APOPTOSIS COACTIVADORES DE RECEPTORES NUCLEARES NF-KB NUCLEAR RECEPTOR COACTIVATORS Cell Nucleus Cytoplasm Enzyme Activation Humans I kappa B MAPK NCOA2 protein, human NF-kappa B NF-κB Nuclear Receptor Coactivator 2 Nuclear receptor coactivators Phosphorylation TIF2 Trans-Activation (Genetics) Transcription Factors article cell nucleus cell protein cytoplasm dose response drug antagonism enzyme activation enzyme activity gene overexpression human human cell