Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects
Insulin and leptin receptors are known to share signaling pathways, such as JAK2/STAT-3 (Janus kinase2/signal transduction and activator of transcription3), MAPK (Mitogen activated protein kinase), and PI3K (phosphoinositide 3-kinase). Both positive and negative cross-talk have been previously found...
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| Otros Autores: | , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Georg Thieme Verlag
2015
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 10847caa a22012017a 4500 | ||
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| 001 | PAPER-13148 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204325.0 | ||
| 008 | 190411s2015 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84955409230 | |
| 024 | 7 | |2 cas |a insulin, 9004-10-8; Insulin; Insulin Receptor Substrate Proteins; IRS1 protein, human; Leptin; Receptor, Insulin; Receptors, Leptin | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a HMMRA | ||
| 100 | 1 | |a Pérez-Pérez, A. | |
| 245 | 1 | 0 | |a Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects |
| 260 | |b Georg Thieme Verlag |c 2015 | ||
| 270 | 1 | 0 | |m Sánchez-Margalet, V.; Department of Medical Biochemistry and Molecular Biology, School of Medicine, Virgen Macarena University Hospital, Av. Dr. Fedriani 3, Spain; email: margalet@us.es |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Masuzaki, H., Ogawa, Y., Sagawa, N., Hosoda, K., Matsumoto, T., Mise, H., Nishimura, H., Nakao, K., Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans (1997) Nat Med, 3, pp. 1029-1033 | ||
| 504 | |a Senaris, R., Garcia-Caballero, T., Casabiell, X., Gallego, R., Castro, R., Considine, R.V., Dieguez, C., Casanueva, F.F., Synthesis of leptin in human placenta (1997) Endocrinology, 138, pp. 4501-4504 | ||
| 504 | |a Magarinos, M.P., Sanchez-Margalet, V., Kotler, M., Calvo, J.C., Varone, C.L., Leptin promotes cell proliferation and survival of trophoblastic cells (2007) Biol Reprod, 76, pp. 203-210 | ||
| 504 | |a Perez-Perez, A., Maymo, J., Duenas, J.L., Goberna, R., Calvo, J.C., Varone, C., Sanchez-Margalet, V., Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway (2008) Arch Biochem Biophys, 477, pp. 390-395 | ||
| 504 | |a Perez-Perez, A., Maymo, J., Gambino, Y., Duenas, J.L., Goberna, R., Varone, C., Sanchez-Margalet, V., Leptin stimulates protein synthesis-activating translation machinery in human trophoblastic cells (2009) Biol Reprod, 81, pp. 826-832 | ||
| 504 | |a Perez-Perez, A., Gambino, Y., Maymo, J., Goberna, R., Fabiani, F., Varone, C., Sanchez-Margalet, V., MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells (2010) Biochem Biophys Res Commun, 396, pp. 956-960 | ||
| 504 | |a Bajoria, R., Sooranna, S.R., Ward, B.S., Chatterjee, R., (2002) Prospective function of placental leptin at maternal-fetal interface, pp. 103-115. , 23 (ed.) | ||
| 504 | |a Perez-Perez, A., Maymo, J.L., Gambino, Y.P., Guadix, P., Duenas, J.L., Varone, C.L., Sanchez-Margalet, V., Activated translation signaling in placenta from pregnant women with gestational diabetes mellitus: Possible role of leptin (2013) Horm Metab Res, 45, pp. 436-442 | ||
| 504 | |a Sagawa, N., Yura, S., Itoh, H., Mise, H., Kakui, K., Korita, D., Takemura, M., Fujii, S., Role of leptin in pregnancy-a review (2002) Placenta, 23, pp. S80-S86 | ||
| 504 | |a Sooranna, S.R., Ward, S., Bajoria, R., Fetal leptin influences birth weight in twins with discordant growth (2001) Pediatr Res, 49, pp. 667-672 | ||
| 504 | |a Desoye, G., Hauguel-De, M.S., The human placenta in gestational diabetes mellitus. The insulin and cytokine network (2007) Diabetes Care, 30 (2), pp. S120-S126 | ||
| 504 | |a Kuruvilla, A.G., D'Souza, S.W., Glazier, J.D., Mahendran, D., Maresh, M.J., Sibley, C.P., Altered activity of the system A amino acid transporter in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women (1994) J Clin Invest, 94, pp. 689-695 | ||
| 504 | |a Fowden, A.L., Forhead, A.J., Endocrine regulation of feto-placental growth (2009) Horm Res, 72, pp. 257-265 | ||
| 504 | |a Lepercq, J., Cauzac, M., Lahlou, N., Timsit, J., Girard, J., Auwerx, J., Hauguel-De, M.S., Overexpression of placental leptin in diabetic pregnancy: A critical role for insulin (1998) Diabetes, 47, pp. 847-850 | ||
| 504 | |a Perez-Perez, A., Maymo, J., Gambino, Y., Guadix, P., Duenas, J.L., Varone, C., Sanchez-Margalet, V., Insulin Enhances Leptin Expression in Human Trophoblastic Cells (2013) Biol Reprod, 89, p. 20 | ||
| 504 | |a Barbour, L.A., McCurdy, C.E., Hernandez, T.L., Kirwan, J.P., Catalano, P.M., Friedman, J.E., Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes (2007) Diabetes Care, 30 (2), pp. S112-S119 | ||
| 504 | |a Lin, C.Y., Higginbotham, D.A., Judd, R.L., White, B.D., Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats (2002) Am J Physiol Endocrinol Metab, 282, pp. E1084-E1091 | ||
| 504 | |a Giorgetti-Peraldi, S., Peyrade, F., Baron, V., Van, O.E., Involvement of Janus kinases in the insulin signaling pathway (1995) Eur J Biochem, 234, pp. 656-660 | ||
