Wide propagation of graded signals in nonspiking neurons
Signal processing in neuritic trees is ruled by the concerted action of passive and active membrane properties that, together, determine the degree of electrical compartmentalization of these trees. We analyzed how active properties modulate spatial propagation of graded signals in a pair of nonspik...
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2013
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 12404caa a22012617a 4500 | ||
|---|---|---|---|
| 001 | PAPER-11752 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204156.0 | ||
| 008 | 190411s2013 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84873339852 | |
| 024 | 7 | |2 cas |a magnesium, 7439-95-4; Calcium, SY7Q814VUP; Calcium Channels | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JONEA | ||
| 100 | 1 | |a Yang, S.M. | |
| 245 | 1 | 0 | |a Wide propagation of graded signals in nonspiking neurons |
| 260 | |c 2013 | ||
| 270 | 1 | 0 | |m Szczupak, L.; Ciudad Universitaria, Pabellón II, piso 2, 1428 CABA, Argentina; email: szczupak@retina.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Signal processing in neuritic trees is ruled by the concerted action of passive and active membrane properties that, together, determine the degree of electrical compartmentalization of these trees. We analyzed how active properties modulate spatial propagation of graded signals in a pair of nonspiking (NS) neurons of the leech. NS neurons present a very extensive neuritic tree that mediates the interaction with all the excitatory motoneurons in leech ganglia. NS cells express voltageactivated Ca 2+ conductances (VACCs) that, under certain experimental conditions, evoke low-threshold spikes. We studied the distribution of calcium transients in NS neurons loaded with fluorescent calcium probes in response to low-threshold spikes, electrical depolarizing pulses, and synaptic inputs. The three types of stimuli evoked calcium transients of similar characteristics in the four main branches of the neuron. The magnitude of the calcium transients evoked by electrical pulses was a graded function of the change in NS membrane potential and depended on the baseline potential level. The underlying VACCs were partially inactivated at rest and strongly inactivated at - 20 mV. Stimulation of mechanosensory pressure cells evoked calcium transients in NS neurons whose amplitude was a linear function of the amplitude of the postsynaptic response. The results evidenced that VACCs aid an efficient propagation of graded signals, turning the vast neuritic tree of NS cells into an electrically compact structure. © 2013 the American Physiological Society. |l eng | |
| 593 | |a Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina | ||
| 593 | |a Instituto de Fisiología, Biología Molecular y Neurociencias, UBA-Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina | ||
| 593 | |a Grupo de Neurociencia de Sistemas, Facultad de Medicina, UBA, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CALCIUM TRANSIENTS |
| 690 | 1 | 0 | |a LOW THRESHOLD SPIKE |
| 690 | 1 | 0 | |a SIGNAL PROPAGATION |
| 690 | 1 | 0 | |a FLUORESCENT DYE |
| 690 | 1 | 0 | |a MAGNESIUM |
| 690 | 1 | 0 | |a AMPLITUDE MODULATION |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CALCIUM CONDUCTANCE |
| 690 | 1 | 0 | |a CALCIUM TRANSPORT |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DEPOLARIZATION |
| 690 | 1 | 0 | |a EVOKED RESPONSE |
| 690 | 1 | 0 | |a GANGLION |
| 690 | 1 | 0 | |a LEECH |
| 690 | 1 | 0 | |a MEMBRANE POTENTIAL |
| 690 | 1 | 0 | |a MOTONEURON |
| 690 | 1 | 0 | |a NERVE CELL |
| 690 | 1 | 0 | |a NEURITE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a NONSPIKING NEURON |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a ACTION POTENTIALS |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CALCIUM |
| 690 | 1 | 0 | |a CALCIUM CHANNELS |
| 690 | 1 | 0 | |a GANGLIA, INVERTEBRATE |
| 690 | 1 | 0 | |a LEECHES |
| 690 | 1 | 0 | |a MECHANORECEPTORS |
| 690 | 1 | 0 | |a MECHANOTRANSDUCTION, CELLULAR |
| 690 | 1 | 0 | |a MOTOR NEURONS |
| 690 | 1 | 0 | |a SYNAPTIC POTENTIALS |
| 700 | 1 | |a Vilarchao, M.E. | |
| 700 | 1 | |a Rela, L. | |
| 700 | 1 | |a Szczupak, L. | |
| 773 | 0 | |d 2013 |g v. 109 |h pp. 711-720 |k n. 3 |p J. Neurophysiol. |x 00223077 |w (AR-BaUEN)CENRE-5710 |t Journal of Neurophysiology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1152/jn.00934.2012 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00223077_v109_n3_p711_Yang |y Handle |
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