Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions
Pathogen linear motif mimics are highly evolvable elements that facilitate rewiring of host protein interaction networks. Host linear motifs and pathogen mimics differ in sequence, leading to thermodynamic and structural differences in the resulting protein-protein interactions. Moreover, the functi...
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Elsevier Ltd
2015
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| LEADER | 22626caa a22021137a 4500 | ||
|---|---|---|---|
| 001 | PAPER-13411 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230607131859.0 | ||
| 008 | 190411s2015 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84926050157 | |
| 024 | 7 | |2 cas |a protein, 67254-75-5; Proteins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a COSBE | ||
| 100 | 1 | |a Chemes, L.B. | |
| 245 | 1 | 0 | |a Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions |
| 260 | |b Elsevier Ltd |c 2015 | ||
| 270 | 1 | 0 | |m Chemes, L.B.; Protein Structure-Function and Engineering Laboratory, Fundación Instituto Leloir and IIBBA-CONICET, Av. Patricias Argentinas 435, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Pathogen linear motif mimics are highly evolvable elements that facilitate rewiring of host protein interaction networks. Host linear motifs and pathogen mimics differ in sequence, leading to thermodynamic and structural differences in the resulting protein-protein interactions. Moreover, the functional output of a mimic depends on the motif and domain repertoire of the pathogen protein. Regulatory evolution mediated by linear motifs can be understood by measuring evolutionary rates, quantifying positive and negative selection and performing phylogenetic reconstructions of linear motif natural history. Convergent evolution of linear motif mimics is widespread among unrelated proteins from viral, prokaryotic and eukaryotic pathogens and can also take place within individual protein phylogenies. Statistics, biochemistry and laboratory models of infection link pathogen linear motifs to phenotypic traits such as tropism, virulence and oncogenicity. In vitro evolution experiments and analysis of natural sequences suggest that changes in linear motif composition underlie pathogen adaptation to a changing environment. © 2015 Elsevier Ltd. |l eng | |
| 536 | |a Detalles de la financiación: PICT 2012-2550 | ||
| 536 | |a Detalles de la financiación: PICT 2013-1985 | ||
| 536 | |a Detalles de la financiación: The authors thank L.G. Alonso, P. Beltrao, N.E. Davey, D.U. Ferreiro, A.M. Moses, M.G. Noval, N. Palopoli and R. Sieira for critical reading of the manuscript. This work was supported by ANPCyT PICT 2012-2550 grant (to I.E.S.) and by ANPCyT PICT 2013-1985 grant (to L.B.C). All authors are CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas) researchers. | ||
| 593 | |a Protein Structure-Function and Engineering Laboratory, Fundación Instituto Leloir and IIBBA-CONICET, Av. Patricias Argentinas 435, Buenos Aires, 1405, Argentina | ||
| 593 | |a Protein Physiology Laboratory, Universidad de Buenos Aires, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales and IQUIBICEN-CONICET, Buenos Aires, Argentina | ||
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