| 504 | |a Desoye, G., Hofmann, H.H., Weiss, P.A., Insulin binding to trophoblast plasma membranes and placental glycogen content in well-controlled gestational diabetic women treated with diet or insulin, in well-controlled overt diabetic patients and in healthy control subjects (1992) Diabetologia, 35, pp. 45-55 | ||
| 504 | |a Benomar, Y., Roy, A.F., Aubourg, A., Djiane, J., Taouis, M., Cross down-regulation of leptin and insulin receptor expression and signalling in a human neuronal cell line (2005) Biochem J, 388, pp. 929-939 | ||
| 504 | |a Berti, L., Kellerer, M., Capp, E., Haring, H.U., Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for a P13-kinase mediated effect (1997) Diabetologia, 40, pp. 606-609 | ||
| 504 | |a Sweeney, G., Keen, J., Somwar, R., Konrad, D., Garg, R., Klip, A., High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting glucose transporter 4 translocation in l6 rat skeletal muscle cells (2001) Endocrinology, 142, pp. 4806-4812 | ||
| 504 | |a Szanto, I., Kahn, C.R., Selective interaction between leptin and insulin signaling pathways in a hepatic cell line (2000) Proc Natl Acad Sci USA, 97, pp. 2355-2360 | ||
| 504 | |a Baskin, D.G., Figlewicz, L.D., Seeley, R.J., Woods, S.C., Porte, D., Jr., Schwartz, M.W., Insulin and leptin: Dual adiposity signals to the brain for the regulation of food intake and body weight (1999) Brain Res, 848, pp. 114-123 | ||
| 520 | 3 | |a Insulin and leptin receptors are known to share signaling pathways, such as JAK2/STAT-3 (Janus kinase2/signal transduction and activator of transcription3), MAPK (Mitogen activated protein kinase), and PI3K (phosphoinositide 3-kinase). Both positive and negative cross-talk have been previously found in different cellular systems. Gestational diabetes (GDM) is a pathophysiological state with high circulating levels of both insulin and leptin. We have previously found that these 3 signaling pathways are activated in placenta from GDM patients to promote translation, involving the activation of leptin receptor. Now, we have tested the hypothesis that both leptin and insulin receptors might contribute to this activation in a positive way that may become negative when the system is overactivated. We studied the activation of leptin and insulin receptors in placenta from GDM and healthy pregnancies. We have also performed in vitro studies with insulin and leptin stimulation of trophoblast explants from healthy placenta. We have found that both leptin and insulin receptors are activated in placenta from GDM. In vitro stimulation of trophoblast explants with both leptin and insulin at submaximal doses (0.1 nM) potentiated the activation of signaling, whereas preincubation with maximal concentrations of insulin (10 nM) and further stimulation with leptin showed negative effect. Trophoblastic explants from GDM placenta, which presented high signaling levels, had a negative signaling effect when further incubated in vitro with leptin. In conclusion, insulin and leptin receptors have positive effects on signaling, contributing to high signaling levels in GDM placenta, but insulin and leptin have negative effects upon overstimulation. © Georg Thieme Verlag KG Stuttgart · New York. |l eng | |
| 593 | |a Department of Medical Biochemistry and Molecular Biology, School of Medicine, Virgen Macarena University Hospital, Av. Dr. Fedriani 3, Seville, 41071, Spain | ||
| 593 | |a Obstetrics and Gynecology Service, Virgen Macarena University Hospital, Seville, Spain | ||
| 593 | |a Department of Biological Chemistry, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a IVI Seville, Seville, Spain | ||
| 690 | 1 | 0 | |a GESTATIONAL DIABETES |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a INSULIN RECEPTOR |
| 690 | 1 | 0 | |a INSULIN RECEPTOR SUBSTRATE |
| 690 | 1 | 0 | |a IRS1 PROTEIN, HUMAN |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a LEPTIN RECEPTOR |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a BIOLOGICAL MODEL |
| 690 | 1 | 0 | |a CASE CONTROL STUDY |
| 690 | 1 | 0 | |a DOSE RESPONSE |
| 690 | 1 | 0 | |a DOWN REGULATION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a PHOSPHORYLATION |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PREGNANCY DIABETES MELLITUS |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a CASE-CONTROL STUDIES |
| 690 | 1 | 0 | |a DIABETES, GESTATIONAL |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a DOWN-REGULATION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a INSULIN RECEPTOR SUBSTRATE PROTEINS |
| 690 | 1 | 0 | |a LEPTIN |
| 690 | 1 | 0 | |a MODELS, BIOLOGICAL |
| 690 | 1 | 0 | |a PHOSPHORYLATION |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a RECEPTOR, INSULIN |
| 690 | 1 | 0 | |a RECEPTORS, LEPTIN |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 700 | 1 | |a Guadix, P. | |
| 700 | 1 | |a Maymó, J. | |
| 700 | 1 | |a Dueñas, J.L. | |
| 700 | 1 | |a Varone, C. | |
| 700 | 1 | |a Fernández-Sánchez, M. | |
| 700 | 1 | |a Sánchez-Margalet, V. | |
| 773 | 0 | |d Georg Thieme Verlag, 2015 |g v. 48 |h pp. 62-69 |k n. 1 |p Horm. Metab. Res. |x 00185043 |t Hormone and Metabolic Research | |
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