Nucleic Acid Conformation article nonhuman priority journal Dengue Virus Dengue virus Flavivirus Microscopy, Atomic Force RNA replication RNA, Viral Virus Replication atomic force microscopy virus RNA virus genome Animals Base Sequence Binding Sites Molecular Sequence Data AFM Cell Line Cricetinae Genome, Viral Models, Molecular Mutagenesis, Site-Directed NS5 protein, flavivirus RNA RNA Replicase RNA binding RNA cyclization RNA directed RNA polymerase