Modelling inter - human transmission dynamics of Chagas disease analysis and application
Transmission of Trypanosoma cruzi, the causal agent of Chagas disease, has expanded from rural endemic to urban areas due to migration. This so-called urban Chagas is an emerging health problem in American, European, Australian and Japanese cities. We present a mathematical model to analyse the dyna...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , |
| Formato: | Artículo |
| Lenguaje: | Español |
| Materias: | |
| Acceso en línea: | http://ri.agro.uba.ar/files/intranet/articulo/2014fabrizio1.pdf LINK AL EDITOR |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 03150cab a22005657a 4500 | ||
|---|---|---|---|
| 001 | AR-BaUFA000728 | ||
| 003 | AR-BaUFA | ||
| 005 | 20221024142748.0 | ||
| 008 | 181208t2014 |||||o|||||00||||spa d | ||
| 999 | |c 47124 |d 47124 | ||
| 999 | |d 47124 | ||
| 022 | |a 0031-1820 | ||
| 024 | |a 10.1017/S0031182013002199 | ||
| 040 | |a AR-BaUFA | ||
| 100 | 1 | |9 29336 |a Fabrizio, María del Carmen | |
| 245 | 0 | 0 | |a Modelling inter - human transmission dynamics of Chagas disease |b analysis and application |
| 520 | |a Transmission of Trypanosoma cruzi, the causal agent of Chagas disease, has expanded from rural endemic to urban areas due to migration. This so-called urban Chagas is an emerging health problem in American, European, Australian and Japanese cities. We present a mathematical model to analyse the dynamics of urban Chagas to better understand its epidemiology. The model considers the three clinical stages of the disease and the main routes of inter-human transmission. To overcome the complexities of the infection dynamics, the next-generation matrix method was developed. We deduced expressions which allowed estimating the number of new infections generated by an infected individual through each transmission route at each disease stage, the basic reproduction number and the number of individuals at each disease stage at the outbreak of the infection. The analysis was applied to Buenos Aires city [Argentina]. We estimated that 94 percent of the new infections are generated by individuals in the chronic indeterminate stage. When migration was not considered, the infection disappeared slowly and R 0=0·079, whereas when migration was considered, the number of individuals in each stage of the infection tended to stabilize. The expressions can be used to estimate different numbers of infected individuals in any place where only inter-human transmission is possible. | ||
| 650 | |2 Agrovoc |9 26 | ||
| 653 | 0 | |a ARGENTINA | |
| 653 | 0 | |a BASIC REPRODUCTION NUMBER | |
| 653 | 0 | |a BIRTH RATE | |
| 653 | 0 | |a BLOOD TRANSFUSION | |
| 653 | 0 | |a CHAGAS DISEASE | |
| 653 | 0 | |a CHRONIC DISEASE | |
| 653 | 0 | |a CITY | |
| 653 | 0 | |a CONGENITAL DISORDER | |
| 653 | 0 | |a CONGENITAL INFECTION | |
| 653 | 0 | |a DISEASE TRANSMISSION | |
| 653 | 0 | |a DYNAMICS | |
| 653 | 0 | |a EPIDEMIC | |
| 653 | 0 | |a HUMAN | |
| 653 | 0 | |a MAJOR CLINICAL STUDY | |
| 653 | 0 | |a MATHEMATICAL MODEL | |
| 653 | 0 | |a MIGRATION | |
| 653 | 0 | |a MORTALITY | |
| 653 | 0 | |a NEXT-GENERATION MATRIX | |
| 653 | 0 | |a PARASITE TRANSMISSION | |
| 653 | 0 | |a SENSITIVITY ANALYSIS | |
| 653 | 0 | |a SUSCEPTIBLE POPULATION | |
| 653 | 0 | |a TRYPANOSOMA CRUZI | |
| 653 | 0 | |a URBAN AREA | |
| 653 | 0 | |a URBAN CHAGAS | |
| 700 | 1 | |a Schweigmann, Nicolas J. |9 67741 | |
| 700 | 1 | |9 6346 |a Bartoloni, Norberto José | |
| 773 | |t Parasitology |g vol.141, no.6 (2014), p.837-848 | ||
| 856 | |u http://ri.agro.uba.ar/files/intranet/articulo/2014fabrizio1.pdf |i En reservorio |q application/pdf |f 2014fabrizio1 |x MIGRADOS2018 | ||
| 856 | |u http://journals.cambridge.org/action/login?sessionId=40C26FE62002D4C8BDA574D7071D671C.journals |x MIGRADOS2018 |z LINK AL EDITOR | ||
| 942 | 0 | 0 | |c ARTICULO |
| 942 | 0 | 0 | |c ENLINEA |
| 976 | |a AAG | ||