cytokine gene targeting gene therapy priority journal Arthritis, Rheumatoid Gene Therapy Genetic Vectors Humans T lymphocyte antirheumatic agent antisense oligonucleotide autoimmune disease beta interferon cell type clinical trial complement system conference paper cytokine receptor gene transfer human immunoglobulin enhancer binding protein immunoglobulin fragment immunotherapy interleukin 1 interleukin 1 receptor blocking agent interleukin 10 major clinical study mediator meta analysis plasmid DNA