Longitudinal data analysis of polymorphisms in the k-casein and Beta - lactoglobulin genes shows differential effects along the trajectory of the lactation curve in tropical dairy goats
The k-casein [CSN-3] and Beta-lactoglobulin [BLG] genes are extensively polymorphic in ruminants Several association studies have estimated the effects of polymorphisms in these genes on milk yield, milk composition, and cheese-manufacturing properties. Usually, these results are based on production...
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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| Acceso en línea: | http://ri.agro.uba.ar/files/intranet/articulo/2016cardona.pdf LINK AL EDITOR |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
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| 024 | |a 10.3168/jds.2016-10954 | ||
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| 245 | 1 | 0 | |a Longitudinal data analysis of polymorphisms in the k-casein and Beta - lactoglobulin genes shows differential effects along the trajectory of the lactation curve in tropical dairy goats |
| 520 | |a The k-casein [CSN-3] and Beta-lactoglobulin [BLG] genes are extensively polymorphic in ruminants Several association studies have estimated the effects of polymorphisms in these genes on milk yield, milk composition, and cheese-manufacturing properties. Usually, these results are based on production integrated over the lactation curve or on cross-sectional studies at specific days in milk [DIM]. However, as differential expression of milk protein genes occurs over lactation, the effect of the polymorphisms may change over time. In this study, we fitted a mixed-effects regression model to test-day records of milk yield and milk quality traits [fat, protein, and total solids yields] from Colombian tropical dairy goats. We used the well-characterized A/B polymorphisms in the CSN-3 and BLG genes. We argued that this approach provided more efficient estimators than cross-sectional designs, given the same number and pattern of observations, and allowed exclusion of between-subject variation from model error. The BLG genotype AA showed a greater performance than the BB genotype for all traits along the whole lactation curve, whereas the heterozygote showed an intermediate performance. We observed no such constant pattern for the CSN-3 gene between the AA homozygote and the heterozygote [the BB genotype was absent from the sample]. The differences among the genotypic effects of the BLG and the CSN-3 polymorphisms were statistically significant during peak and mid lactation [around 40.160 DIM] for the BLG gene and only for mid lactation [80.145 DIM] for the CSN-3 gene. We also estimated the additive and dominant effects of the BLG locus. The locus showed a statistically significant additive behavior along the whole lactation trajectory for all quality traits, whereas for milk yield the effect was not significant at later stages. In turn, we detected a statistically significant dominance effect only for fat yield in the early and peak stages of lactation [at about 1.45 DIM]. The longitudinal analysis of test-day records allowed us to estimate the differential effects of polymorphisms along the lactation curve, pointing toward stages that could be affected by the gene. | ||
| 650 | |2 Agrovoc |9 26 | ||
| 653 | 0 | |a LONGITUDINAL DATA | |
| 653 | 0 | |a DAIRY GOATS | |
| 653 | 0 | |a ADDITIVE | |
| 653 | 0 | |a DOMINANCE | |
| 653 | 0 | |a BETA LACTOGLOBULIN | |
| 653 | 0 | |a K CASEIN | |
| 700 | 1 | |a Calvo Cardona, Samir Julián |9 70283 | |
| 700 | 1 | |a Cardona Cadavid, Henry |9 70284 | |
| 700 | 1 | |a Corrales Alvarez, Juan David |9 38013 | |
| 700 | 1 | |9 13019 |a Munilla Leguizamón, Sebastián | |
| 700 | 1 | |9 12817 |a Cantet, Rodolfo Juan Carlos | |
| 700 | 1 | |a Rogberg Muñoz, Andrés |9 37756 | |
| 773 | |t Journal of Dairy Science |g vol. 99, no. 9 (2016), p.7299-7307, tbls., grafs. | ||
| 856 | |u http://ri.agro.uba.ar/files/intranet/articulo/2016cardona.pdf |i En reservorio |q application/pdf |f 2016cardona |x MIGRADOS2018 | ||
| 856 | |u https://www.elsevier.com/ |x MIGRADOS2018 |z LINK AL EDITOR | ||
| 942 | 0 | 0 | |c ARTICULO |
| 942 | 0 | 0 | |c ENLINEA |
| 976 | |a AAG | ||