Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior
TGF-β1 is an anti-inflammatory cytokine that is augmented in the brain of autistic patients and that can affect brain development. In this work, we studied the effects of overexpressing TGF-β1 in the dentate gyrus of adult or young mice on behavior. TGF-β1 overexpression during postnatal development...
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2011
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| LEADER | 17903caa a22015977a 4500 | ||
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| 003 | AR-BaUEN | ||
| 005 | 20230518204011.0 | ||
| 008 | 190411s2011 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-80053919843 | |
| 024 | 7 | |2 cas |a RNA, Messenger; Transforming Growth Factor beta1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BBIME | ||
| 100 | 1 | |a Depino, A.M. | |
| 245 | 1 | 0 | |a Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior |
| 260 | |c 2011 | ||
| 270 | 1 | 0 | |m Depino, A.M.; Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA, Ciudad Universitaria, Int. Guiraldes S/N, Pabellon 2, 2do piso, C1428EHA Buenos Aires, Argentina; email: adepino@conicet.gov.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a TGF-β1 is an anti-inflammatory cytokine that is augmented in the brain of autistic patients and that can affect brain development. In this work, we studied the effects of overexpressing TGF-β1 in the dentate gyrus of adult or young mice on behavior. TGF-β1 overexpression during postnatal development led to a long-term decrease in social interaction and to long-term increases in self-grooming and depression-related behaviors. Our analysis shows that these behavioral changes correlate with the long-term downregulation of TGF-β1 and IL-6 expression in the dentate gyrus, as well as to decreases in the mRNA levels of the synaptic protein neuroligin 3 and in the number of Reelin-positive neurons in the dentate gyrus. In contrast, chronic expression of TGF-β1 during adulthood led to transient opposite effects on these behaviors. These results show a central role of hippocampal TGF-β1 in the programming and modulation of social interaction, repetitive behavior and depression-related behavior. Finally, our data suggest a role of hippocampal TGF-β1 and early-life neuroinflammation in the development of the behavioral alterations observed in autism spectrum disorders. © 2011 Elsevier Inc. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, UBACyT GEF2010-2012 | ||
| 536 | |a Detalles de la financiación: Fundación Florencio Fiorini, 2009 | ||
| 536 | |a Detalles de la financiación: National Council for Scientific Research | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP2010-2012 | ||
| 536 | |a Detalles de la financiación: This work was supported by a CONICET Grant PIP2010-2012 , a University of Buenos Aires Grant UBACyT GEF2010-2012 and a Florencio Fiorini Foundation Grant 2009 . A.M.D. and F.P. are members of the Research Career of the National Council of Scientific and Technological Research (CONICET), Argentina. L.L. is fellow of the CONICET. We would like to thank Maria Isabel Farias for tissue processing for histology, and Dr. Juan Belforte and Dr. Lucia Chemes for critical reading of the manuscript. Appendix A | ||
| 593 | |a Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA, C1428EHA Buenos Aires, Argentina | ||
| 593 | |a Department of Physiology, Molecular and Cellular Biology, FCEyN, University of Buenos Aires, C1428EHA Buenos Aires, Argentina | ||
| 593 | |a Leloir Institute Foundation, Institute for Biochemical Investigations, CONICET, 1405 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a AUTISM |
| 690 | 1 | 0 | |a BEHAVIOR |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a NEUROINFLAMMATION |
| 690 | 1 | 0 | |a POSTNATAL PROGRAMMING |
| 690 | 1 | 0 | |a TRANSFORMING GROWTH FACTOR-BETA 1 |
| 690 | 1 | 0 | |a INTERLEUKIN 6 |
| 690 | 1 | 0 | |a NEUROLIGIN |
| 690 | 1 | 0 | |a REELIN |
| 690 | 1 | 0 | |a TRANSFORMING GROWTH FACTOR BETA1 |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BEHAVIOR |
| 690 | 1 | 0 | |a COMPULSION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DENTATE GYRUS |
| 690 | 1 | 0 | |a DEPRESSION |
| 690 | 1 | 0 | |a GENE OVEREXPRESSION |
| 690 | 1 | 0 | |a GROOMING |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NERVE CELL |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a SOCIAL INTERACTION |
| 690 | 1 | 0 | |a ADENOVIRIDAE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BEHAVIOR, ANIMAL |
| 690 | 1 | 0 | |a DEPRESSION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GLIOSIS |
| 690 | 1 | 0 | |a GROOMING |
| 690 | 1 | 0 | |a HINDLIMB SUSPENSION |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a INTERPERSONAL RELATIONS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED C57BL |
| 690 | 1 | 0 | |a MICE, TRANSGENIC |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a REAL-TIME POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a RNA, MESSENGER |
| 690 | 1 | 0 | |a STEREOTAXIC TECHNIQUES |
| 690 | 1 | 0 | |a SWIMMING |
| 690 | 1 | 0 | |a TRANSFORMING GROWTH FACTOR BETA1 |
| 700 | 1 | |a Lucchina, L. | |
| 700 | 1 | |a Pitossi, F. | |
| 773 | 0 | |d 2011 |g v. 25 |h pp. 1582-1591 |k n. 8 |p Brain Behav. Immun. |x 08891591 |t Brain, Behavior, and Immunity | |
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