental-IMEX-CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina | ||
| 593 | |a Servicio de Medicina Transfusional, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a DENDRITIC CELLS |
| 690 | 1 | 0 | |a MONOCYTES |
| 690 | 1 | 0 | |a NON-NEURONAL ACETYLCHOLINE |
| 690 | 1 | 0 | |a TROPHOBLAST CELLS |
| 690 | 1 | 0 | |a ACETYLCHOLINE |
| 690 | 1 | 0 | |a ATROPINE |
| 690 | 1 | 0 | |a CD83 ANTIGEN |
| 690 | 1 | 0 | |a CD86 ANTIGEN |
| 690 | 1 | 0 | |a HLA DR ANTIGEN |
| 690 | 1 | 0 | |a INTERLEUKIN 10 |
| 690 | 1 | 0 | |a INTERLEUKIN 6 |
| 690 | 1 | 0 | |a MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA |
| 690 | 1 | 0 | |a MONOCYTE CHEMOTACTIC PROTEIN 1 |
| 690 | 1 | 0 | |a MUSCARINIC RECEPTOR |
| 690 | 1 | 0 | |a NEOSTIGMINE |
| 690 | 1 | 0 | |a RANTES |
| 690 | 1 | 0 | |a TUMOR NECROSIS FACTOR ALPHA |
| 690 | 1 | 0 | |a ACETYLCHOLINE |
| 690 | 1 | 0 | |a ANTIGEN PRESENTING CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL INTERACTION |
| 690 | 1 | 0 | |a COCULTURE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOKINE PRODUCTION |
| 690 | 1 | 0 | |a CYTOTROPHOBLAST |
| 690 | 1 | 0 | |a DENDRITIC CELL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a IMMUNOMODULATION |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a INFLAMMATION |
| 690 | 1 | 0 | |a LEUKOCYTE ACTIVATION |
| 690 | 1 | 0 | |a LEUKOCYTE MIGRATION |
| 690 | 1 | 0 | |a MONOCYTE |
| 690 | 1 | 0 | |a NIDATION |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a PROTEIN SYNTHESIS |
| 690 | 1 | 0 | |a SWAN 71 CELL LINE |
| 690 | 1 | 0 | |a TROPHOBLAST |
| 690 | 1 | 0 | |a CELL SEPARATION |
| 690 | 1 | 0 | |a CYTOLOGY |
| 690 | 1 | 0 | |a IMMUNOLOGY |
| 690 | 1 | 0 | |a INFLAMMATION |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a NIDATION |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PROCEDURES |
| 690 | 1 | 0 | |a TROPHOBLAST |
| 690 | 1 | 0 | |a ACETYLCHOLINE |
| 690 | 1 | 0 | |a CELL SEPARATION |
| 690 | 1 | 0 | |a COCULTURE TECHNIQUES |
| 690 | 1 | 0 | |a EMBRYO IMPLANTATION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a INFLAMMATION |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a TROPHOBLASTS |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 700 | 1 | |a Gori, S. | |
| 700 | 1 | |a Grasso, E. | |
| 700 | 1 | |a Scordo, W. | |
| 700 | 1 | |a Calo, G. | |
| 700 | 1 | |a Pérez Leirós, C. | |
| 700 | 1 | |a Ramhorst, R. | |
| 700 | 1 | |a Salamone, G. | |
| 773 | 0 | |d Blackwell Publishing Ltd, 2015 |g v. 214 |h pp. 237-247 |k n. 2 |p Acta Physiol. |x 17481708 |w (AR-BaUEN)CENRE-3545 |t Acta Physiologica | |
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