Amino Acid Sequence Binding energy Biochemical interactions Biosynthetic pathway Crystal structure Drug Design Enzyme Inhibitors Enzymes Free energy Hydrazones Indans Life cycle Models, Molecular Molecular Docking Simulation Molecular Dynamics Simulation Molecular dynamics Molecular simulations Pharmacophore modeling Protein Conformation Protozoan Trypanosoma Squalene Monooxygenase Structural similarity Superposition analysis Theoretical calculations Thermodynamics Trypanosoma cruzi amino acid sequence antagonists and inhibitors chemistry drug design